U01DK062422

NIH – National Institute of Diabetes and Digestive and Kidney Diseases

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NOX1 is essential for TNFα-induced intestinal epithelial ROS secretion and inhibits M cell signatures

Hsu, N.-Y., Nayar, S., Gettler, K., Talware, S., Giri, M., Alter, I., Argmann, C., Sabic, K., Thin, T. H., Ko, H.-B. M., Werner, R., Tastad, C., Stappenbeck, T., Azabdaftari, A., Uhlig, H. H., Chuang, L.-S., & Cho, J. H. (2022). NOX1 is essential for TNFα-induced intestinal epithelial ROS secretion and inhibits M cell signatures. Gut, 72(4), 654–662. https://doi.org/10.1136/gutjnl-2021-326305
Authors:
Nai-Yun Hsu
Shikha Nayar
Kyle Gettler
Sayali Talware
Mamta Giri
Isaac Alter
Carmen Argmann
Ksenija Sabic
Tin Htwe Thin
Huai-Bin Mabel Ko
Robert Werner
Christopher Tastad
Thaddeus Stappenbeck
Aline Azabdaftari
Holm H Uhlig
Ling-Shiang Chuang
Judy H Cho
Affiliated Authors:
Huai-Bin Mabel Ko
Columbia Affiliation:
Subjects:
Colitis (MeSH)
Inflammatory Bowel Diseases (MeSH)
Author Keywords:
ibd
genetics
epithelial cells
ulcerative colitis
intestinal stem cell
ibd - genetics
Grants:
U24DK062429 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
R01DK106593 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
R01DK123758 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
U01DK062422 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
Publication Type:
Article
Unique ID:
10.1136/gutjnl-2021-326305
PMID:
36191961
DOI:
10.1136/gutjnl-2021-326305
Journal:
Gut
Publication Date:
Data Source:
PubMed
Source Link:
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Record Created:

Stratification of risk of progression to colectomy in ulcerative colitis via measured and predicted gene expression

Mo, A., Nagpal, S., Gettler, K., Haritunians, T., Giri, M., Haberman, Y., Karns, R., Prince, J., Arafat, D., Hsu, N.-Y., Chuang, L.-S., Argmann, C., Kasarskis, A., Suarez-Farinas, M., Gotman, N., Mengesha, E., Venkateswaran, S., Rufo, P. A., Baker, S. S., … Gibson, G. (2021). Stratification of risk of progression to colectomy in ulcerative colitis via measured and predicted gene expression. The American Journal of Human Genetics, 108(9), 1765–1779. https://doi.org/10.1016/j.ajhg.2021.07.013
Authors:
Angela Mo
Sini Nagpal
Kyle Gettler
Talin Haritunians
Mamta Giri
Yael Haberman
Rebekah Karns
Jarod Prince
Dalia Arafat
Nai-Yun Hsu
Ling-Shiang Chuang
Carmen Argmann
Andrew Kasarskis
Mayte Suarez-Farinas
Nathan Gotman
Emebet Mengesha
Suresh Venkateswaran
Paul A. Rufo
Susan S. Baker
Cary G. Sauer
James Markowitz
Marian D. Pfefferkorn
Joel R. Rosh
Brendan M. Boyle
David R. Mack
Robert N. Baldassano
Sapana Shah
Neal S. LeLeiko
Melvin B. Heyman
Anne M. Griffiths
Ashish S. Patel
Joshua D. Noe
Sonia Davis Thomas
Bruce J. Aronow
Thomas D. Walters
Dermot P.B. McGovern
Jeffrey S. Hyams
Subra Kugathasan
Judy H. Cho
Lee A. Denson
Greg Gibson
Affiliated Authors:
Neal S. LeLeiko
Columbia Affiliation:
Author Keywords:
cell-type-specific gene expression
eqtls
predicted polygenic transcriptional risk scores
prediction of disease progression
transcriptional risk scores
transcriptome-wide association studies
Grants:
U01DK062422 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
U01DK095745 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
U24DK062429 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
P30DK078392 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
P01DK046763 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
R01DK119991 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
U01DK062413 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
Publication Type:
Article
Unique ID:
10.1016/j.ajhg.2021.07.013
PMID:
34450030
DOI:
10.1016/j.ajhg.2021.07.013
Journal:
American Journal of Human Genetics
Publication Date:
Data Source:
Scopus
Source Link:
View Scopus Record

