Clinical Cancer Research
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Kim, W. Seog., Shortt, J., Zinzani, P. L., Mikhailova, N., Radeski, D., Ribrag, V., Domingo Domenech, E., Sawas, A., Alexis, K., Emig, M., Elbadri, R., Hajela, P., Ravenstijn, P., Pinto, S., Garcia, L., Overesch, A., Pietzko, K., & Horwitz, S. (2024). A Phase 2 study of acimtamig (AFM13) in patients with CD30-positive, relapsed or refractory peripheral T-cell lymphomas. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.ccr-24-1913
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Iwamoto, F. M., Tanguturi, S. K., Nayak, L., Wang, T. J., Desai, A., Lustig, R. A., Bagley, S., Wong, E. T., Hertan, L. M., McCluskey, C., Hayden, J., Muzikansky, A., Nakhawa, S., Japo, J., Bossi, C. C., Meylan, M., Tian, Y., Barlow, G. L., Speliakos, P., … Reardon, D. A. (2024). Re-Irradiation Plus Pembrolizumab: A Phase II Study for Patients with Recurrent Glioblastoma. Clinical Cancer Research, OF1–OF12. https://doi.org/10.1158/1078-0432.ccr-24-1629
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Dallos, M. C., Obradovic, A. Z., McCann, P., Chowdhury, N., Pratapa, A., Aggen, D. H., Gaffney, C., Autio, K. A., Virk, R. K., De Marzo, A. M., Antonarakis, E. S., Scher, H. I., Drake, C. G., & Rathkopf, D. E. (2024). Androgen Deprivation Therapy Drives a Distinct Immune Phenotype in Localized Prostate Cancer. Clinical Cancer Research, 30(22), 5218–5230. https://doi.org/10.1158/1078-0432.ccr-24-0060
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Ma, K. L., Mitchell, T. C., Dougher, M., Sharon, C. E., Tortorello, G. N., Elder, D. E., Morgan, E. E., Gimotty, P. A., Huang, A. C., Amaravadi, R. K., Schuchter, L. M., Flowers, A., Miura, J. T., Karakousis, G. C., & Xu, X. (2024). Tumor-Infiltrating Lymphocytes in Necrotic Tumors after Melanoma Neoadjuvant Anti–PD-1 Therapy Correlate with Pathologic Response and Recurrence-Free Survival. Clinical Cancer Research, 30(21), 4987–4994. https://doi.org/10.1158/1078-0432.ccr-23-3775
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Ventin, M., Cattaneo, G., Arya, S., Jia, J., Gelmi, M. C., Sun, Y., Maggs, L., Ksander, B. R., Verdijk, R. M., Boland, G. M., Jenkins, R. W., Haq, R., Jager, M. J., Wang, X., Ryeom, S., & Ferrone, C. R. (2024). Chimeric Antigen Receptor T Cell with an Inducible Caspase-9 Suicide Gene Eradicates Uveal Melanoma Liver Metastases via B7-H3 Targeting. Clinical Cancer Research, 30(15), 3243–3258. https://doi.org/10.1158/1078-0432.ccr-24-0071
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Luthria, K., Shah, P., Caldwell, B., Melms, J. C., Abuzaid, S., Jakubikova, V., Brodtman, D. Z., Bose, S., Amin, A. D., Ho, P., Biermann, J., Tagore, S., Ingham, M., Schwartz, G. K., & Izar, B. (2024). Single-cell profiling of sarcomas from archival tissue reveals programs associated with resistance to immune checkpoint blockade. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.ccr-23-2976
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Lenis, A. T., Ravichandran, V., Brown, S., Alam, S. M., Katims, A., Truong, H., Reisz, P. A., Vasselman, S., Nweji, B., Autio, K. A., Morris, M. J., Slovin, S. F., Rathkopf, D., Danila, D., Woo, S., Vargas, H. A., Laudone, V. P., Ehdaie, B., Reuter, V., … Abida, W. (2024). Microsatellite Instability, Tumor Mutational Burden, and Response to Immune Checkpoint Blockade in Patients with Prostate Cancer. Clinical Cancer Research, OF1–OF10. https://doi.org/10.1158/1078-0432.ccr-23-3403
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Xu-Monette, Z. Y., Li, Y., Snyder, T., Yu, T., Lu, T., Tzankov, A., Visco, C., Bhagat, G., Qian, W., Dybkaer, K., Chiu, A., Tam, W., Zu, Y., Hsi, E. D., Hagemeister, F. B., Wang, Y., Go, H., Ponzoni, M., Ferreri, A. J. M., … Young, K. H. (2023). Tumor-Infiltrating Normal B Cells Revealed by Immunoglobulin Repertoire Clonotype Analysis Are Highly Prognostic and Crucial for Antitumor Immune Responses in DLBCL. Clinical Cancer Research, 29(23), 4808–4821. https://doi.org/10.1158/1078-0432.ccr-23-1554
