Molecular Mechanisms of Ion Channels Regulation

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Lado, W., Wu, X., Choi, S., Dong, Y., Yang, G., Arancio, O., Tempia, F., Miniaci, M. C., Sulzer, D., Mosharov, E., & Tang, G. (2025). Synaptic plasticity deficits in a mouse model of Timothy syndrome: LTP saturation and its pharmacological rescue by nifedipine. Biomedicine & Pharmacotherapy, 184, 117896. https://doi.org/10.1016/j.biopha.2025.117896
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del Rivero Morfin, P. J., Chavez, D. S., Jayaraman, S., Yang, L., Geisler, S. M., Kochiss, A. L., Tuluc, P., Colecraft, H. M., Marx, S. O., Liu, X. S., Rajadhyaksha, A. M., & Ben-Johny, M. (2024). A genetically encoded actuator boosts L-type calcium channel function in diverse physiological settings. Science Advances, 10(44). https://doi.org/10.1126/sciadv.adq3374
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Bruce, S. L., Cuomo, M., Yarmohammadi, H., Wan, E. Y., Saluja, D., Sciacca, R., Garan, H., Griffin, J. M., Maurer, M. S., & Biviano, A. B. (2024). Monitoring for arrhythmia in transthyretin cardiac amyloidosis with noninvasive ambulatory patch devices. Heart Rhythm O2. https://doi.org/10.1016/j.hroo.2024.07.013
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Gangwar, S. P., Yelshanskaya, M. V., Nadezhdin, K. D., Yen, L. Y., Newton, T. P., Aktolun, M., Kurnikova, M. G., & Sobolevsky, A. I. (2024). Kainate receptor channel opening and gating mechanism. Nature, 630(8017), 762–768. https://doi.org/10.1038/s41586-024-07475-0
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Wang, L., Hoang, A., Gil-Iturbe, E., Laganowsky, A., Quick, M., & Zhou, M. (2024). Mechanism of anion exchange and small-molecule inhibition of pendrin. Nature Communications, 15(1). https://doi.org/10.1038/s41467-023-44612-1
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Tong, C., Moayedi, Y., & Lumpkin, E. A. (2024). Merkel cells and keratinocytes in oral mucosa are activated by mechanical stimulation. Physiological Reports, 12(2). Portico. https://doi.org/10.14814/phy2.15826
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Chen, C., Sun, L., Adler, A., Zhou, H., Zhang, L., Zhang, L., Deng, J., Bai, Y., Zhang, J., Yang, G., Gan, W.-B., & Tang, P. (2023). Synchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic pain. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-36093-z
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Citterio, C. E., Kim, K., Rajesh, B., Pena, K., Clarke, O. B., & Arvan, P. (2023). Structural features of thyroglobulin linked to protein trafficking. Protein Science, 32(11). Portico. https://doi.org/10.1002/pro.4784
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Allen, N. M., O’Rahelly, M., Eymard, B., Chouchane, M., Hahn, A., Kearns, G., Kim, D.-S., Byun, S. Y., Nguyen, C.-T. E., Schara-Schmidt, U., Kölbel, H., Marina, A. D., Schneider-Gold, C., Roefke, K., Thieme, A., Van den Bergh, P., Avalos, G., Álvarez-Velasco, R., Natera-de Benito, D., … Jungbluth, H. (2023). The emerging spectrum of fetal acetylcholine receptor antibody-related disorders (FARAD). Brain, 146(10), 4233–4246. https://doi.org/10.1093/brain/awad153
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Hirsch, Y., Chung, W. K., Novoselov, S., Weimer, L. H., Rossor, A., LeDuc, C. A., McPartland, A. J., Cabrera, E., Ekstein, J., Scher, S., Nelson, R. F., Schiavo, G., Henderson, L. B., & Booth, K. T. A. (2023). Biallelic Loss-of-Function Variants in BICD1 Are Associated with Peripheral Neuropathy and Hearing Loss. International Journal of Molecular Sciences, 24(10), 8897. https://doi.org/10.3390/ijms24108897
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Jayaraman, S., Alacay, T.-L., Rivero Morfin, P. J. del, Lauris Kochiss, A., & Ben-Johny, M. (2023). FacePalm: Probing dynamic S-palmitoylation of CaV channel complexes using engineered depalmitoylases. Biophysical Journal, 122(3), 310a. https://doi.org/10.1016/j.bpj.2022.11.1744
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Gangwar, S. P., Yen, L. Y., Yelshanskaya, M. V., & Sobolevsky, A. I. (2023). Positive and negative allosteric modulation of GluK2 kainate receptors by BPAM344 and antiepileptic perampanel. Cell Reports, 42(2), 112124. https://doi.org/10.1016/j.celrep.2023.112124
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Hussey, J. W., DeMarco, E., DiSilvestre, D., Jensen, H. H., Ben-Johny, M., Nyegaard, M., Overgaard, M. T., & Dick, I. E. (2023). Disease-associated calmodulin variants impair regulation of neuronal voltage-gated calcium channels. Biophysical Journal, 122(3), 105a. https://doi.org/10.1016/j.bpj.2022.11.754
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Morgenstern, T. J., Nirwan, N., Hernández-Ochoa, E. O., Bibollet, H., Choudhury, P., Laloudakis, Y. D., Ben Johny, M., Bannister, R. A., Schneider, M. F., Minor, D. L., & Colecraft, H. M. (2022). Selective posttranslational inhibition of CaVβ1-associated voltage-dependent calcium channels with a functionalized nanobody. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-35025-7
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Miceli, F., Millevert, C., Soldovieri, M. V., Mosca, I., Ambrosino, P., Carotenuto, L., Schrader, D., Lee, H. K., Riviello, J., Hong, W., Risen, S., Emrick, L., Amin, H., Ville, D., Edery, P., de Bellescize, J., Michaud, V., Van-Gils, J., Goizet, C., … Weckhuysen, S. (2022). KCNQ2 R144 variants cause neurodevelopmental disability with language impairment and autistic features without neonatal seizures through a gain-of-function mechanism. EBioMedicine, 81, 104130. https://doi.org/10.1016/j.ebiom.2022.104130
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Sun, L., Tong, C.-K., Morgenstern, T. J., Zhou, H., Yang, G., & Colecraft, H. M. (2022). Targeted ubiquitination of sensory neuron calcium channels reduces the development of neuropathic pain. Proceedings of the National Academy of Sciences, 119(20). https://doi.org/10.1073/pnas.2118129119
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Blomquist, V. G., Niu, J., Colecraft, H. M., & Ahern, C. A. (2022). Suppressor TRNA-mediated rescue of hERG LQTS2 nonsense mutations. Biophysical Journal, 121(3), 177a. https://doi.org/10.1016/j.bpj.2021.11.1853
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