CUIMC Publications

Mechanisms linking cerebrovascular dysfunction and tauopathy: Adding a layer of epiregulatory complexity

Record Created:

Monday, August 12, 2024 - 12:14

Kim, Y. A., Mellen, M., Kizil, C., & Santa‐Maria, I. (2023). Mechanisms linking cerebrovascular dysfunction and tauopathy: Adding a layer of epiregulatory complexity. British Journal of Pharmacology, 181(6), 879–895. Portico. https://doi.org/10.1111/bph.16280

Authors:

Yoon A Kim

Marian Mellen

Caghan Kizil

Ismael Santa-Maria

Affiliated Authors:

Yoon A Kim

Caghan Kizil

Ismael Santa-Maria

Columbia Affiliation:

Subjects:

Alzheimer Disease (MeSH)

Tauopathies (MeSH)

Author Keywords:

cerebrovascular

epigenetics

epitranscriptomics

neuroinflammation

tauopathy

therapeutic

Publication Type:

Article

Unique ID:

10.1111/bph.16280

PMID:

37926507

DOI:

10.1111/bph.16280

Journal:

British Journal of Pharmacology

Publication Date:

2023-12-26

Data Source:

PubMed

Source Link:

Focusing on oligomeric tau as a therapeutic target in Alzheimer's disease and other tauopathies

Record Created:

Sunday, July 28, 2024 - 21:15

Rayman, J. B. (2023). Focusing on oligomeric tau as a therapeutic target in Alzheimer’s disease and other tauopathies. Expert Opinion on Therapeutic Targets, 27(4–5), 269–279. https://doi.org/10.1080/14728222.2023.2206561

Authors:

Joseph B Rayman

Affiliated Authors:

Joseph B Rayman

Columbia Affiliation:

Vagelos College of Physicians and Surgeons
- Department of Medicine
- Department of Psychiatry
  Division of Experimental Therapeutics

Subjects:

Alzheimer Disease (MeSH)

Supranuclear Palsy, Progressive (MeSH)

Tauopathies (MeSH)

Author Keywords:

alzheimer’s disease

frontotemporal dementia

neurodegeneration

oligomeric tau

progressive supranuclear palsy

tau

tauopathies

therapeutics

Publication Type:

Article

Unique ID:

10.1080/14728222.2023.2206561

PMID:

37140480

DOI:

10.1080/14728222.2023.2206561

Journal:

Expert Opinion on Therapeutic Targets

Publication Date:

2023-06-15

Data Source:

PubMed

Source Link:

Mitochondrial oxidative stress contributes to the pathological aggregation and accumulation of tau oligomers in Alzheimer's disease

Record Created:

Tuesday, August 13, 2024 - 11:42

Du, F., Yu, Q., Kanaan, N. M., & Yan, S. S. (2022). Mitochondrial oxidative stress contributes to the pathological aggregation and accumulation of tau oligomers in Alzheimer’s disease. Human Molecular Genetics, 31(15), 2498–2507. https://doi.org/10.1093/hmg/ddab363

Authors:

Fang Du

Qing Yu

Nicholas M. Kanaan

Shirley ShiDu Yan

Affiliated Authors:

Fang Du

Qing Yu

Shirley ShiDu Yan

Columbia Affiliation:

Vagelos College of Physicians and Surgeons

Subjects:

Alzheimer Disease (MeSH)

Tauopathies (MeSH)

Grants:

RF1AG054320 (NIH – National Institute On Aging)

R01AG069426 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1093/hmg/ddab363

PMID:

35165721

DOI:

10.1093/hmg/ddab363

Journal:

Human Molecular Genetics

Publication Date:

2022-08-01

Data Source:

Scopus

Source Link:

Sauna-like conditions or menthol treatment reduce tau phosphorylation through mild hyperthermia

Record Created:

Thursday, December 12, 2024 - 15:22

Guisle, I., Canet, G., Pétry, S., Fereydouni-Forouzandeh, P., Morin, F., Kérauden, R., Whittington, R. A., Calon, F., Hébert, S. S., & Planel, E. (2022). Sauna-like conditions or menthol treatment reduce tau phosphorylation through mild hyperthermia. Neurobiology of Aging, 113, 118–130. https://doi.org/10.1016/j.neurobiolaging.2022.02.011

Authors:

