Pancreatic Cancer Research and Treatment

Displaying 1 - 50 of 51CSV
Resell, M., Rabben, H.-L., Sharma, A., Hagen, L., Hoang, L., Skogaker, N. T., Aarvik, A., Bjåstad, E. K., Svensson, M. K., Amrutkar, M., Verbeke, C. S., Batra, S. K., Qvigstad, G., Wang, T. C., Rustgi, A., Chen, D., & Zhao, C.-M. (2025). Proteomics profiling of research models for studying pancreatic ductal adenocarcinoma. Scientific Data, 12(1). https://doi.org/10.1038/s41597-025-04522-x
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Patel, S. H., Colby, S., Sohal, D., Guthrie, K. A., Kachnic, L. A., Chiorean, E. G., Lowy, A. M., Rocha, F. G., Hochster, H. S., Philip, P. A., & Ahmad, S. A. (2025). Chemotherapy dose density is prognostic for overall survival in patients with resectable pancreas cancer: A landmark analysis of SWOG 1505. Cancer, 131(4). Portico. https://doi.org/10.1002/cncr.35759
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Nishiwaki, N., Sugiura, K., Suzuki, K., Li, A. L., Contreras, C. T., Efe, G., Shin, A. E., Sadeghian, D., Zhao, J., Maitra, A., Pitarresi, J. R., Sims, P. A., Chandwani, R., & Rustgi, A. K. (2024). PRRX1 has functional roles in pancreatic acinar to ductal metaplasia and carcinogenesis. Cellular and Molecular Gastroenterology and Hepatology, 101442. https://doi.org/10.1016/j.jcmgh.2024.101442
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Su, S. H., Mitani, Y., Li, T., Sachdeva, U., Flashner, S., Klein-Szanto, A., Dunbar, K. J., Abrams, J., Nakagawa, H., & Gabre, J. (2024). Lactate Suppresses Growth of Esophageal Adenocarcinoma Patient-Derived Organoids through Alterations in Tumor NADH/NAD+ Redox State. Biomolecules, 14(9), 1195. https://doi.org/10.3390/biom14091195
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Connelly, C. F., Towne, W. S., Desai, N., Smithgall, M. C., Cimic, A., & Baskota, S. U. (2024). Cytologic testing for mismatch repair deficiency/microsatellite instability and NTRK gene fusion is not routinely indicated in primary pancreaticobiliary carcinoma cell block material. Journal of the American Society of Cytopathology. https://doi.org/10.1016/j.jasc.2024.08.130
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Saeki, K., Wood, I. S., Wang, W. C. K., Patil, S., Sun, Y., Schaeffer, D. F., Su, G. H., & Kopp, J. L. (2024). Acvr1b Loss Increases Formation of Pancreatic Precancerous Lesions From Acinar and Ductal Cells of Origin. Cellular and Molecular Gastroenterology and Hepatology, 18(5), 101387. https://doi.org/10.1016/j.jcmgh.2024.101387
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Frank, J. S., Thomas, A. S., & Kluger, M. D. (2024). The role of CT imaging in proposed algorithm for managing post-operative hemorrhage after pancreaticoduodenectomy: case series. Surgery Case Reports, 3, 100042. https://doi.org/10.1016/j.sycrs.2024.100042
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Faber, E. B., Baca, Y., Xiu, J., Walker, P., Manji, G., Gholami, S., Saeed, A., Prakash, A., Botta, G. P., Sohal, D., Lenz, H. J., Shields, A. F., Nabhan, C., El-Deiry, W., Seeber, A., Chiu, V., Hwang, J., & Lou, E. (2024). Exploring the differences in the tumor microenvironment and immuno-oncologic targets in pancreatic ductal adenocarcinomas (PDAC) according to KRAS mutational status. ESMO Gastrointestinal Oncology, 4, 100042. https://doi.org/10.1016/j.esmogo.2024.100042
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Karloski, E., Dudley, B., Diergaarde, B., Blanco, A., Everett, J. N., Levinson, E., Rangarajan, T., Stanich, P. P., Childers, K., Brown, S., Drogan, C., Cavestro, G. M., Gordon, K., Singh, A., Simeone, D. M., Reich, H., Kastrinos, F., Zakalik, D., Hampel, H., … Brand, R. E. (2024). The role of family history in predicting germline pathogenic variant carriers who develop pancreatic cancer: Results of a multicenter collaboration. Cancer. Portico. https://doi.org/10.1002/cncr.35383
