Protein-Tyrosine Kinases

Displaying 1 - 3 of 3CSV
Syphers, J. L., Wright, J. A., Liu, S., Gee, Y. S., Gao, F., Mudududdla, R., Che, D. Q., Chang, A., Sloan, E. K., Narasimhan, V., Heriot, A., Ramsay, R. G., de Nys, R., Silva, T. N., Vrbanac, L., Sammour, T., Lawrence, M. J., Tin, T., Maddern, G. J., … Baell, J. B. (2025). Discovery of WEE1 Kinase Inhibitors with Potent Activity against Patient-Derived, Metastatic Colorectal Cancer Organoids. Journal of Medicinal Chemistry, 68(8), 8065–8090. https://doi.org/10.1021/acs.jmedchem.4c02541
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Yaron-Barir, T. M., Joughin, B. A., Huntsman, E. M., Kerelsky, A., Cizin, D. M., Cohen, B. M., Regev, A., Song, J., Vasan, N., Lin, T.-Y., Orozco, J. M., Schoenherr, C., Sagum, C., Bedford, M. T., Wynn, R. M., Tso, S.-C., Chuang, D. T., Li, L., Li, S. S.-C., … Johnson, J. L. (2024). The intrinsic substrate specificity of the human tyrosine kinome. Nature, 629(8014), 1174–1181. https://doi.org/10.1038/s41586-024-07407-y
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Bhat, N., Narayanan, A., Fathzadeh, M., Kahn, M., Zhang, D., Goedeke, L., Neogi, A., Cardone, R. L., Kibbey, R. G., Fernandez-Hernando, C., Ginsberg, H. N., Jain, D., Shulman, G. I., & Mani, A. (2022). Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice. Journal of Clinical Investigation, 132(3). https://doi.org/10.1172/jci153724
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