Isabelle Guisle

Geoffrey Canet

Séréna Pétry

Parissa Fereydouni-Forouzandeh

Françoise Morin

Rémi Kérauden

Robert A. Whittington

Frédéric Calon

Sébastien S. Hébert

Emmanuel Planel

Affiliated Authors:

Robert A. Whittington

Columbia Affiliation:

Vagelos College of Physicians and Surgeons
- Department of Anesthesiology

Subjects:

Alzheimer Disease (MeSH)

Steam Bath (MeSH)

Tauopathies (MeSH)

Author Keywords:

alzheimer's disease

tau protein phosphorylation

sauna bathing

menthol

hyperthermia

thermogenesis

Publication Type:

Article

Unique ID:

10.1016/j.neurobiolaging.2022.02.011

PMID:

35334439

DOI:

10.1016/j.neurobiolaging.2022.02.011

Journal:

Neurobiology of Aging

Publication Date:

2022-05-01

Data Source:

Scopus

Source Link:

Wolframin is a novel regulator of tau pathology and neurodegeneration

Record Created:

Wednesday, February 12, 2025 - 09:26

Chen, S., Acosta, D., Li, L., Liang, J., Chang, Y., Wang, C., Fitzgerald, J., Morrison, C., Goulbourne, C. N., Nakano, Y., Villegas, N. C. H., Venkataraman, L., Brown, C., Serrano, G. E., Bell, E., Wemlinger, T., Wu, M., Kokiko-Cochran, O. N., Popovich, P., … Fu, H. (2022). Wolframin is a novel regulator of tau pathology and neurodegeneration. Acta Neuropathologica, 143(5), 547–569. https://doi.org/10.1007/s00401-022-02417-4

Authors:

Shuo Chen

Diana Acosta

Liangping Li

Jiawen Liang

Yuzhou Chang

Cankun Wang

Julie Fitzgerald

Cody Morrison

Chris N. Goulbourne

Yoshi Nakano

Nancy C. Hernandez Villegas

Lalitha Venkataraman

Cris Brown

Geidy E. Serrano

Erica Bell

Trina Wemlinger

Min Wu

Olga N. Kokiko-Cochran

Phillip Popovich

Xena E. Flowers

Lawrence S. Honig

Jean Paul Vonsattel

Douglas W. Scharre

Thomas G. Beach

Qin Ma

Jeff Kuret

Sulev Kõks

Fumihiko Urano

Karen E. Duff

Hongjun Fu

Affiliated Authors:

Yoshi Nakano

Nancy C. Hernandez Villegas

Xena E. Flowers

Lawrence S. Honig

Jean Paul Vonsattel

Karen E. Duff

Columbia Affiliation:

Vagelos College of Physicians and Surgeons
- Department of Pathology and Cell Biology
- Department of Neurology

Subjects:

Alzheimer Disease (MeSH)

Tauopathies (MeSH)

Author Keywords:

wolframin

wfs1

tau pathology

neuronal vulnerability

alzheimer's disease

neurodegeneration

er stress

autophagy-lysosome pathway

entorhinal cortex

alzheimer’s disease

Grants:

P30DK020579 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

R01GM131399 (NIH – National Institute of General Medical Sciences)

K01AG056673 (NIH – National Institute On Aging)

R56AG066782 (NIH – National Institute On Aging)

R01AG075092 (NIH – National Institute On Aging)

R01AG014452 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1007/s00401-022-02417-4

PMID:

35389045

DOI:

10.1007/s00401-022-02417-4

Journal:

Acta Neuropathologica

Publication Date:

2022-05-01

Data Source:

Scopus

Source Link:

Genome-wide association study and functional validation implicates JADE1 in tauopathy

Record Created:

Wednesday, February 12, 2025 - 09:26

Farrell, K., Kim, S., Han, N., Iida, M. A., Gonzalez, E. M., Otero-Garcia, M., Walker, J. M., Richardson, T. E., Renton, A. E., Andrews, S. J., Fulton-Howard, B., Humphrey, J., Vialle, R. A., Bowles, K. R., de Paiva Lopes, K., Whitney, K., Dangoor, D. K., Walsh, H., Marcora, E., … Crary, J. F. (2021). Genome-wide association study and functional validation implicates JADE1 in tauopathy. Acta Neuropathologica, 143(1), 33–53. https://doi.org/10.1007/s00401-021-02379-z

Authors:

