Nurr1/CoREST Pathway in Neuroprotection and Inflammation

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Johansson, E., Freuchet, A., Williams, G. P., Michealis, T., Frazier, A., Litvan, I., Goldman, J. G., Alcalay, R. N., Standaert, D. G., Amara, A. W., Stover, N., Fon, E. A., Postuma, R. B., Sidney, J., Sulzer, D., Lindestam Arlehamn, C. S., & Sette, A. (2025). T cell responses towards PINK1 and α-synuclein are elevated in prodromal Parkinson’s disease. Npj Parkinson’s Disease, 11(1). https://doi.org/10.1038/s41531-025-01001-3
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Freuchet, A., Johansson, E., Frazier, A., Litvan, I., Goldman, J. G., Alcalay, R. N., Sulzer, D., Lindestam Arlehamn, C. S., & Sette, A. (2025). Differential memory enrichment of cytotoxic CD4 T cells in Parkinson’s disease patients reactive to α-synuclein. Npj Parkinson’s Disease, 11(1). https://doi.org/10.1038/s41531-025-00981-6
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Williams, G. P., Freuchet, A., Michaelis, T., Frazier, A., Tran, N. K., Rodrigues Lima-Junior, J., Phillips, E. J., Mallal, S. A., Litvan, I., Goldman, J. G., Alcalay, R. N., Sidney, J., Sulzer, D., Sette, A., & Lindestam Arlehamn, C. S. (2024). PINK1 is a target of T cell responses in Parkinson’s disease. Journal of Clinical Investigation. https://doi.org/10.1172/jci180478
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Arain, H. A., Idiarte, J. F., Lama, T. D., Figueroa, H. Y., Guo, J., Duff, K. E., & Nuriel, T. (2024). APOE4 Alters Tau Propagation in Regions Associated with Early Alzheimer’s Disease in a Humanized Mouse Model of Tau Spread. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.089837
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Collins, C. A., Waller, C., Batourina, E., Kumar, L., Mendelsohn, C. L., & Gilbert, N. M. (2024). Nur77 protects the bladder urothelium from intracellular bacterial infection. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-52454-8
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Tayran, H., Yilmaz, E., Bhattarai, P., Min, Y., Wang, X., Ma, Y., Wang, N., Jeong, I., Nelson, N., Kassara, N., Cosacak, M. I., Dogru, R. M., Reyes-Dumeyer, D., Stenersen, J. M., Reddy, J. S., Qiao, M., Flaherty, D., Gunasekaran, T. I., Yang, Z., … Kizil, C. (2024). ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimer’s disease through BDNF/NGFR signaling. Cell Genomics, 4(9), 100642. https://doi.org/10.1016/j.xgen.2024.100642
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Chia, R., Ray, A., Shah, Z., Ding, J., Ruffo, P., Fujita, M., Menon, V., Saez-Atienzar, S., Reho, P., Kaivola, K., Walton, R. L., Reynolds, R. H., Karra, R., Sait, S., Akcimen, F., Diez-Fairen, M., Alvarez, I., Fanciulli, A., Stefanova, N., … Scholz, S. W. (2024). Genome sequence analyses identify novel risk loci for multiple system atrophy. Neuron, 112(13), 2142-2156.e5. https://doi.org/10.1016/j.neuron.2024.04.002
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Wang, Y., Tinsley, B., Spolitu, S., Zadroga, J. A., Agarwal, H., Sarecha, A. K., & Ozcan, L. (2024). Geranylgeranyl isoprenoids and hepatic Rap1a regulate basal and statin-induced expression of PCSK9. Journal of Lipid Research, 65(3), 100515. https://doi.org/10.1016/j.jlr.2024.100515
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Dhanwani, R., Lima-Junior, J. R., Sethi, A., Pham, J., Williams, G., Frazier, A., Xu, Y., Amara, A. W., Standaert, D. G., Goldman, J. G., Litvan, I., Alcalay, R. N., Peters, B., Sulzer, D., Arlehamn, C. S. L., & Sette, A. (2022). Transcriptional analysis of peripheral memory T cells reveals Parkinson’s disease-specific gene signatures. Npj Parkinson’s Disease, 8(1). https://doi.org/10.1038/s41531-022-00282-2
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Basseville, A., Violet, P.-C., Safari, M., Sourbier, C., Linehan, W. M., Robey, R. W., Levine, M., Sackett, D. L., & Bates, S. E. (2022). A Histone Deacetylase Inhibitor Induces Acetyl-CoA Depletion Leading to Lethal Metabolic Stress in RAS-Pathway Activated Cells. Cancers, 14(11), 2643. https://doi.org/10.3390/cancers14112643
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Davis, E. J., Solsberg, C. W., White, C. C., Miñones-Moyano, E., Sirota, M., Chibnik, L., Bennett, D. A., De Jager, P. L., Yokoyama, J. S., & Dubal, D. B. (2021). Sex-Specific Association of the X Chromosome With Cognitive Change and Tau Pathology in Aging and Alzheimer Disease. JAMA Neurology, 78(10), 1249. https://doi.org/10.1001/jamaneurol.2021.2806
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