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Wasko, U. N., Jiang, J., Dalton, T. C., Curiel-Garcia, A., Edwards, A. C., Wang, Y., Lee, B., Orlen, M., Tian, S., Stalnecker, C. A., Drizyte-Miller, K., Menard, M., Dilly, J., Sastra, S. A., Palermo, C. F., Hasselluhn, M. C., Decker-Farrell, A. R., Chang, S., Jiang, L., … Olive, K. P. (2024). Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer. Nature, 629(8013), 927–936. https://doi.org/10.1038/s41586-024-07379-z
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Zogopoulos, G., Haimi, I., Sanoba, S. A., Everett, J. N., Wang, Y., Katona, B. W., Farrell, J. J., Grossberg, A. J., Paiella, S., Klute, K. A., Bi, Y., Wallace, M. B., Kwon, R. S., Stoffel, E. M., Wadlow, R. C., Sussman, D. A., Merchant, N. B., Permuth, J. B., Golan, T., … __. (2024). The Pancreatic Cancer Early Detection (PRECEDE) Study is a Global Effort to Drive Early Detection: Baseline Imaging Findings in High-Risk Individuals. Journal of the National Comprehensive Cancer Network, 22(3), 158–166. https://doi.org/10.6004/jnccn.2023.7097
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Saqi, A., Nishino, M., Saieg, M., Ly, A., & Lott Limbach, A. (2024). Doing more with less: integrating small biopsies in cytology practice. Journal of the American Society of Cytopathology, 13(4), 233–243. https://doi.org/10.1016/j.jasc.2024.03.005
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Ross, A. B., Gorhe, D., Kim, J. K., Hodapp, S., DeVine, L., Chan, K. M., Chio, I. I. C., Jovanovic, M., & Ayres Pereira, M. (2024). Systematic analysis of proteome turnover in an organoid model of pancreatic cancer by dSILO. Cell Reports Methods, 4(5), 100760. https://doi.org/10.1016/j.crmeth.2024.100760
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Ben-Ami, R., Wang, Q.-L., Zhang, J., Supplee, J. G., Fahrmann, J. F., Lehmann-Werman, R., Brais, L. K., Nowak, J., Yuan, C., Loftus, M., Babic, A., Irajizad, E., Davidi, T., Zick, A., Hubert, A., Neiman, D., Piyanzin, S., Gal-Rosenberg, O., Horn, A., … Wolpin, B. M. (2023). Protein biomarkers and alternatively methylated cell-free DNA detect early stage pancreatic cancer. Gut, gutjnl-2023-331074. https://doi.org/10.1136/gutjnl-2023-331074
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Vujasinovic, M., Elbe, P., Ekheden, I., Wang, Q.-L., Thuresson, M., Roelstraete, B., Ghazi, S., Löhr, J.-M., & Ludvigsson, J. F. (2024). Gastrointestinal cancer precursor risk and mortality in pancreatic intraductal papillary mucinous neoplasms: a nationwide cohort study. Scandinavian Journal of Gastroenterology, 59(5), 600–607. https://doi.org/10.1080/00365521.2024.2310162
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Tchouta, L. N., & Schrope, B. A. (2023). Evolving Technique for Puestow-Type Procedure for Chronic Pancreatitis: The Combined Roux-en-Y Proximal End-to-Side and Distal Longitudinal Pancreatojejunostomy. American Journal of Case Reports, 25. https://doi.org/10.12659/ajcr.942066
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Elmi, N., McEvoy, D., McInnes, M. D. F., Alabousi, M., Hecht, E. M., Luk, L., Asghar, S., Jajodia, A., de Carvalho, T. L., Warnica, W. J., Zha, N., Ullah, S., & van der Pol, C. B. (2023). Percentage of Pancreatic Cysts on MRI With a Pancreatic Carcinoma: Systematic Review and Meta‐Analysis. Journal of Magnetic Resonance Imaging. Portico. https://doi.org/10.1002/jmri.29168
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Decker-Farrell, A. R., Ma, A., Li, F., Muir, A., & Olive, K. P. (2023). Generation and ex vivo culture of murine and human pancreatic ductal adenocarcinoma tissue slice explants. STAR Protocols, 4(4), 102711. https://doi.org/10.1016/j.xpro.2023.102711