Kurt Farrell

SoongHo Kim

Natalia Han

Megan A. Iida

Elias M. Gonzalez

Marcos Otero-Garcia

Jamie M. Walker

Timothy E. Richardson

Alan E. Renton

Shea J. Andrews

Brian Fulton-Howard

Jack Humphrey

Ricardo A. Vialle

Kathryn R. Bowles

Katia de Paiva Lopes

Kristen Whitney

Diana K. Dangoor

Hadley Walsh

Edoardo Marcora

Marco M. Hefti

Alicia Casella

Cheick T. Sissoko

Manav Kapoor

Gloriia Novikova

Evan Udine

Garrett Wong

Weijing Tang

Tushar Bhangale

Julie Hunkapiller

Gai Ayalon

Robert R. Graham

Jonathan D. Cherry

Etty P. Cortes

Valeriy Y. Borukov

Ann C. McKee

Thor D. Stein

Jean-Paul Vonsattel

Andy F. Teich

Marla Gearing

Jonathan Glass

Juan C. Troncoso

Matthew P. Frosch

Bradley T. Hyman

Dennis W. Dickson

Melissa E. Murray

Johannes Attems

Margaret E. Flanagan

Qinwen Mao

M.-Marsel Mesulam

Sandra Weintraub

Randy L. Woltjer

Thao Pham

Julia Kofler

Julie A. Schneider

Lei Yu

Dushyant P. Purohit

Vahram Haroutunian

Patrick R. Hof

Sam Gandy

Mary Sano

Thomas G. Beach

Wayne Poon

Claudia H. Kawas

María M. Corrada

Robert A. Rissman

Jeff Metcalf

Sara Shuldberg

Bahar Salehi

Peter T. Nelson

John Q. Trojanowski

Edward B. Lee

David A. Wolk

Corey T. McMillan

C. Dirk Keene

Caitlin S. Latimer

Thomas J. Montine

Gabor G. Kovacs

Mirjam I. Lutz

Peter Fischer

Richard J. Perrin

Nigel J. Cairns

Erin E. Franklin

Herbert T. Cohen

Towfique Raj

Inma Cobos

Bess Frost

Alison Goate

Charles L. White III

John F. Crary

Affiliated Authors:

Jean-Paul Vonsattel

Andy F. Teich

Columbia Affiliation:

Subjects:

Homeodomain Proteins (MeSH)

Tauopathies (MeSH)

Tumor Suppressor Proteins (MeSH)

Grants:

R01CA079830 (NIH – National Cancer Institute)

UL1TR001414 (NIH – National Center for Advancing Translational Sciences)

R01NS086736 (NIH – National Institute of Neurological Disorders and Stroke)

R01NS095252 (NIH – National Institute of Neurological Disorders and Stroke)

U24NS072026 (NIH – National Institute of Neurological Disorders and Stroke)

K23NS109284 (NIH – National Institute of Neurological Disorders and Stroke)

U54NS115266 (NIH – National Institute of Neurological Disorders and Stroke)

P30NS055077 (NIH – National Institute of Neurological Disorders and Stroke)

P50AG005138 (NIH – National Institute On Aging)

P30AG010124 (NIH – National Institute On Aging)

K99AG070109 (NIH – National Institute On Aging)

P50AG016573 (NIH – National Institute On Aging)

P30AG066444 (NIH – National Institute On Aging)

P30AG010161 (NIH – National Institute On Aging)

R01AG062348 (NIH – National Institute On Aging)

P50AG025688 (NIH – National Institute On Aging)

P30AG066514 (NIH – National Institute On Aging)

P30AG013854 (NIH – National Institute On Aging)

F32AG056098 (NIH – National Institute On Aging)

P01AG026276 (NIH – National Institute On Aging)

K08AG065463 (NIH – National Institute On Aging)

P30AG072946 (NIH – National Institute On Aging)

U01AG006781 (NIH – National Institute On Aging)

R01AG054449 (NIH – National Institute On Aging)

P01AG000538 (NIH – National Institute On Aging)

U01AG058635 (NIH – National Institute On Aging)

RF1AG060961 (NIH – National Institute On Aging)

R01AG066152 (NIH – National Institute On Aging)

P50AG005136 (NIH – National Institute On Aging)

U24AG021886 (NIH – National Institute On Aging)

P30AG008017 (NIH – National Institute On Aging)

P30AG066509 (NIH – National Institute On Aging)

P50AG005134 (NIH – National Institute On Aging)

P01AG017586 (NIH – National Institute On Aging)

P30AG066462 (NIH – National Institute On Aging)

P30AG072979 (NIH – National Institute On Aging)

