KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition

Pan, Y., Han, H., Hu, H., Wang, H., Song, Y., Hao, Y., Tong, X., Patel, A. S., Misirlioglu, S., Tang, S., Huang, H.-Y., Geng, K., Chen, T., Karatza, A., Sherman, F., Labbe, K. E., Yang, F., Chafitz, A., Peng, C., … Wong, K.-K. (2023). KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition. Cancer Cell, 41(1), 88-105.e8. https://doi.org/10.1016/j.ccell.2022.11.015
Authors:
Yuanwang Pan
Han Han
Hai Hu
Hua Wang
Yueqiang Song
Yuan Hao
Xinyuan Tong
Ayushi S Patel
Selim Misirlioglu
Sittinon Tang
Hsin-Yi Huang
Ke Geng
Ting Chen
Angeliki Karatza
Fiona Sherman
Kristen E Labbe
Fan Yang
Alison Chafitz
Chengwei Peng
Chenchen Guo
Andre L Moreira
Vamsidhar Velcheti
Sally C M Lau
Pengfei Sui
Haiquan Chen
J Alan Diehl
Anil K Rustgi
Adam J Bass
John T Poirier
Xiaoyang Zhang
Hongbin Ji
Hua Zhang
Kwok-Kin Wong
Affiliated Authors:
Anil K Rustgi
Adam J Bass
Columbia Affiliation:
Subjects:
Carcinoma, Non-Small-Cell Lung (MeSH)
Carcinoma, Squamous Cell (MeSH)
Lung Neoplasms (MeSH)
Author Keywords:
egfr
erbb2
kmt2d
lung squamous cell carcinoma
organoids
shp2
elink
Publication Type:
Article
Unique ID:
10.1016/j.ccell.2022.11.015
PMID:
36525973
DOI:
10.1016/j.ccell.2022.11.015
Journal:
Cancer Cell
Publication Date:
Data Source:
PubMed
Source Link:
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Record Created: