Journal for ImmunoTherapy of Cancer
Displaying 1 - 43 of 43
Paiola, M., Portnoy, D. M., Hao, L. Y., Bukhari, S., Winchester, R. J., Henick, B. S., Mor, A., & Gartshteyn, Y. (2025). Osteoarthritis increases the risk of inflammatory arthritis due to immune checkpoint inhibitors associated with tissue-resident memory T cells. Journal for ImmunoTherapy of Cancer, 13(3), e010758. https://doi.org/10.1136/jitc-2024-010758
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Henick, B. S., Koch, P. D., Gainor, J. F., Awad, M. M., Chiuzan, C., Izard, S., Georgis, Y., Mallick, S., Garofano, R. F., Wong, C. V., Saqi, A., Grindheim, J., Schulze, K., Sonett, J. R., Rizvi, N. A., Izar, B., Taylor, A. M., & Shu, C. A. (2024). Neoadjuvant atezolizumab + chemotherapy for resectable NSCLC: 3-year clinical update of phase II clinical trial results and translational findings. Journal for ImmunoTherapy of Cancer, 12(12), e009301. https://doi.org/10.1136/jitc-2024-009301
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Maynard, R., Fitzgerald, A., Nasir, A., Eisman, S. E., Jablonski, S. A., Pearson, G., Mace, E., & Weiner, L. M. (2024). 1123 Promoting immune cell tumor invasion through forced overexpression of proteases. Regular and Young Investigator Award Abstracts, A1245–A1245. https://doi.org/10.1136/jitc-2024-sitc2024.1123
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Saenger, Y., Zhang, C., Espinoza, G., Bracero, Y., Kenchappa, D., Moon, J.-Y., Matteo, A., Bioh, L., Sultana, S., Singh, A., Aung, T., Gartrell, R. D., Leung, L., Ferringer, T., Chang, R., Horst, B., Nastiuk, K., Rimm, D., & Geskin, L. (2024). 127 Digital pathology prognostic biomarkers- time for clinical application in melanoma. Regular and Young Investigator Award Abstracts, A140–A141. https://doi.org/10.1136/jitc-2024-sitc2024.0127
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Schoenfeld, A. J., Izar, B., Spira, A., Zamarin, D., Spigel, D. R., Hoimes, C., McDermott, D. F., Sehgal, K., Najjar, Y. G., Garon, E. B., Sullivan, R. J., Henick, B., Leal, T. A., Hurwitz, M., McKay, R., Gong, X., Rokade, S., Stager, A. M., Bach, K., … Oft, M. (2024). 1325 T cell and immune activation from a phase 1 study of STK-012, a first-in-class IL-2R α/β selective partial agonist in advanced solid tumors. Regular and Young Investigator Award Abstracts, A1484–A1484. https://doi.org/10.1136/jitc-2024-sitc2024.1325
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Mallick, S., Henick, B., Georgis, Y., Zhakula, N., Concepcion-Crisol, C., Herzberg, B., & Taylor, A. (2024). 1365 Chromosome 19p status associates with clinical outcomes in a histology-dependent manner in non-small cell lung cancer. Regular and Young Investigator Award Abstracts, A1529–A1529. https://doi.org/10.1136/jitc-2024-sitc2024.1365
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Sommerhalder, D., Demel, K., Noel, M. S., Emamekhoo, H., Peguero, J., Balaraman, R., Moy, R. H., Scheuber, A., Haas, J., Chabas, D., Kumar, P., Daigle, S. R., Dasen, S., Zhang, X., Gutierrez, M., Sharma, S., & Hussain, A. (2024). 682 Ongoing phase 1/2 trial of the HPK1 inhibitor NDI-101150 as monotherapy and in combination with pembrolizumab: clinical safety update and renal cell carcinoma (RCC) efficacy analysis. Regular and Young Investigator Award Abstracts, A782–A783. https://doi.org/10.1136/jitc-2024-sitc2024.0682
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Davar, D., Williams, A., Lopez, J., Olson, D., Sato, T., Shaw, H., Friedman, C. F., Thistlethwaite, F., Middleton, M., Lebbe, C., Ma, V. T., Izar, B., Lau, P., Bechter, O., Kirk, P., Yuan, Y., Marshall, S., & Hamid, O. (2024). 694 Phase 1 safety and efficacy of brenetafusp, a PRAME × CD3 ImmTAC bispecific, in post-checkpoint cutaneous melanoma (CM). Regular and Young Investigator Award Abstracts, A796–A796. https://doi.org/10.1136/jitc-2024-sitc2024.0694
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Sharma, M. R., Johnson, M. L., Puzanov, I., Sznol, M., Mckean, M., Gainor, J. F., Spira, A., Henick, B., Tolcher, A. W., Chen, C. T., El-Khoueiry, A., Broderick, J., Peng, L., Che, J., Cao, L., Wilson, D., Lathers, D., Horak, C., Feltquate, D., & Luke, J. J. (2024). 758 GLIMMER-01: phase 1/2 trial of a first-in-class bi-sialidase (E-602) in combination with cemiplimab in patients with PD-(L)1-resistant solid tumors. Regular and Young Investigator Award Abstracts, A862–A862. https://doi.org/10.1136/jitc-2024-sitc2024.0758
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Ager, C. R., Jugler, C., Zhu, Y., Chen, D., Athar, M., Izar, B., Bickers, D., & Kim, A. (2024). 791 Immunological correlates of response to vismodegib and PD-1 blockade in an autochthonous model of basal cell nevus (Gorlin-Goltz) syndrome. Regular and Young Investigator Award Abstracts, A896–A896. https://doi.org/10.1136/jitc-2024-sitc2024.0791
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Daigle, S. R., Elliott, G., Boiko, S., Sommerhalder, D., Noel, M. S., Sharma, S., Balaraman, R., Gutierrez, M., Demel, K., Moy, R. H., Ciccone, D., Zhang, X., Scheuber, A., & Kumar, P. (2024). 83 Tumor immune microenvironment characterization from pre- and post-dose tumors collected from a phase 1/2 study of NDI-101150, a hematopoietic progenitor kinase 1 (HPK1) inhibitor. Regular and Young Investigator Award Abstracts, A91–A91. https://doi.org/10.1136/jitc-2024-sitc2024.0083
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Iwamoto, F., Rotolo, J. A., Abbate, F., Scuoppo, C., Levrero, C., Buerki, R. a, Dalahmah, O. A., & Haras, A. V. (2024). 991 ST101, an inhibitor of the transcription factor C/EBPß, promotes an immune-active tumor microenvironment in a window of opportunity (WoO) study of patients with glioblastoma (GBM). Regular and Young Investigator Award Abstracts, A1111–A1112. https://doi.org/10.1136/jitc-2024-sitc2024.0991
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Atkins, M. B., Jegede, O. A., Haas, N. B., Mcdermott, D. F., Bilen, M. A., Stein, M., Sosman, J., Alter, R., Plimack, E. R., Ornstein, M. C., Hurwitz, M., Peace, D. J., Einstein, D., Catalano, P. J., Hammers, H., & Regan, M. M. (2024). Treatment-free survival outcomes from the phase II study of nivolumab and salvage nivolumab/ipilimumab in advanced clear cell renal cell carcinoma (HCRN GU16-260-Cohort A). Journal for ImmunoTherapy of Cancer, 12(4), e008293. https://doi.org/10.1136/jitc-2023-008293
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Hu, X., Bukhari, S. M., Tymm, C., Adam, K., Lerrer, S., Henick, B. S., Winchester, R. J., & Mor, A. (2024). Inhibition of IL-25/IL-17RA improves immune-related adverse events of checkpoint inhibitors and reveals antitumor activity. Journal for ImmunoTherapy of Cancer, 12(3), e008482. https://doi.org/10.1136/jitc-2023-008482
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Daugherty, B. L., Boohaker, R. J., Johnstone, R., Stinson, K., Zhao, G., Zang, M., Qian, J., Wang, T. C., & Lederman, S. (2023). 1345 mTFF2-MSA (mTNX-1700) suppresses tumor growth and increases survival in anti-PD-1 treated CT26.wt subcutaneous and CT26-Luciferase orthotopic syngeneic colorectal cancer models by targeting MDSCs. Regular and Young Investigator Award Abstracts. https://doi.org/10.1136/jitc-2023-sitc2023.1345
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Ventin, M., Cattaneo, G., Jia, J., Arya, S., Maggs, L., Sun, Y., Boland, G. M., Jenkins, R. W., Ksander, B. R., Haq, R., Wang, X., Ryeom, S., Ferrone, C. R., & Ferrone, S. (2023). 317 B7-H3-targeted CAR T cell with an inducible caspase 9 suicide gene effectively eradicates uveal melanoma liver metastases. Regular and Young Investigator Award Abstracts. https://doi.org/10.1136/jitc-2023-sitc2023.0317
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Qian, J., Ryeom, S., Daugherty, B. L., Lederman, S., & Wang, T. C. (2023). 481 A CXCR4 partial agonist TFF2-MSA sensitized advanced gastric cancer to PD-1 blockade by systematically reducing PMN-MDSC accumulation, immunosuppression, and generation in bone marrow. Regular and Young Investigator Award Abstracts. https://doi.org/10.1136/jitc-2023-sitc2023.0481
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Minns, H., Padilla, O., Wei, H.-J., Gartrell, R. D., Webster-Carrion, A., Tazhibi, M., McQuillan, N., Zhang, X., Gallitto, M., Yeh, R., Zhang, Z., Hei, T., Szalontay, L., Pavisic, J., Garty, G., Garvin, J., Canoll, P., Vanpouille-Box, C., Menon, V., … Wu, C.-C. (2023). 53 Inducing immune response with FLASH and conventional radiation in diffuse midline glioma (DMG). Regular and Young Investigator Award Abstracts. https://doi.org/10.1136/jitc-2023-sitc2023.0053
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Stein, M. N., Hawley, J., Zibelman, M., Pachynski, R., Dreicer, R., Zarrabi, K. K., Miles, B., Hauke, R. J., Marshall, M. A., Jones, B., Wheeler, V., Sebastian, S., Anderson, K., Vardeu, A., Davis, C., Bendall, J., & Shore, N. (2023). 665 Immunotherapeutic trial in men with biochemical recurrence after definitive local therapy for prostate cancer: A clinical trial in progress. Regular and Young Investigator Award Abstracts. https://doi.org/10.1136/jitc-2023-sitc2023.0665
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Malki, M. A., Keyzner, A., Suh, H. C., Matin, A., Buonomo, E., Wang, Y., Abelowitz, N., Murray, J., MacBeath, G., Barton, D., Chattopadhyay, S., & Reshef, R. (2023). 682 Trial in progress: phase 1 trial of TSC-100 and TSC-101, engineered T-cell therapies targeting minor histocompatibility antigens to eliminate residual disease after hematopoietic cell transplantation. Regular and Young Investigator Award Abstracts. https://doi.org/10.1136/jitc-2023-sitc2023.0682
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Bupathi, M., Wang, J. S., Hu-Lieskovan, S., Piha-Paul, S. A., Chmielowski, B., Garmezy, B., Najjar, Y. G., Stein, M. N., Yao, L., Kanodia, J., Clynes, R., McGovern, P., & Thompson, B. (2023). 764 A phase 1, first-in-human (FIH), open-label, dose-finding and expansion study of XmAb808, a B7H3 x CD28 bispecific antibody, in combination with pembrolizumab in patients with advanced solid tumors. Regular and Young Investigator Award Abstracts. https://doi.org/10.1136/jitc-2023-sitc2023.0764
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Migden, M. R., Chai-Ho, W., Daniels, G. A., Wise-Draper, T. M., Kheterpal, M., Tang, J. C., Bolotin, D., Verschraegen, C., Poklepovic, A. S., Khan, S. A., Ibrahim, S. F., Zeitouni, N. C., Medina, T., Tsai, K. K., Tucci, C., Navia, S., Donthireddy, L., Bommareddy, P. K., Hou, J. W., & Davar, D. (2023). 777 Initial results from an open-label phase 1b/2 study of RP1 oncolytic immunotherapy in solid organ and hematopoietic cell transplant recipients with advanced cutaneous malignancies (ARTACUS). Regular and Young Investigator Award Abstracts. https://doi.org/10.1136/jitc-2023-sitc2023.0777
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Patel, S. P., Carvajal, R., Montazeri, K., Reddy, S., Lutzky, J., Khan, S. A., Chmielowski, B., Bhatia, S., Medina, T., Haymaker, C., Sheth, R., Kuban, J. D., Thornton, L., Wehrenberg-Klee, E., Novelli, P., Lucci, A., Sarli, V., Meas, S., Cox, B., … Davar, D. (2023). 1534 Clinical activity of SD-101 with immune checkpoint inhibition (ICI) in metastatic uveal melanoma liver metastasis (MUM-LM) from the PERIO-01 Phase 1 trial. Late-Breaking Abstracts. https://doi.org/10.1136/jitc-2023-sitc2023.1534
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Pavlick, A. C., Ariyan, C. E., Buchbinder, E. I., Davar, D., Gibney, G. T., Hamid, O., Hieken, T. J., Izar, B., Johnson, D. B., Kulkarni, R. P., Luke, J. J., Mitchell, T. C., Mooradian, M. J., Rubin, K. M., Salama, A. K., Shirai, K., Taube, J. M., Tawbi, H. A., Tolley, J. K., … Sullivan, R. J. (2023). Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of melanoma, version 3.0. Journal for ImmunoTherapy of Cancer, 11(10), e006947. https://doi.org/10.1136/jitc-2023-006947
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Ager, C. R., Zhang, M., Chaimowitz, M., Bansal, S., Tagore, S., Obradovic, A., Jugler, C., Rogava, M., Melms, J. C., McCann, P., Spina, C., Drake, C. G., Dallos, M. C., & Izar, B. (2023). KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response. Journal for ImmunoTherapy of Cancer, 11(9), e006782. https://doi.org/10.1136/jitc-2023-006782
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Vagelos College of Physicians and Surgeons; Department of Molecular Pharmacology and Therapeutics; Department of Radiation Oncology; Department of Systems Biology; Department of Biochemistry and Molecular Biophysics; Department of Biomedical Informatics; Department of Medicine; Division of Hematology/Oncology; Department of Urology; Center for Translational Immunology; Herbert Irving Comprehensive Cancer Center
Siddiqui, B. A., Chapin, B. F., Jindal, S., Duan, F., Basu, S., Yadav, S. S., Gu, A.-D., Espejo, A. B., Kinder, M., Pettaway, C. A., Ward, J. F., Tidwell, R. S. S., Troncoso, P., Corn, P. G., Logothetis, C. J., Knoblauch, R., Hutnick, N., Gottardis, M., Drake, C. G., … Subudhi, S. K. (2023). Immune and pathologic responses in patients with localized prostate cancer who received daratumumab (anti-CD38) or edicotinib (CSF-1R inhibitor). Journal for ImmunoTherapy of Cancer, 11(3), e006262. https://doi.org/10.1136/jitc-2022-006262
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Joshi, M., Tuanquin, L., Zhu, J., Walter, V., Schell, T., Kaag, M., Kilari, D., Liao, J., Holder, S. L., Emamekhoo, H., Sankin, A., Merrill, S., Zheng, H., Warrick, J., Hauke, R., Gartrel, B., Stein, M., Drabick, J., Degraff, D. J., & Zakharia, Y. (2023). Concurrent durvalumab and radiation therapy (DUART) followed by adjuvant durvalumab in patients with localized urothelial cancer of bladder: results from phase II study, BTCRC-GU15-023. Journal for ImmunoTherapy of Cancer, 11(2), e006551. https://doi.org/10.1136/jitc-2022-006551
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Tanagala, K. K. K., Morin-Baxter, J., Carvajal, R., Cheema, M., Dubey, S., Nakagawa, H., Yoon, A., Cheng, Y.-S. L., Taylor, A., Nickerson, J., Mintz, A., & Momen-Heravi, F. (2022). SP140 inhibits STAT1 signaling, induces IFN-γ in tumor-associated macrophages, and is a predictive biomarker of immunotherapy response. Journal for ImmunoTherapy of Cancer, 10(12), e005088. https://doi.org/10.1136/jitc-2022-005088
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Vagelos College of Physicians and Surgeons; Department of Pathology and Cell Biology; Department of Medicine; Division of Digestive and Liver Diseases; Herbert Irving Comprehensive Cancer Center; Department of Radiology; College of Dental Medicine; Section of Oral, Diagnostic, and Rehabilitation Sciences