P50AG005681 (NIH – National Institute On Aging)

U19AG062418 (NIH – National Institute On Aging)

P01AG003991 (NIH – National Institute On Aging)

P50AG008702 (NIH – National Institute On Aging)

P30AG066511 (NIH – National Institute On Aging)

P30AG072977 (NIH – National Institute On Aging)

P30AG066507 (NIH – National Institute On Aging)

P50AG005131 (NIH – National Institute On Aging)

P50AG005146 (NIH – National Institute On Aging)

R01AG059848 (NIH – National Institute On Aging)

P30AG062429 (NIH – National Institute On Aging)

P30AG062421 (NIH – National Institute On Aging)

P30AG066468 (NIH – National Institute On Aging)

R01AG021055 (NIH – National Institute On Aging)

P30AG028383 (NIH – National Institute On Aging)

P30AG072980 (NIH – National Institute On Aging)

P30AG066519 (NIH – National Institute On Aging)

P01AG066597 (NIH – National Institute On Aging)

P30AG019610 (NIH – National Institute On Aging)

R01AG054008 (NIH – National Institute On Aging)

S10OD030463 (NIH – Office of the Director, National Institutes of Health)

S10OD026880 (NIH – Office of the Director, National Institutes of Health)

Publication Type:

Article

Unique ID:

10.1007/s00401-021-02379-z

PMID:

34719765

DOI:

10.1007/s00401-021-02379-z

Journal:

Acta Neuropathologica

Publication Date:

2022-01-01

Data Source:

Scopus

Source Link:

Tau Isoform Profile in Essential Tremor Diverges From Other Tauopathies

Record Created:

Wednesday, February 19, 2025 - 11:45

Kim, S. H., Farrell, K., Cosentino, S., Vonsattel, J.-P. G., Faust, P. L., Cortes, E. P., Bennet, D. A., Louis, E. D., & Crary, J. F. (2021). Tau Isoform Profile in Essential Tremor Diverges From Other Tauopathies. Journal of Neuropathology & Experimental Neurology, 80(9), 835–843. https://doi.org/10.1093/jnen/nlab073

Authors:

Soong Ho Kim

Kurt Farrell

Stephanie Cosentino

Jean-Paul G. Vonsattel

Phyllis L. Faust

Etty P. Cortes

David A. Bennet

Elan D. Louis

John F. Crary

Affiliated Authors:

Stephanie Cosentino

Jean-Paul G. Vonsattel

Phyllis L. Faust

Columbia Affiliation:

Subjects:

Deep Brain Stimulation for Neurological Disorders (OpenAlex Topic)

Mechanisms of Alzheimer's Disease (OpenAlex Topic)

Pathophysiology of Parkinson's Disease (OpenAlex Topic)

Brain (MeSH)

Essential Tremor (MeSH)

Tauopathies (MeSH)

tau Proteins (MeSH)

Author Keywords:

alzheimer disease

essential tremor

neurodegeneration

neurofibrillary tangle

pick disease

progressive supranuclear palsy

tau isoform

tauopathy

Grants:

P30NS055077 (NIH – National Institute of Neurological Disorders and Stroke)

P50AG016573 (NIH – National Institute On Aging)

P50AG005133 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1093/jnen/nlab073

PMID:

34363663

DOI:

10.1093/jnen/nlab073

Journal:

Journal of Neuropathology and Experimental Neurology

Publication Date:

2021-09-01

Data Source:

Scopus

Source Link:

Sex differences in in vivo tau neuropathology in a multiethnic sample of late middle-aged adults

View OpenAlex Record

Record Created:

Tuesday, June 10, 2025 - 10:40

Palta, P., Rippon, B., Tahmi, M., Pardo, M., Johnson, A., Tomljanovic, Z., He, H., Laing, K. K., Razlighi, Q. R., Teresi, J. A., Moreno, H., Brickman, A. M., Kreisl, W. C., & Luchsinger, J. A. (2021). Sex differences in in vivo tau neuropathology in a multiethnic sample of late middle-aged adults. Neurobiology of Aging, 103, 109–116. https://doi.org/10.1016/j.neurobiolaging.2021.03.007

Authors:

Priya Palta

Brady Rippon

Mouna Tahmi

Michelle Pardo

Aubrey Johnson

Zeljko Tomljanovic

Hengda He

Krystal K. Laing

Qolamreza R. Razlighi

Jeanne A. Teresi

Herman Moreno

Adam M. Brickman

William C. Kreisl

José A. Luchsinger

Affiliated Authors:

Priya Palta

Brady Rippon

Mouna Tahmi

Michelle Pardo

Aubrey Johnson

Zeljko Tomljanovic

Hengda He

Krystal K. Laing

Jeanne A. Teresi

Herman Moreno

Adam M. Brickman

William C. Kreisl

José A. Luchsinger

Columbia Affiliation:

Subjects:

Sex Characteristics (MeSH)

Tauopathies (MeSH)

Temporal Lobe (MeSH)

tau Proteins (MeSH)

Author Keywords:

alzheimer's disease

epidemiology

neuroimaging

sex differences

Grants:

UL1TR001873 (NIH – National Center for Advancing Translational Sciences)

R00AG052830 (NIH – National Institute On Aging)

P30AG059303 (NIH – National Institute On Aging)

R01AG050440 (NIH – National Institute On Aging)

K24AG045334 (NIH – National Institute On Aging)

RF1AG051556 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1016/j.neurobiolaging.2021.03.007

PMID:

33894641

DOI:

10.1016/j.neurobiolaging.2021.03.007

Journal:

Neurobiology of Aging

Publication Date:

2021-07-01

Data Source:

Scopus

Source Link:

ApoE4 inhibition of VMAT2 in the locus coeruleus exacerbates Tau pathology in Alzheimer’s disease

Record Created:

Thursday, July 10, 2025 - 15:11

Kang, S. S., Ahn, E. H., Liu, X., Bryson, M., Miller, G. W., Weinshenker, D., & Ye, K. (2021). ApoE4 inhibition of VMAT2 in the locus coeruleus exacerbates Tau pathology in Alzheimer’s disease. Acta Neuropathologica, 142(1), 139–158. https://doi.org/10.1007/s00401-021-02315-1

Authors:

Seong Su Kang

Eun Hee Ahn

Xia Liu

Matthew Bryson

Gary W. Miller

David Weinshenker

Keqiang Ye

Affiliated Authors:

Gary W. Miller

Columbia Affiliation:

Mailman School of Public Health
- Department of Environmental Health Sciences

Subjects:

Alzheimer Disease (MeSH)

Apolipoprotein E4 (MeSH)

Locus Coeruleus (MeSH)

Tauopathies (MeSH)

Vesicular Monoamine Transport Proteins (MeSH)

Author Keywords:

apoe

vmat2

dopegal

norepinephrine

neurofibrillary tangle

locus coeruleus

Grants:

UL1TR002378 (NIH – National Center for Advancing Translational Sciences)

P30NS055077 (NIH – National Institute of Neurological Disorders and Stroke)

RF1AG061175 (NIH – National Institute On Aging)

RF1AG051538 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1007/s00401-021-02315-1

PMID:

33895869

DOI:

10.1007/s00401-021-02315-1

Journal:

Acta Neuropathologica

Publication Date:

2021-07-01

Data Source:

Scopus

Source Link:

PAC1 receptor-mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain

Record Created:

Thursday, July 10, 2025 - 15:08

Schaler, A. W., Runyan, A. M., Clelland, C. L., Sydney, E. J., Fowler, S. L., Figueroa, H. Y., Shioda, S., Santa-Maria, I., Duff, K. E., & Myeku, N. (2021). PAC1 receptor–mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain. Science Translational Medicine, 13(595). https://doi.org/10.1126/scitranslmed.aba7394

Authors:

Ari W Schaler

Avery M Runyan

Catherine L Clelland

Eric J Sydney

Stephanie L Fowler

Helen Y Figueroa

Seiji Shioda

Ismael Santa-Maria

Karen E Duff

Natura Myeku

Affiliated Authors:

Ari W Schaler

Avery M Runyan

Catherine L Clelland

Eric J Sydney

Helen Y Figueroa

Ismael Santa-Maria

Karen E Duff

Natura Myeku

Columbia Affiliation:

Subjects:

Tauopathies (MeSH)

tau Proteins (MeSH)

Grants:

R01NS095922 (NIH – National Institute of Neurological Disorders and Stroke)

R01AG064244 (NIH – National Institute On Aging)

K01AG055694 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1126/scitranslmed.aba7394

PMID:

34039738

DOI:

10.1126/scitranslmed.aba7394

Journal:

Science Translational Medicine

Publication Date:

2021-05-28

Data Source:

PubMed

Source Link: