Multiplex base editing to protect from CD33 directed drugs for immune and gene therapy

Borot, F., Humbert, O., Ehmsen, J. T., Fields, E., Kohli, S., Radtke, S., Swing, K., Pande, D., Enstrom, M. R., Laszlo, G. S., Mayuranathan, T., Ali, A. M., Weiss, M. J., Yen, J. S., Newby, G. A., Walter, R. B., Liu, D. R., Mukherjee, S., & Kiem, H.-P. (2025). Multiplex base editing to protect from CD33 directed drugs for immune and gene therapy. Nature Communications, 16(1). https://doi.org/10.1038/s41467-025-59713-2

Authors:

Florence Borot

Olivier Humbert

Jeffrey T Ehmsen

Emily Fields

Sajeev Kohli

Stefan Radtke

Kyle Swing

Dnyanada Pande

Mark R Enstrom

George S Laszlo

Thiyagaraj Mayuranathan

Abdullah Mahmood Ali

Mitchell J Weiss

Jonathan S Yen

Gregory A Newby

Roland B Walter

David R Liu

Siddhartha Mukherjee

Hans-Peter Kiem

Affiliated Authors:

Florence Borot

Abdullah Mahmood Ali

Siddhartha Mukherjee

Columbia Affiliation:

Vagelos College of Physicians and Surgeons
- Department of Medicine
  Division of Hematology/Oncology

Subjects:

Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated proteins (OpenAlex Topic)

Epidemiology and Management of Cytomegalovirus Infection (OpenAlex Topic)

Gene Therapy Techniques and Applications (OpenAlex Topic)

Gene Editing (MeSH)

Sialic Acid Binding Ig-like Lectin 3 (MeSH)

Genetic Therapy (MeSH)

Immunotherapy (MeSH)

Publication Type:

Article

Unique ID:

10.1038/s41467-025-59713-2

PMID:

DOI:

10.1038/s41467-025-59713-2

Journal:

Nature Communications

Publication Date:

2025-05-28

Data Source:

PubMed

Source Link:

View PubMed Record

View OpenAlex Record

View Web of Science Record

Record Created:

Tuesday, June 3, 2025 - 08:59