Mechanisms and Applications of RNA Interference

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Liu, H., Zask, A., Forouhar, F., Iketani, S., Williams, A., Vaz, D. R., Habashi, D., Choi, K., Resnick, S. J., Hong, S. J., Lovett, D. H., Bai, T., Chavez, A., Ho, D. D., & Stockwell, B. R. (2025). Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screening. Nature Communications, 16(1). https://doi.org/10.1038/s41467-024-55421-5
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Falnikar, A., Quintremil, S., Zhao, H.-J., Cheng, H.-Y., Helmer, P., Tsai, J.-W., & Vallee, R. B. (2024). The nucleoporin Nup153 is the anchor for Kif1a during basal nuclear migration in brain progenitor cells. Cell Reports, 43(12), 115008. https://doi.org/10.1016/j.celrep.2024.115008
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Clark, V. C., Strange, C., Strnad, P., Sanchez, A. J., Kwo, P., Pereira, V. M., van Hoek, B., Barjaktarevic, I., Corsico, A. G., Pons, M., Goldklang, M., Gray, M., Kuhn, B., Vargas, H. E., Vierling, J. M., Vuppalanchi, R., Brantly, M., Kappe, N., Chang, T., … Loomba, R. (2024). Fazirsiran for Adults With Alpha-1 Antitrypsin Deficiency Liver Disease: A Phase 2 Placebo Controlled Trial (SEQUOIA). Gastroenterology. https://doi.org/10.1053/j.gastro.2024.06.028
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Sah, B., Singh, J., Shen, Y., Goldfarb, N., Samie, F. H., Geskin, L. J., & Liu, L. (2024). Loss of CELF2 promotes skin tumorigenesis and increases drug resistance. International Journal of Dermatology. Portico. https://doi.org/10.1111/ijd.17295
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Cheng, K., Seita, Y., Whelan, E. C., Yokomizo, R., Hwang, Y. S., Rotolo, A., Krantz, I. D., Ginsberg, J. P., Kolon, T. F., Lal, P., Luo, X., Pierorazio, P. M., Linn, R. L., Ryeom, S., & Sasaki, K. (2024). Defining the cellular origin of seminoma by transcriptional and epigenetic mapping to the normal human germline. Cell Reports, 43(6), 114323. https://doi.org/10.1016/j.celrep.2024.114323
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Costa, B. L. da, Quinn, P. M. J., Wu, W.-H., Liu, S., Nolan, N. D., Demirkol, A., Tsai, Y.-T., Caruso, S. M., Cabral, T., Wang, N.-K., & Tsang, S. H. (2024). Targeting miR-181a/b in retinitis pigmentosa: implications for disease progression and therapy. Cell & Bioscience, 14(1). https://doi.org/10.1186/s13578-024-01243-3
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Gordillo-Sampedro, S., Antounians, L., Wei, W., Mufteev, M., Lendemeijer, B., Kushner, S. A., de Vrij, F. M. S., Zani, A., & Ellis, J. (2024). iPSC-derived healthy human astrocytes selectively load miRNAs targeting neuronal genes into extracellular vesicles. Molecular and Cellular Neuroscience, 129, 103933. https://doi.org/10.1016/j.mcn.2024.103933
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Dubey, S., Chen, Z., Jiang, Y. J., Talis, A., Molotkov, A., Ali, A., Mintz, A., & Momen-Heravi, F. (2024). Small extracellular vesicles (sEVs)-based gene delivery platform for cell-specific CRISPR/Cas9 genome editing. Theranostics, 14(7), 2777–2793. https://doi.org/10.7150/thno.92133
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Chen, Y., Zhang, K., Zhang, R., Wang, Z., Yang, L., Zhao, T., Zhang, S., Lin, Y., Zhao, H., Liu, Y., Wei, Y., Zhou, Y., Zhang, J., Ye, X., Zhao, J., Li, X., Que, J., Shi, S., & Liu, K. (2023). Targeting the SOX2/CDP protein complex with a peptide suppresses the malignant progression of esophageal squamous cell carcinoma. Cell Death Discovery, 9(1). https://doi.org/10.1038/s41420-023-01693-7
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Shi, P., Murphy, M. R., Aparicio, A. O., Kesner, J. S., Fang, Z., Chen, Z., Trehan, A., Guo, Y., & Wu, X. (2023). Collateral activity of the CRISPR/RfxCas13d system in human cells. Communications Biology, 6(1). https://doi.org/10.1038/s42003-023-04708-2
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Xiao, Y., Fang, H., Zhu, Y., Zhou, J., Dai, Z., Wang, H., Xia, Z., Tu, Z., & Leong, K. W. (2023). Multifunctional Cationic Hyperbranched Polyaminoglycosides that Target Multiple Mediators for Severe Abdominal Trauma Management. Advanced Science, 11(1). Portico. https://doi.org/10.1002/advs.202305273
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Li, F., Chen, D., Sun, Q., Wu, J., Gan, Y., Leong, K. W., & Liang, X. (2023). MDM2‐Targeting Reassembly Peptide (TRAP) Nanoparticles for p53‐Based Cancer Therapy. Advanced Materials, 35(45). Portico. https://doi.org/10.1002/adma.202305164
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Baranello, G., Chiriboga, C., Servais, L., Darras, B., Day, J., Deconinck, N., Farrar, M., Finkel, R., Bertini, E., Kirschner, J., Rasson, M., Mazurkiewicz-Bełdzińska, M., Vlodavets, D., Bader-Weder, S., Gorni, K., Jaber, B., Yeung, W., Papp, G., Scalco, R., & Mercuri, E. (2023). P230 Safety update: Risdiplam clinical trial program for spinal muscular atrophy (SMA). Neuromuscular Disorders, 33, S92–S93. https://doi.org/10.1016/j.nmd.2023.07.112
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Li, T., Akinade, T., Zhou, J., Wang, H., Tong, Q., He, S., Rinebold, E., Valencia Salazar, L. E., Bhansali, D., Zhong, Y., Ruan, J., Du, J., Dalerba, P., & Leong, K. W. (2022). Therapeutic Nanocarriers Inhibit Chemotherapy‐Induced Breast Cancer Metastasis. Advanced Science, 9(33). Portico. https://doi.org/10.1002/advs.202203949
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Liu, Y., Wu, Z., Zhou, J., Ramadurai, D. K. A., Mortenson, K. L., Aguilera-Jimenez, E., Yan, Y., Yang, X., Taylor, A. M., Varley, K. E., Gertz, J., Choi, P. S., Cherniack, A. D., Chen, X., Bass, A. J., Bailey, S. D., & Zhang, X. (2021). A predominant enhancer co-amplified with the SOX2 oncogene is necessary and sufficient for its expression in squamous cancer. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-27055-4
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