Carcinoma, Non-Small-Cell Lung

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Huang, H., Xu, Y., Guo, Z., Zhang, M., Li, W., Song, Y., Nie, J., Hu, W., Hei, T. K., & Zhou, G. (2025). Irradiation-responsive PRDM10-DT modulates the angiogenic response in human NSCLC cells in an SP1-dependent manner via the miR-663a/TGF-β1 axis. Journal of Translational Medicine, 23(1). https://doi.org/10.1186/s12967-025-06273-0
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Henick, B. S., Koch, P. D., Gainor, J. F., Awad, M. M., Chiuzan, C., Izard, S., Georgis, Y., Mallick, S., Garofano, R. F., Wong, C. V., Saqi, A., Grindheim, J., Schulze, K., Sonett, J. R., Rizvi, N. A., Izar, B., Taylor, A. M., & Shu, C. A. (2024). Neoadjuvant atezolizumab + chemotherapy for resectable NSCLC: 3-year clinical update of phase II clinical trial results and translational findings. Journal for ImmunoTherapy of Cancer, 12(12), e009301. https://doi.org/10.1136/jitc-2024-009301
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Faiena, I., Adhikary, S., Schweitzer, C., Astrow, S. H., Grogan, T., Funt, S. A., Bot, A., Dorff, T., Rosenberg, J. E., Elashoff, D. A., Pantuck, A. J., & Drakaki, A. (2024). Gene and Protein Expression of MAGE and Associated Immune Landscape Elements in Non–Small-Cell Lung Carcinoma and Urothelial Carcinomas. Journal of Immunotherapy. https://doi.org/10.1097/cji.0000000000000538
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Spira, A., Girard, N., Krebs, M., Park, K., Shu, C., Dougherty, L., & Cho, B. C. (2023). A plain language summary of the results from the group of patients in the CHRYSALIS study with EGFR exon 20 insertion-mutated non-small-cell lung cancer who received amivantamab. Future Oncology, 19(33), 2213–2225. https://doi.org/10.2217/fon-2023-0284
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Kinslow, C. J., ll, M. B., Cai, Y., Yan, J., Lorkiewicz, P. K., Al-Attar, A., Tan, J., Higashi, R. M., Lane, A. N., & Fan, T. W.-M. (2024). Stable isotope-resolved metabolomics analyses of metabolic phenotypes reveal variable glutamine metabolism in different patient-derived models of non-small cell lung cancer from a single patient. Metabolomics, 20(4). https://doi.org/10.1007/s11306-024-02126-x
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Saqi, A., Liu, Y., Politis, M. G., Salvatore, M., & Jambawalikar, S. (2024). Combined expert-in-the-loop—random forest multiclass segmentation U-net based artificial intelligence model: evaluation of non-small cell lung cancer in fibrotic and non-fibrotic microenvironments. Journal of Translational Medicine, 22(1). https://doi.org/10.1186/s12967-024-05394-2
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Wang, K., Du, R., Myall, N. J., Lewis, W. E., Uy, N., Hong, L., Skoulidis, F., Byers, L. A., Tsao, A., Cascone, T., Pozadzides, J., Tu, J., Negrao, M. V., Gibbons, D. L., Park, K., Rinsurongkawong, W., Lee, J. J., Gandara, D., Behl, D., … Le, X. (2024). Real-World Efficacy and Safety of Amivantamab for EGFR-Mutant NSCLC. Journal of Thoracic Oncology, 19(3), 500–506. https://doi.org/10.1016/j.jtho.2023.11.020
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Lin, C.-C., Garralda, E., Schöffski, P., Hong, D. S., Siu, L. L., Martin, M., Maur, M., Hui, R., Soo, R. A., Chiu, J., Zhang, T., Ma, B., Kyi, C., Tan, D. S., Cassier, P. A., Sarantopoulos, J., Weickhardt, A., Carvajal, R. D., Spratlin, J., … De Braud, F. (2023). A phase 2, multicenter, open-label study of anti-LAG-3 ieramilimab in combination with anti-PD-1 spartalizumab in patients with advanced solid malignancies. OncoImmunology, 13(1). https://doi.org/10.1080/2162402x.2023.2290787
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Altorki, N. K., Walsh, Z. H., Melms, J. C., Port, J. L., Lee, B. E., Nasar, A., Spinelli, C., Caprio, L., Rogava, M., Ho, P., Christos, P. J., Saxena, A., Elemento, O., Bhinder, B., Ager, C., Amin, A. D., Sanfilippo, N. J., Mittal, V., Borczuk, A. C., … McGraw, T. E. (2023). Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I–III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-44195-x
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Kinslow, C. J., Wang, Y., Liu, Y., Zuev, K. M., Chaudhary, K. R., Wang, T. J. C., Donalek, C., Amori, M., & Cheng, S. K. (2023). Influenza activity and regional mortality for non-small cell lung cancer. Scientific Reports, 13(1). https://doi.org/10.1038/s41598-023-47173-x
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González-Ruíz, J., A.Baccarelli, A., Cantu-de-Leon, D., & Prada, D. (2023). Air Pollution and Lung Cancer: Contributions of Extracellular Vesicles as Pathogenic Mechanisms and Clinical Utility. Current Environmental Health Reports, 10(4), 478–489. https://doi.org/10.1007/s40572-023-00421-8
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Dacic, S., Travis, W., Redman, M., Saqi, A., Cooper, W. A., Borczuk, A., Chung, J.-H., Glass, C., Lopez, J. M., Roden, A. C., Sholl, L., Weissferdt, A., Posadas, J., Walker, A., Zhu, H., Wijeratne, M. T., Connolly, C., Wynes, M., Bota-Rabassedas, N., … Wistuba, I. (2023). International Association for the Study of Lung Cancer Study of Reproducibility in Assessment of Pathologic Response in Resected Lung Cancers After Neoadjuvant Therapy. Journal of Thoracic Oncology, 18(10), 1290–1302. https://doi.org/10.1016/j.jtho.2023.07.017
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Rusthoven, C. G., Staley, A. W., Gao, D., Yomo, S., Bernhardt, D., Wandrey, N., El Shafie, R., Kraemer, A., Padilla, O., Chiang, V., Faramand, A. M., Palmer, J. D., Zacharia, B. E., Wegner, R. E., Hattangadi-Gluth, J. A., Levy, A., Bernstein, K., Mathieu, D., Cagney, D. N., … Yamamoto, M. (2023). Comparison of first-line radiosurgery for small-cell and non-small cell lung cancer brain metastases (CROSS-FIRE). JNCI: Journal of the National Cancer Institute, 115(8), 926–936. https://doi.org/10.1093/jnci/djad073
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Negrao, M. V., Araujo, H. A., Lamberti, G., Cooper, A. J., Akhave, N. S., Zhou, T., Delasos, L., Hicks, J. K., Aldea, M., Minuti, G., Hines, J., Aredo, J. V., Dennis, M. J., Chakrabarti, T., Scott, S. C., Bironzo, P., Scheffler, M., Christopoulos, P., Stenzinger, A., … Skoulidis, F. (2023). Comutations and KRASG12C Inhibitor Efficacy in Advanced NSCLC. Cancer Discovery, 13(7), 1556–1571. https://doi.org/10.1158/2159-8290.cd-22-1420
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DeBlasi, J. M., Falzone, A., Caldwell, S., Prieto-Farigua, N., Prigge, J. R., Schmidt, E. E., Chio, I. I. C., Karreth, F. A., & DeNicola, G. M. (2023). Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression. Cancer Research, 83(12), 1953–1967. https://doi.org/10.1158/0008-5472.can-22-3848
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Thummalapalli, R., Bernstein, E., Herzberg, B., Li, B. T., Iqbal, A., Preeshagul, I., Santini, F. C., Eng, J., Ladanyi, M., Yang, S.-R., Shen, R., Lito, P., Riely, G. J., Sabari, J. K., & Arbour, K. C. (2023). Clinical and Genomic Features of Response and Toxicity to Sotorasib in a Real-World Cohort of Patients With Advanced KRAS G12C-Mutant Non–Small Cell Lung Cancer. JCO Precision Oncology, 7. https://doi.org/10.1200/po.23.00030
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Dercle, L., Fronheiser, M., Rizvi, N. A., Hellmann, M. D., Maier, S., Hayes, W., Yang, H., Guo, P., Fojo, T., Schwartz, L. H., Zhao, B., & Leung, D. K. (2023). Baseline Radiomic Signature to Estimate Overall Survival in Patients With NSCLC. Journal of Thoracic Oncology, 18(5), 587–598. https://doi.org/10.1016/j.jtho.2022.12.019
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Ravi, A., Hellmann, M. D., Arniella, M. B., Holton, M., Freeman, S. S., Naranbhai, V., Stewart, C., Leshchiner, I., Kim, J., Akiyama, Y., Griffin, A. T., Vokes, N. I., Sakhi, M., Kamesan, V., Rizvi, H., Ricciuti, B., Forde, P. M., Anagnostou, V., Riess, J. W., … Gainor, J. F. (2023). Genomic and transcriptomic analysis of checkpoint blockade response in advanced non-small cell lung cancer. Nature Genetics, 55(5), 807–819. https://doi.org/10.1038/s41588-023-01355-5
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Kim, D.-W., Kim, S.-W., Camidge, D. R., Shu, C. A., Marrone, K. A., Le, X., Blakely, C. M., Park, K., Chang, G.-C., Patel, S. P., Kar, G., Cooper, Z. A., Samadani, R., Pluta, M., Kumar, R., & Ramalingam, S. (2023). CD73 Inhibitor Oleclumab Plus Osimertinib in Previously Treated Patients With Advanced T790M-Negative EGFR-Mutated NSCLC: A Brief Report. Journal of Thoracic Oncology, 18(5), 650–656. https://doi.org/10.1016/j.jtho.2022.12.021
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Pei, H., Dai, Y., Yu, Y., Tang, J., Cao, Z., Zhang, Y., Li, B., Nie, J., Hei, T. K., & Zhou, G. (2023). The Tumorigenic Effect of lncRNA AFAP1‐AS1 is Mediated by Translated Peptide ATMLP Under the Control of m6A Methylation. Advanced Science, 10(13). Portico. https://doi.org/10.1002/advs.202300314
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Park, K., Sabari, J. K., Haura, E. B., Shu, C. A., Spira, A., Salgia, R., Reckamp, K. L., Sanborn, R. E., Govindan, R., Bauml, J. M., Curtin, J. C., Xie, J., Roshak, A., Lorenzini, P., Millington, D., Thayu, M., Knoblauch, R. E., & Cho, B. C. (2023). Management of infusion-related reactions (IRRs) in patients receiving amivantamab in the CHRYSALIS study. Lung Cancer, 178, 166–171. https://doi.org/10.1016/j.lungcan.2023.02.008
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Lee, S. M., Fan, W., Wang, A., Vaidya, R., Redman, M. W., Gettinger, S. N., Bazhenova, L., Herbst, R. S., Hershman, D. L., & Unger, J. M. (2023). Novel Approaches for Dynamic Visualization of Adverse Event Data in Oncology Clinical Trials: A Case Study Using Immunotherapy Trial S1400-I (SWOG). JCO Clinical Cancer Informatics, 7. https://doi.org/10.1200/cci.22.00165
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Steinfort, D. P., Antippa, P., Rangamuwa, K., Irving, L. B., Christie, M., Chan, E., Marinelli, B., Wang, J., Yoneda, K. Y., Raina, S., & Herth, F. J. (2023). Safety and Feasibility of a Novel Externally Cooled Bronchoscopic Radiofrequency Ablation Catheter for Ablation of Peripheral Lung Tumours: A First-In-Human Dose Escalation Study. Respiration, 102(3), 211–219. Portico. https://doi.org/10.1159/000529167
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Maniar, R., Gallitano, S. M., Husain, S., Moazami, G., Weiss, M. J., & Shu, C. A. (2023). Unusual Adverse Events in a Patient With BRAF-Mutated Non–Small Cell Lung Cancer Treated With BRAF/MEK Inhibition. Journal of the National Comprehensive Cancer Network, 21(3), 232–234. https://doi.org/10.6004/jnccn.2022.7084
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Maniar, R., Wang, P. H., Washburn, R. S., Kratchmarov, R., Coley, S. M., Saqi, A., Pan, S. S., Hu, J., Shu, C. A., Rizvi, N. A., Henick, B. S., & Reiner, S. L. (2022). Self-Renewing CD8+ T-cell Abundance in Blood Associates with Response to Immunotherapy. Cancer Immunology Research, 11(2), 164–170. https://doi.org/10.1158/2326-6066.cir-22-0524
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Pan, Y., Han, H., Hu, H., Wang, H., Song, Y., Hao, Y., Tong, X., Patel, A. S., Misirlioglu, S., Tang, S., Huang, H.-Y., Geng, K., Chen, T., Karatza, A., Sherman, F., Labbe, K. E., Yang, F., Chafitz, A., Peng, C., … Wong, K.-K. (2023). KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition. Cancer Cell, 41(1), 88-105.e8. https://doi.org/10.1016/j.ccell.2022.11.015
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Savari, O., Febres‐Aldana, C., Chang, J. C., Fanaroff, R. E., Ventura, K., Bodd, F., Paik, P., Vundavalli, M., Saqi, A., Askin, F. B., Travis, W. D., & Rekhtman, N. (2022). Non‐small cell lung carcinomas with diffuse coexpression of TTF1 and p40: clinicopathological and genomic features of 14 rare biphenotypic tumours. Histopathology, 82(2), 242–253. Portico. https://doi.org/10.1111/his.14801
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de Castro, G., Rizvi, N. A., Schmid, P., Syrigos, K., Martin, C., Yamamoto, N., Cheng, Y., Moiseyenko, V., Summers, Y., Vynnychenko, I., Lee, S. Y., Bryl, M., Zer, A., Erman, M., Timcheva, C., Raja, R., Naicker, K., Scheuring, U., Walker, J., … Mok, T. (2023). NEPTUNE: Phase 3 Study of First-Line Durvalumab Plus Tremelimumab in Patients With Metastatic NSCLC. Journal of Thoracic Oncology, 18(1), 106–119. https://doi.org/10.1016/j.jtho.2022.09.223
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Capaccione, K. M., Huang, S., D’souza, B., Leb, J., Luk, L., Goldstein, J., May, B., Deng, A., & Salvatore, M. M. (2023). Radiographic features of pneumonitis in patients treated with immunotherapy compared to traditional chemotherapy for non-small cell lung cancer. Clinical Imaging, 93, 106–112. https://doi.org/10.1016/j.clinimag.2022.03.006
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Primakov, S. P., Ibrahim, A., van Timmeren, J. E., Wu, G., Keek, S. A., Beuque, M., Granzier, R. W. Y., Lavrova, E., Scrivener, M., Sanduleanu, S., Kayan, E., Halilaj, I., Lenaers, A., Wu, J., Monshouwer, R., Geets, X., Gietema, H. A., Hendriks, L. E. L., Morin, O., … Lambin, P. (2022). Automated detection and segmentation of non-small cell lung cancer computed tomography images. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-30841-3
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Chaudhary, K. R., Kinslow, C. J., Cheng, H., Silva, J. M., Yu, J., Wang, Tony. J., Hei, T. K., Halmos, B., & Cheng, S. K. (2022). Smurf2 inhibition enhances chemotherapy and radiation sensitivity in non-small-cell lung cancer. Scientific Reports, 12(1). https://doi.org/10.1038/s41598-022-14448-8