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Park, J., Lim, F., Prest, M., Ferris, J. S., Aziz, Z., Agyekum, A., Wagner, S., Gulati, R., & Hur, C. (2023). Quantifying the potential benefits of early detection for pancreatic cancer through a counterfactual simulation modeling analysis. Scientific Reports, 13(1). https://doi.org/10.1038/s41598-023-46751-3
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Rajbhandari, N., Hamilton, M., Quintero, C. M., Ferguson, L. P., Fox, R., Schürch, C. M., Wang, J., Nakamura, M., Lytle, N. K., McDermott, M., Diaz, E., Pettit, H., Kritzik, M., Han, H., Cridebring, D., Wen, K. W., Tsai, S., Goggins, M. G., Lowy, A. M., … Reya, T. (2023). Single-cell mapping identifies MSI+ cells as a common origin for diverse subtypes of pancreatic cancer. Cancer Cell, 41(11), 1989-2005.e9. https://doi.org/10.1016/j.ccell.2023.09.008
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Lee, E., O’Keefe, S., Leong, A., Park, H.-R., Varadarajan, J., Chowdhury, S., Hiner, S., Kim, S., Shiva, A., Friedman, R. A., Remotti, H., Fojo, T., Yang, H. W., Thurston, G., & Kim, M. (2023). Angiopoietin-2 blockade suppresses growth of liver metastases from pancreatic neuroendocrine tumors by promoting T cell recruitment. Journal of Clinical Investigation, 133(20). https://doi.org/10.1172/jci167994
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El Menabawey, T., Mulay, A., Graham, D., Phillpotts, S., Sethi, A., & Webster, G. J. (2023). Predictors of success of conventional ERCP for bile duct stones and need for single-operator cholangioscopy. Endoscopy International Open, 11(10), E943–E951. CLOCKSS. https://doi.org/10.1055/a-2164-8557
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Connelly, C., Towne, W., Smithgall, M., Cimic, A., & Baskota, S. U. (2023). Pan-TRK Immunostain for Primary Pancreaticobiliary Carcinomas in Cell Block: A Detailed Study of 233 Cases. Journal of the American Society of Cytopathology, 12(5), S47. https://doi.org/10.1016/j.jasc.2023.07.083
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Irajizad, E., Kenney, A., Tang, T., Vykoukal, J., Wu, R., Murage, E., Dennison, J. B., Sans, M., Long, J. P., Loftus, M., Chabot, J. A., Kluger, M. D., Kastrinos, F., Brais, L., Babic, A., Jajoo, K., Lee, L. S., Clancy, T. E., Ng, K., … Fahrmann, J. F. (2023). A blood-based metabolomic signature predictive of risk for pancreatic cancer. Cell Reports Medicine, 4(9), 101194. https://doi.org/10.1016/j.xcrm.2023.101194
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Manji, G. A., Labadie, B. W., Lee, S. M., Pellicciotta, I., Ge, L., Sta Ana, S., Sender, N., Ross, I., Wong, W., & Raufi, A. G. (2023). MEKiAUTO: A multicenter phase 1 study of combination therapy with the MEK inhibitor, cobimetinib, immune checkpoint blockade, atezolizumab, and the autophagy inhibitor hydroxychloroquine (HCQ) in KRAS-mutated advanced malignancies. JCO Global Oncology, 9(Supplement_1), 45–45. https://doi.org/10.1200/go.2023.9.supplement_1.45
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Ko, A. H., Kim, K.-P., Siveke, J. T., Lopez, C. D., Lacy, J., O’Reilly, E. M., Macarulla, T., Manji, G. A., Lee, J., Ajani, J., Alsina Maqueda, M., Rha, S.-Y., Lau, J., Al-Sakaff, N., Allen, S., Lu, D., Shemesh, C. S., Gan, X., Cha, E., & Oh, D.-Y. (2023). Atezolizumab Plus PEGPH20 Versus Chemotherapy in Advanced Pancreatic Ductal Adenocarcinoma and Gastric Cancer: MORPHEUS Phase Ib/II Umbrella Randomized Study Platform. The Oncologist, 28(6), 553-e472. https://doi.org/10.1093/oncolo/oyad022
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Perez, K., Chiarella, A. M., Cleary, J. M., Horick, N., Weekes, C., Abrams, T., Blaszkowsky, L., Enzinger, P., Giannakis, M., Goyal, L., Meyerhardt, J. A., Rubinson, D., Yurgelun, M. B., Goessling, W., Giantonio, B. J., Brais, L., Germon, V., Stonely, D., Raghavan, S., … Wolpin, B. M. (2023). Phase Ib and Expansion Study of Gemcitabine,Nab-Paclitaxel, and Ficlatuzumab in Patients With Metastatic Pancreatic Cancer. The Oncologist, 28(5), 425–432. https://doi.org/10.1093/oncolo/oyad002
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Dercle, L., Fronheiser, M., Rizvi, N. A., Hellmann, M. D., Maier, S., Hayes, W., Yang, H., Guo, P., Fojo, T., Schwartz, L. H., Zhao, B., & Leung, D. K. (2023). Baseline Radiomic Signature to Estimate Overall Survival in Patients With NSCLC. Journal of Thoracic Oncology, 18(5), 587–598. https://doi.org/10.1016/j.jtho.2022.12.019
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Fulop, D. J., Zylberberg, H. M., Wu, Y. L., Aronson, A., Labiner, A. J., Wisnivesky, J., Cohen, D. J., Sigel, K. M., & Lucas, A. L. (2023). Association of Antibiotic Receipt With Survival Among Patients With Metastatic Pancreatic Ductal Adenocarcinoma Receiving Chemotherapy. JAMA Network Open, 6(3), e234254. https://doi.org/10.1001/jamanetworkopen.2023.4254
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Yeh, C., Zhou, M., Sigel, K., Jameson, G., White, R., Safyan, R., Saenger, Y., Hecht, E., Chabot, J., Schreibman, S., Juzyna, B., Ychou, M., Conroy, T., Fojo, T., Manji, G. A., Von Hoff, D., & Bates, S. E. (2022). Tumor Growth Rate Informs Treatment Efficacy in Metastatic Pancreatic Adenocarcinoma: Application of a Growth and Regression Model to Pivotal Trial and Real-World Data. The Oncologist, 28(2), 139–148. https://doi.org/10.1093/oncolo/oyac217
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Parejo-Alonso, B., Royo-García, A., Espiau-Romera, P., Courtois, S., Curiel-García, Á., Zagorac, S., Villaoslada, I., Olive, K. P., Heeschen, C., & Sancho, P. (2023). Pharmacological targeting of the receptor ALK inhibits tumorigenicity and overcomes chemoresistance in pancreatic ductal adenocarcinoma. Biomedicine & Pharmacotherapy, 158, 114162. https://doi.org/10.1016/j.biopha.2022.114162
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Gartrell, R. D., Enzler, T., Kim, P. S., Fullerton, B. T., Fazlollahi, L., Chen, A. X., Minns, H. E., Perni, S., Weisberg, S. P., Rizk, E. M., Wang, S., Oh, E. J., Guo, X. V., Chiuzan, C., Manji, G. A., Bates, S. E., Chabot, J., Schrope, B., Kluger, M., … Saenger, Y. M. (2022). Neoadjuvant chemoradiation alters the immune microenvironment in pancreatic ductal adenocarcinoma. OncoImmunology, 11(1). https://doi.org/10.1080/2162402x.2022.2066767
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Cordo’, V., Meijer, M. T., Hagelaar, R., de Goeij-de Haas, R. R., Poort, V. M., Henneman, A. A., Piersma, S. R., Pham, T. V., Oshima, K., Ferrando, A. A., Zaman, G. J. R., Jimenez, C. R., & Meijerink, J. P. P. (2022). Phosphoproteomic profiling of T cell acute lymphoblastic leukemia reveals targetable kinases and combination treatment strategies. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-28682-1
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Columbia Affiliation
Curiel-Garcia, A., Decker-Farrell, A. R., Sastra, S. A., & Olive, K. P. (2022). Generation of orthotopic patient-derived xenograft models for pancreatic cancer using tumor slices. STAR Protocols, 3(4), 101899. https://doi.org/10.1016/j.xpro.2022.101899
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Bauer, T., Cho, B. C., Heist, R., Bazhenova, L., Werner, T., Goel, S., Kim, D.-W., Adkins, D., Carvajal, R. D., Alva, A., Eaton, K., Wang, J., Liu, Y., Yan, X., Christensen, J., Neuteboom, S., Chao, R., & Pant, S. (2022). First-in-human phase 1/1b study to evaluate sitravatinib in patients with advanced solid tumors. Investigational New Drugs, 40(5), 990–1000. https://doi.org/10.1007/s10637-022-01274-y
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Perdigoto, A. L., Deng, S., Du, K. C., Kuchroo, M., Burkhardt, D. B., Tong, A., Israel, G., Robert, M. E., Weisberg, S. P., Kirkiles-Smith, N., Stamatouli, A. M., Kluger, H. M., Quandt, Z., Young, A., Yang, M.-L., Mamula, M. J., Pober, J. S., Anderson, M. S., Krishnaswamy, S., & Herold, K. C. (2022). Immune cells and their inflammatory mediators modify β cells and cause checkpoint inhibitor–induced diabetes. JCI Insight, 7(17). https://doi.org/10.1172/jci.insight.156330