Gupta, P., Dang, M., Hao, D., Bojja, K., Tran, T., Shehwana, H., Kamiya-Matsuoka, C., Li, J., Audia, A., Kassab, C., Ott, M., Gumin, J., Alenazy, S., Goldman, A., Seth, S., Maheshwari, A., Balasubramaniyan, V., Vaillant, B., Groot, J. de, … Bhat, K. (2022). 1001 Immunophenotyping of brain tumors identifies interferon enriched phagocytes in human gliomas. Regular and Young Investigator Award Abstracts, A1043–A1043. https://doi.org/10.1136/jitc-2022-sitc2022.1001
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Maynard, R., Fitzgerald, A., Nasir, A., Glasgow, E., Jablonski, S., Veken, P. V. D., Pearson, G., Mace, E., & Weiner, L. (2022). 1012 Fibroblast activation protein regulates human natural killer cell migration. Regular and Young Investigator Award Abstracts, A1055–A1055. https://doi.org/10.1136/jitc-2022-sitc2022.1012
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Friedman, C., Carvajal, R., Davar, D., Castanon, E., Ascierto, P., Calvo, E., O’Hara, M., Powell, S., Shapira-Frommer, R., Garralda, E., Renouf, D. J., Perets, R., Yunan, M., Ravindran, P., Hammell, A., O’Brien, S., Xu, K., Wilson, N., Jhatakia, A., … Gutierrez, M. (2022). 592 Phase 1/2a study of the novel nonfucosylated anti–CTLA-4 monoclonal antibody BMS-986218 ± nivolumab in advanced solid tumors: part 1 results. Regular and Young Investigator Award Abstracts, A620–A621. https://doi.org/10.1136/jitc-2022-sitc2022.0592
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Liao, C.-Y., Johnson, B., Spira, A., Carbone, D., Henick, B., Overman, M., Polite, B., Roychowdhury, S., Mahipal, A., Ahn, D., Johnson, M., Schenk, D., Bae, K., Davis, M., Jooss, K., Ferguson, A., & Solomon, B. (2022). 660 Clinicopathologic characteristics of patients with metastatic colorectal cancer with molecular responses following treatment with an individualized neoantigen vaccine regimen. Regular and Young Investigator Award Abstracts, A691–A691. https://doi.org/10.1136/jitc-2022-sitc2022.0660
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Stein, M., Goodman, O., Dorff, T., Narayan, V., Avitia, J., McKay, R., Nordquist, L., Rettig, M., Schweizer, M., Thomas, R., Silverman, M., Yao, L., Clynes, R., & Shorr, J. (2022). 668 A phase 2 study of vudalimab, a PD-1 x CTLA-4 bispecific antibody, plus chemotherapy or targeted therapy in patients with molecularly defined subtypes of metastatic castration-resistant prostate cancer. Regular and Young Investigator Award Abstracts, A698–A698. https://doi.org/10.1136/jitc-2022-sitc2022.0668
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Hou, J., Goodman, O., Berz, D., Yao, L., & Soni, N. (2022). 733 A phase 2 study of vudalimab (XmAb®20717), an anti-PD-1/CTLA-4 bispecific antibody, in patients with selected gynecological malignancies and high-risk metastatic castration-resistant prostate-cancer. Regular and Young Investigator Award Abstracts, A765–A765. https://doi.org/10.1136/jitc-2022-sitc2022.0733
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Sharma, M., Lathers, D., Johnson, M., Luke, J., Puzanov, I., Curti, B., Chen, C., El-Khoueiry, A., Henick, B., Callahan, M., Sznol, M., Patel, S., Wilson, D., Ricker, M., Cao, L., Jayaraman, P., Che, J., Peng, L., Feltquate, D., … Tolcher, A. (2022). 772 A phase 1/2 dose escalation/expansion study evaluating the safety, pharmacokinetics, pharmacodynamics, and antitumor activity of E-602, a bi-sialidase fusion protein, in advanced cancer (GLIMMER-01). Regular and Young Investigator Award Abstracts, A803–A803. https://doi.org/10.1136/jitc-2022-sitc2022.0772