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Van Egeren, D., Kohli, K., Warner, J. L., Bedard, P. L., Riely, G., Lepisto, E., Schrag, D., LeNoue-Newton, M., Catalano, P., Kehl, K. L., Michor, F., Fiandalo, M., Foti, M., Khotskaya, Y., Lee, J., Peters, N., Sweeney, S., Abraham, J., … Walther, Z. (2022). Genomic analysis of early-stage lung cancer reveals a role for TP53 mutations in distant metastasis. Scientific Reports, 12(1). https://doi.org/10.1038/s41598-022-21448-1
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Ricciuti, B., Wang, X., Alessi, J. V., Rizvi, H., Mahadevan, N. R., Li, Y. Y., Polio, A., Lindsay, J., Umeton, R., Sinha, R., Vokes, N. I., Recondo, G., Lamberti, G., Lawrence, M., Vaz, V. R., Leonardi, G. C., Plodkowski, A. J., Gupta, H., Cherniack, A. D., … Awad, M. M. (2022). Association of High Tumor Mutation Burden in Non–Small Cell Lung Cancers With Increased Immune Infiltration and Improved Clinical Outcomes of PD-L1 Blockade Across PD-L1 Expression Levels. JAMA Oncology, 8(8), 1160. https://doi.org/10.1001/jamaoncol.2022.1981
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Bailey, S., Wang, Q., Kong, C. Y., Stone, K., Veluswamy, R., Bates, S. E., Smith, C. B., Wisnivesky, J. P., & Sigel, K. (2022). Optimizing the use of adjuvant chemotherapy in non-small cell lung cancer patients with comorbidities. Current Problems in Cancer, 46(4), 100867. https://doi.org/10.1016/j.currproblcancer.2022.100867
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Henick, B. S., Villarroel-Espindola, F., Datar, I., Sanmamed, M. F., Yu, J., Desai, S., Li, A., Aguirre-Ducler, A., Syrigos, K., Rimm, D. L., Chen, L., Herbst, R. S., & Schalper, K. A. (2022). Quantitative tissue analysis and role of myeloid cells in non-small cell lung cancer. Journal for ImmunoTherapy of Cancer, 10(7), e005025. https://doi.org/10.1136/jitc-2022-005025
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Govindan, R., Aggarwal, C., Antonia, S. J., Davies, M., Dubinett, S. M., Ferris, A., Forde, P. M., Garon, E. B., Goldberg, S. B., Hassan, R., Hellmann, M. D., Hirsch, F. R., Johnson, M. L., Malik, S., Morgensztern, D., Neal, J. W., Patel, J. D., Rimm, D. L., Sagorsky, S., … Herbst, R. S. (2022). Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of lung cancer and mesothelioma. Journal for ImmunoTherapy of Cancer, 10(5), e003956. https://doi.org/10.1136/jitc-2021-003956
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Biswas, A. K., Han, S., Tai, Y., Ma, W., Coker, C., Quinn, S. A., Shakri, A. R., Zhong, T. J., Scholze, H., Lagos, G. G., Mela, A., Manova-Todorova, K., de Stanchina, E., Ferrando, A. A., Mendelsohn, C., Canoll, P., Yu, H. A., Paik, P. K., Saqi, A., … Acharyya, S. (2022). Targeting S100A9–ALDH1A1–Retinoic Acid Signaling to Suppress Brain Relapse inEGFR-Mutant Lung Cancer. Cancer Discovery, 12(4), 1002–1021. https://doi.org/10.1158/2159-8290.cd-21-0910
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Wang, F., Liu, Y., Qiu, W., Shum, E., Feng, M., Zhao, D., Zheng, D., Borczuk, A., Cheng, H., & Halmos, B. (2022). Functional Analysis of MET Exon 14 Skipping Alteration in Cancer Invasion and Metastatic Dissemination. Cancer Research, 82(7), 1365–1379. https://doi.org/10.1158/0008-5472.can-21-1327
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