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Yap, T. A., Moore, K. N., Patel, M., Henick, B. S., Do, D., Iheanacho, A., Zhang, H., Roche, M., Newberry, K., Hsieh, A., & Juric, D. (2022). 491TiP A first-in-human phase I/II study of BLU-222, a potent, selective CDK2 inhibitor in patients with CCNE1-amplified or CDK4/6 inhibitor-resistant advanced solid tumors. Annals of Oncology, 33, S765. https://doi.org/10.1016/j.annonc.2022.07.619
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Ingram, M. A., Lauren, B. N., Pumpalova, Y., Park, J., Lim, F., Bates, S. E., Kastrinos, F., Manji, G. A., Kong, C. Y., & Hur, C. (2022). Cost‐effectiveness of neoadjuvant FOLFIRINOX versus gemcitabine plus nab‐paclitaxel in borderline resectable/locally advanced pancreatic cancer patients. Cancer Reports, 5(9). Portico. https://doi.org/10.1002/cnr2.1565
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Sanborn, R. E., Pishvaian, M. J., Callahan, M. K., Weise, A., Sikic, B. I., Rahma, O., Cho, D. C., Rizvi, N. A., Sznol, M., Lutzky, J., Bauman, J. E., Bitting, R. L., Starodub, A., Jimeno, A., Reardon, D. A., Kaley, T., Iwamoto, F., Baehring, J. M., Subramaniam, D. S., … Keler, T. (2022). Safety, tolerability and efficacy of agonist anti-CD27 antibody (varlilumab) administered in combination with anti-PD-1 (nivolumab) in advanced solid tumors. Journal for ImmunoTherapy of Cancer, 10(8), e005147. https://doi.org/10.1136/jitc-2022-005147
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Scales, M. K., Velez-Delgado, A., Steele, N. G., Schrader, H. E., Stabnick, A. M., Yan, W., Mercado Soto, N. M., Nwosu, Z. C., Johnson, C., Zhang, Y., Salas-Escabillas, D. J., Menjivar, R. E., Maurer, H. C., Crawford, H. C., Bednar, F., Olive, K. P., Pasca di Magliano, M., & Allen, B. L. (2022). Combinatorial Gli activity directs immune infiltration and tumor growth in pancreatic cancer. PLOS Genetics, 18(7), e1010315. https://doi.org/10.1371/journal.pgen.1010315
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Park, J., Artin, M. G., Lee, K. E., Pumpalova, Y. S., Ingram, M. A., May, B. L., Park, M., Hur, C., & Tatonetti, N. P. (2022). Deep learning on time series laboratory test results from electronic health records for early detection of pancreatic cancer. Journal of Biomedical Informatics, 131, 104095. https://doi.org/10.1016/j.jbi.2022.104095
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Caplan, L. R., Vavinskaya, V., Gelikman, D. G., Jyotsana, N., Trinh, V. Q., Olive, K. P., Tan, M. C. B., & DelGiorno, K. E. (2022). Enteroendocrine Cell Formation Is an Early Event in Pancreatic Tumorigenesis. Frontiers in Physiology, 13. https://doi.org/10.3389/fphys.2022.865452
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Rustgi, S. D., Zylberberg, H. M., Amin, S., Aronson, A., Nagula, S., DiMaio, C. J., Kumta, N. A., & Lucas, A. L. (2022). Use of endoscopic ultrasound for pancreatic cancer from 2000 to 2016. Endoscopy International Open, 10(01), E19–E29. CLOCKSS. https://doi.org/10.1055/a-1608-0856
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Thomas, A., Huang, Y., Schrope, B., Sugahara, K., Chabot, J., Wright, J., & Kluger, M. (2022). Prevalence of Diabetes and Pancreatic Insufficiency Plateau within Six Months of Pancreatectomy. HPB, 24, S66–S67. https://doi.org/10.1016/j.hpb.2022.05.123
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Thomas, A., Kwon, W., Tehranifar, P., Sugahara, K., Schrope, B., Chabot, J., Genkinger, J., & Kluger, M. (2022). Barriers to Standard of Care in the United States: Trends in the Treatment of Locally Advanced Pancreatic Cancer in the Modern Era of Chemotherapy. HPB, 24, S36. https://doi.org/10.1016/j.hpb.2022.05.071
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