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Hamid, O., Chiappori, A. A., Thompson, J. A., Doi, T., Hu-Lieskovan, S., Eskens, F. A. L. M., Ros, W., Diab, A., Spano, J.-P., Rizvi, N. A., Wasser, J. S., Angevin, E., Ott, P. A., Forgie, A., Yang, W., Guo, C., Chou, J., & El-Khoueiry, A. B. (2022). First-in-human study of an OX40 (ivuxolimab) and 4-1BB (utomilumab) agonistic antibody combination in patients with advanced solid tumors. Journal for ImmunoTherapy of Cancer, 10(10), e005471. https://doi.org/10.1136/jitc-2022-005471
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Dercle, L., McGale, J., Sun, S., Marabelle, A., Yeh, R., Deutsch, E., Mokrane, F.-Z., Farwell, M., Ammari, S., Schoder, H., Zhao, B., & Schwartz, L. H. (2022). Artificial intelligence and radiomics: fundamentals, applications, and challenges in immunotherapy. Journal for ImmunoTherapy of Cancer, 10(9), e005292. https://doi.org/10.1136/jitc-2022-005292
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Sanborn, R. E., Pishvaian, M. J., Callahan, M. K., Weise, A., Sikic, B. I., Rahma, O., Cho, D. C., Rizvi, N. A., Sznol, M., Lutzky, J., Bauman, J. E., Bitting, R. L., Starodub, A., Jimeno, A., Reardon, D. A., Kaley, T., Iwamoto, F., Baehring, J. M., Subramaniam, D. S., … Keler, T. (2022). Safety, tolerability and efficacy of agonist anti-CD27 antibody (varlilumab) administered in combination with anti-PD-1 (nivolumab) in advanced solid tumors. Journal for ImmunoTherapy of Cancer, 10(8), e005147. https://doi.org/10.1136/jitc-2022-005147
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Henick, B. S., Villarroel-Espindola, F., Datar, I., Sanmamed, M. F., Yu, J., Desai, S., Li, A., Aguirre-Ducler, A., Syrigos, K., Rimm, D. L., Chen, L., Herbst, R. S., & Schalper, K. A. (2022). Quantitative tissue analysis and role of myeloid cells in non-small cell lung cancer. Journal for ImmunoTherapy of Cancer, 10(7), e005025. https://doi.org/10.1136/jitc-2022-005025
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de Vries, E. G., & Schwartz, L. H. (2022). Perspectives on imaging and immunotherapy: a review series. Journal for ImmunoTherapy of Cancer, 10(6), e005006. https://doi.org/10.1136/jitc-2022-005006
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Govindan, R., Aggarwal, C., Antonia, S. J., Davies, M., Dubinett, S. M., Ferris, A., Forde, P. M., Garon, E. B., Goldberg, S. B., Hassan, R., Hellmann, M. D., Hirsch, F. R., Johnson, M. L., Malik, S., Morgensztern, D., Neal, J. W., Patel, J. D., Rimm, D. L., Sagorsky, S., … Herbst, R. S. (2022). Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of lung cancer and mesothelioma. Journal for ImmunoTherapy of Cancer, 10(5), e003956. https://doi.org/10.1136/jitc-2021-003956
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Schöffski, P., Tan, D. S. W., Martín, M., Ochoa-de-Olza, M., Sarantopoulos, J., Carvajal, R. D., Kyi, C., Esaki, T., Prawira, A., Akerley, W., De Braud, F., Hui, R., Zhang, T., Soo, R. A., Maur, M., Weickhardt, A., Krauss, J., Deschler-Baier, B., Lau, A., … Hong, D. S. (2022). Phase I/II study of the LAG-3 inhibitor ieramilimab (LAG525) ± anti-PD-1 spartalizumab (PDR001) in patients with advanced malignancies. Journal for ImmunoTherapy of Cancer, 10(2), e003776. https://doi.org/10.1136/jitc-2021-003776
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He, X., Zhou, S., Dolan, M., Shi, Y., Wang, J., Quinn, B., Jahagirdar, D., Huang, W.-C., Tsuji, M., Pili, R., Ito, F., Ortega, J., Abrams, S. I., Ebos, J. M. L., & Lovell, J. F. (2021). Immunization with short peptide particles reveals a functional CD8+T-cell neoepitope in a murine renal carcinoma model. Journal for ImmunoTherapy of Cancer, 9(12), e003101. https://doi.org/10.1136/jitc-2021-003101
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