Pancreatic Islet Dysfunction and Regeneration

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Craig-Schapiro, R., Li, G., Chen, K., Gomez-Salinero, J. M., Nachman, R., Kopacz, A., Schreiner, R., Chen, X., Zhou, Q., Rafii, S., & Redmond, D. (2025). Single-cell atlas of human pancreatic islet and acinar endothelial cells in health and diabetes. Nature Communications, 16(1). https://doi.org/10.1038/s41467-024-55415-3
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Agarwal, H., Wang, Y., Tinsley, B., Wang, X., & Ozcan, L. (2025). RAP1A suppresses hepatic steatosis by regulating amino acid-mediated mTORC1 activation. JHEP Reports, 7(4), 101303. https://doi.org/10.1016/j.jhepr.2024.101303
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Yang, L., Han, Y., Zhang, T., Dong, X., Ge, J., Roy, A., Zhu, J., Lu, T., Jeya Vandana, J., de Silva, N., Robertson, C. C., Xiang, J. Z., Pan, C., Sun, Y., Que, J., Evans, T., Liu, C., Wang, W., Naji, A., … Chen, S. (2024). Human vascularized macrophage-islet organoids to model immune-mediated pancreatic β cell pyroptosis upon viral infection. Cell Stem Cell. https://doi.org/10.1016/j.stem.2024.08.007
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Calì, F., Ladanyi, A., Pinsino, A., Antler, K., Murphy, J., Mondellini, G. M., Kaku, Y., Sayer, G., Uriel, N., Takeda, K., Colombo, P. C., Jennings, D., & Yuzefpolskaya, M. (2024). Sodium Glucose Co-Transporter 2 Inhibitor Use in HeartMate 3 Patients. The Journal of Heart and Lung Transplantation, 43(4), S647. https://doi.org/10.1016/j.healun.2024.02.1028
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Kwak, S. H., Srinivasan, S., Chen, L., Todd, J., Mercader, J. M., Jensen, E. T., Divers, J., Mottl, A. K., Pihoker, C., Gandica, R. G., Laffel, L. M., Isganaitis, E., Haymond, M. W., Levitsky, L. L., Pollin, T. I., Florez, J. C., & Flannick, J. (2024). Genetic architecture and biology of youth-onset type 2 diabetes. Nature Metabolism, 6(2), 226–237. https://doi.org/10.1038/s42255-023-00970-0
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Columbia Affiliation
Rasouli, N., Younes, N., Ghosh, A., Albu, J., Cohen, R. M., DeFronzo, R. A., Diaz, E., Sayyed Kassem, L., Luchsinger, J. A., McGill, J. B., Sivitz, W. I., Tamborlane, W. V., Utzschneider, K. M., Kahn, S. E., Crandall, J. P., McKee, M. D., Behringer-Massera, S., Brown-Friday, J., … Xhori, E. (2024). Longitudinal Effects of Glucose-Lowering Medications on β-Cell Responses and Insulin Sensitivity in Type 2 Diabetes: The GRADE Randomized Clinical Trial. Diabetes Care, 47(4), 580–588. https://doi.org/10.2337/dc23-1070
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Park, J., Hall, C., Hubbard, B., LaMoia, T., Gaspar, R., Nasiri, A., Li, F., Zhang, H., Kim, J., Haeusler, R. A., Accili, D., Shulman, G. I., Yu, H., & Choi, E. (2023). MAD2-Dependent Insulin Receptor Endocytosis Regulates Metabolic Homeostasis. Diabetes, 72(12), 1781–1794. https://doi.org/10.2337/db23-0314
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Senatus, L., Egaña-Gorroño, L., López-Díez, R., Bergaya, S., Aranda, J. F., Amengual, J., Arivazhagan, L., Manigrasso, M. B., Yepuri, G., Nimma, R., Mangar, K. N., Bernadin, R., Zhou, B., Gugger, P. F., Li, H., Friedman, R. A., Theise, N. D., Shekhtman, A., Fisher, E. A., … Schmidt, A. M. (2023). DIAPH1 mediates progression of atherosclerosis and regulates hepatic lipid metabolism in mice. Communications Biology, 6(1). https://doi.org/10.1038/s42003-023-04643-2
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Stamatiades, G. A., D’Silva, P., Elahee, M., Viana, G. M., Sideri-Gugger, A., & Majumdar, S. K. (2023). Diabetic Ketoacidosis Associated with Sodium-Glucose Cotransporter 2 Inhibitors: Clinical and Biochemical Characteristics of 29 Cases. International Journal of Endocrinology, 2023, 1–7. https://doi.org/10.1155/2023/6615624
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Aiello, J. J., Bogart, M. C., Chan, W.-T., Holoman, N. C., Trobenter, T. D., Relf, C. E., Kleinman, D. M., De Vivo, D. C., & Samuels, I. S. (2023). Systemic Reduction of Glut1 Normalizes Retinal Dysfunction, Inflammation, and Oxidative Stress in the Retina of Spontaneous Type 2 Diabetic Mice. The American Journal of Pathology, 193(7), 927–938. https://doi.org/10.1016/j.ajpath.2023.04.003
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Habes, M., Jacobson, A. M., Braffett, B. H., Rashid, T., Ryan, C. M., Shou, H., Cui, Y., Davatzikos, C., Luchsinger, J. A., Biessels, G. J., Bebu, I., Gubitosi-Klug, R. A., Bryan, R. N., & Nasrallah, I. M. (2023). Patterns of Regional Brain Atrophy and Brain Aging in Middle- and Older-Aged Adults With Type 1 Diabetes. JAMA Network Open, 6(6), e2316182. https://doi.org/10.1001/jamanetworkopen.2023.16182
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Weiner, A., Zhang, M., Ren, S., Tchang, B., Gandica, R., & Murillo, J. (2023). Progression from prediabetes to type 2 diabetes mellitus in adolescents: a real world experience. Frontiers in Clinical Diabetes and Healthcare, 4. https://doi.org/10.3389/fcdhc.2023.1181729
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Tayebi, N., Leon‐Ricardo, B., McCall, K., Mehinovic, E., Engelstad, K., Huynh, V., Turner, T. N., Weisenberg, J., Thio, L. L., Hruz, P., Williams, R. S. B., De Vivo, D. C., Petit, V., Haller, G., & Gurnett, C. A. (2023). Quantitative determination of SLC2A1 variant functional effects in GLUT1 deficiency syndrome. Annals of Clinical and Translational Neurology, 10(5), 787–801. Portico. https://doi.org/10.1002/acn3.51767
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Du, W., Wang, J., Kuo, T., Wang, L., McKimpson, W. M., Son, J., Watanabe, H., Kitamoto, T., Lee, Y., Creusot, R. J., Ratner, L. E., McCune, K., Chen, Y.-W., Grubbs, B. H., Thornton, M. E., Fan, J., Sultana, N., Diaz, B. S., Balasubramanian, I., … Accili, D. (2022). Pharmacological conversion of gut epithelial cells into insulin-producing cells lowers glycemia in diabetic animals. Journal of Clinical Investigation, 132(24). https://doi.org/10.1172/jci162720
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Chu, C. M. J., Modi, H., Ellis, C., Krentz, N. A. J., Skovsø, S., Zhao, Y. B., Cen, H., Noursadeghi, N., Panzhinskiy, E., Hu, X., Dionne, D. A., Xia, Y. H., Xuan, S., Huising, M. O., Kieffer, T. J., Lynn, F. C., & Johnson, J. D. (2022). Dynamic Ins2 Gene Activity Defines β-Cell Maturity States. Diabetes, 71(12), 2612–2631. https://doi.org/10.2337/db21-1065
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González, B. J., Zhao, H., Niu, J., Williams, D. J., Lee, J., Goulbourne, C. N., Xing, Y., Wang, Y., Oberholzer, J., Blumenkrantz, M. H., Chen, X., LeDuc, C. A., Chung, W. K., Colecraft, H. M., Gromada, J., Shen, Y., Goland, R. S., Leibel, R. L., & Egli, D. (2022). Reduced calcium levels and accumulation of abnormal insulin granules in stem cell models of HNF1A deficiency. Communications Biology, 5(1). https://doi.org/10.1038/s42003-022-03696-z
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Yoon, N. A., Jin, S., Kim, J. D., Liu, Z. W., Sun, Q., Cardone, R., Kibbey, R., & Diano, S. (2022). UCP2-dependent redox sensing in POMC neurons regulates feeding. Cell Reports, 41(13), 111894. https://doi.org/10.1016/j.celrep.2022.111894
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Huang, P.-P., Zhu, W.-Q., Xiao, J.-M., Zhang, Y.-Q., Li, R., Yang, Y., Shen, L., Luo, F., Dai, W., Lian, P.-A., Tang, Y.-X., Ran, J.-L., & Huang, X.-S. (2022). Alterations in sorting and secretion of hepatic apoA5 induce hypertriglyceridemia due to short-term use of olanzapine. Frontiers in Pharmacology, 13. https://doi.org/10.3389/fphar.2022.935362
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Gong, Y.-Y., Shao, H., Li, Y., Brafford, P., Stine, Z. E., Sun, J., Felsher, D. W., Orange, J. S., Albelda, S. M., & Dang, C. V. (2022). Na+/H+-exchanger 1 Enhances Antitumor Activity of Engineered NK-92 Natural Killer Cells. Cancer Research Communications, 2(8), 842–856. https://doi.org/10.1158/2767-9764.crc-22-0270
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Caplan, L. R., Vavinskaya, V., Gelikman, D. G., Jyotsana, N., Trinh, V. Q., Olive, K. P., Tan, M. C. B., & DelGiorno, K. E. (2022). Enteroendocrine Cell Formation Is an Early Event in Pancreatic Tumorigenesis. Frontiers in Physiology, 13. https://doi.org/10.3389/fphys.2022.865452
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Marks, B. E., Williams, K. M., Sherwood, J. S., & Putman, M. S. (2022). Practical aspects of diabetes technology use: Continuous glucose monitors, insulin pumps, and automated insulin delivery systems. Journal of Clinical & Translational Endocrinology, 27, 100282. https://doi.org/10.1016/j.jcte.2021.100282
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Nakkina, S., Gitto, S., Pandey, V., Parikh, J., Geerts, D., Maurer, H., Olive, K., Phanstiel, O., & Altomare, D. (2021). Differential Expression of Polyamine Pathways in Human Pancreatic Tumor Progression and Effects of Polyamine Blockade on Tumor Microenvironment. Cancers, 13(24), 6391. https://doi.org/10.3390/cancers13246391
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Son, J., Ding, H., Farb, T. B., Efanov, A. M., Sun, J., Gore, J. L., Syed, S. K., Lei, Z., Wang, Q., Accili, D., & Califano, A. (2021). BACH2 inhibition reverses β cell failure in type 2 diabetes models. Journal of Clinical Investigation, 131(24). https://doi.org/10.1172/jci153876
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