Record Created:

Novel ultra-rare exonic variants identified in a founder population implicate cadherins in schizophrenia

Lencz, T., Yu, J., Khan, R. R., Flaherty, E., Carmi, S., Lam, M., Ben-Avraham, D., Barzilai, N., Bressman, S., Darvasi, A., Cho, J. H., Clark, L. N., Gümüş, Z. H., Vijai, J., Klein, R. J., Lipkin, S., Offit, K., Ostrer, H., Ozelius, L. J., … Pe’er, I. (2021). Novel ultra-rare exonic variants identified in a founder population implicate cadherins in schizophrenia. Neuron, 109(9), 1465-1478.e4. https://doi.org/10.1016/j.neuron.2021.03.004
Authors:
Todd Lencz
Anil K. Malhotra
Jin Yu
Max Lam
Itsik Pe'er
Raiyan Rashid Khan
Erin Flaherty
Shai Carmi
Danny Ben-Avraham
Nir Barzilai
Gil Atzmon
Susan Bressman
Ariel Darvasi
Judy H. Cho
Zeynep H. Gumus
Robert J. Klein
Inga Peter
Lorraine N. Clark
Joseph Vijai
Kenneth Offit
Steven Lipkin
Harry Ostrer
Laurie J. Ozelius
Tom Maniatis
Affiliated Authors:
Itsik Pe'er
Raiyan Rashid Khan
Erin Flaherty
Lorraine N. Clark
Columbia Affiliation:
Subjects:
Cadherins (MeSH)
Genetic Predisposition to Disease (MeSH)
Schizophrenia (MeSH)
Wnt Signaling in Development and Disease (OpenAlex Topic)
Genomic Studies and Association Analyses (OpenAlex Topic)
Genetic Research on BRCA Mutations and Cancer Risk (OpenAlex Topic)
Author Keywords:
cadherins
exome
founder population
rare variants
schizophrenia
Grants:
U54CA121852 (NIH – National Cancer Institute)
R01DK092235 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
U01DK062422 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
U24DK062429 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
U01DK062429 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
R01MH114817 (NIH – National Institute of Mental Health)
R01MH108579 (NIH – National Institute of Mental Health)
R01MH095458 (NIH – National Institute of Mental Health)
R01MH084098 (NIH – National Institute of Mental Health)
RC2MH089964 (NIH – National Institute of Mental Health)
R01NS060113 (NIH – National Institute of Neurological Disorders and Stroke)
P30AG038072 (NIH – National Institute On Aging)
P01AG027734 (NIH – National Institute On Aging)
R01AG042188 (NIH – National Institute On Aging)
Publication Type:
Article
Unique ID:
10.1016/j.neuron.2021.03.004
PMID:
33756103
DOI:
10.1016/j.neuron.2021.03.004
Journal:
Neuron
Publication Date:
Data Source:
Web of Science
Source Link:
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Record Created:

A myeloid-stromal niche and gp130 rescue in NOD2-driven Crohn's disease

Nayar, S., Morrison, J. K., Giri, M., Gettler, K., Chuang, L., Walker, L. A., Ko, H. M., Kenigsberg, E., Kugathasan, S., Merad, M., Chu, J., & Cho, J. H. (2021). A myeloid–stromal niche and gp130 rescue in NOD2-driven Crohn’s disease. Nature, 593(7858), 275–281. https://doi.org/10.1038/s41586-021-03484-5
Authors:
Shikha Nayar
Joshua K Morrison
Mamta Giri
Kyle Gettler
Ling-Shiang Chuang
Laura A Walker
Huaibin M Ko
Ephraim Kenigsberg
Subra Kugathasan
Miriam Merad
Jaime Chu
Judy H Cho
Affiliated Authors:
Huaibin M Ko
Columbia Affiliation:
Subjects:
Crohn Disease (MeSH)
Cytokine Receptor gp130 (MeSH)
Myeloid Cells (MeSH)
Nod2 Signaling Adaptor Protein (MeSH)
Stromal Cells (MeSH)
Grants:
R01DK121154 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
R01DK123758 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
R01DK106593 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
U01DK062422 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
Publication Type:
Article
Unique ID:
10.1038/s41586-021-03484-5
PMID:
33789339
DOI:
10.1038/s41586-021-03484-5
Journal:
Nature
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View Scopus Record
View Web of Science Record

Record Created:

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