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Guercio, B. J., Sarfaty, M., Teo, M. Y., Ratna, N., Duzgol, C., Funt, S. A., Lee, C.-H., Aggen, D. H., Regazzi, A. M., Chen, Z., Lattanzi, M., Al-Ahmadie, H. A., Brannon, A. R., Shah, R., Chu, C., Lenis, A. T., Pietzak, E., Bochner, B. H., Berger, M. F., … Iyer, G. (2023). Clinical and Genomic Landscape of FGFR3-Altered Urothelial Carcinoma and Treatment Outcomes with Erdafitinib: A Real-World Experience. Clinical Cancer Research, 29(22), 4586–4595. https://doi.org/10.1158/1078-0432.ccr-23-1283
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Paolino, J., Dimitrov, B., Apsel Winger, B., Sandoval-Perez, A., Rangarajan, A. V., Ocasio-Martinez, N., Tsai, H. K., Li, Y., Robichaud, A. L., Khalid, D., Hatton, C., Gillani, R., Polonen, P., Dilig, A., Gotti, G., Kavanagh, J., Adhav, A. A., Gow, S., Tsai, J., … Pikman, Y. (2023). Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma. Clinical Cancer Research, 29(22), 4613–4626. https://doi.org/10.1158/1078-0432.ccr-22-2562
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Kinslow, C. J., Rae, A. I., Taparra, K., Kumar, P., Siegelin, M. D., Grinband, J., Gill, B. J. A., McKhann, G. M., Sisti, M. B., Bruce, J. N., Canoll, P. D., Iwamoto, F. M., Horowitz, D. P., Kachnic, L. A., Neugut, A. I., Yu, J. B., Cheng, S. K., & Wang, T. J. C. (2023). MGMT Promoter Methylation Predicts Overall Survival after Chemotherapy for 1p/19q-Codeleted Gliomas. Clinical Cancer Research, 29(21), 4399–4407. https://doi.org/10.1158/1078-0432.ccr-23-1295
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Columbia Affiliation
Vagelos College of Physicians and Surgeons; Department of Radiation Oncology; Department of Pathology and Cell Biology; Department of Psychiatry; Division of Experimental Therapeutics; Department of Neurosurgery; Department of Neurology; Department of Medicine; Division of Hematology/Oncology; Department of Epidemiology; Herbert Irving Comprehensive Cancer Center; Mailman School of Public Health
Jain, M. D., Miklos, D. B., Jacobson, C. A., Timmerman, J. M., Sun, J., Nater, J., Fang, X., Patel, A., Davis, M., Heeke, D., Trinh, T., Mattie, M., Neumann, F., Kim, J. J., To, C., Filosto, S., & Reshef, R. (2023). Axicabtagene Ciloleucel in Combination with the 4–1BB Agonist Utomilumab in Patients with Relapsed/Refractory Large B-Cell Lymphoma: Phase 1 Results from ZUMA-11. Clinical Cancer Research, 29(20), 4118–4127. https://doi.org/10.1158/1078-0432.ccr-23-0916
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Johnson, M., Bell, A., Lauing, K. L., Ladomersky, E., Zhai, L., Penco-Campillo, M., Shah, Y., Mauer, E., Xiu, J., Nicolaides, T., Drumm, M., McCortney, K., Elemento, O., Kim, M., Bommi, P., Low, J. T., Memon, R., Wu, J., Zhao, J., … Wainwright, D. A. (2023). Advanced Age in Humans and Mouse Models of Glioblastoma Show Decreased Survival from Extratumoral Influence. Clinical Cancer Research, 29(23), 4973–4989. https://doi.org/10.1158/1078-0432.ccr-23-0834
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Ingham, M., Lee, S., Van Tine, B. A., Choy, E., Oza, J., Doshi, S., Ge, L., Oppelt, P., Cote, G., Corgiat, B., Sender, N., Sta Ana, S., Panchalingam, L., Petricoin, E., & Schwartz, G. K. (2022). A Single-Arm Phase II Trial of Sitravatinib in Advanced Well-Differentiated/Dedifferentiated Liposarcoma. Clinical Cancer Research, 29(6), 1031–1039. https://doi.org/10.1158/1078-0432.ccr-22-3351
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Sivakumar, S., Jin, D. X., Rathod, R., Ross, J., Cantley, L. C., Scaltriti, M., Chen, J. W., Hutchinson, K. E., Wilson, T. R., Sokol, E. S., & Vasan, N. (2023). Genetic Heterogeneity and Tissue-specific Patterns of Tumors with MultiplePIK3CAMutations. Clinical Cancer Research, 29(6), 1125–1136. https://doi.org/10.1158/1078-0432.ccr-22-2270
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Mezghani, N., Yao, A., Vasilyeva, D., Kaplan, N., Shackelford, A., Yoon, A., Phillipone, E., Dubey, S., Schwartz, G. K., Taylor, A. M., & Momen-Heravi, F. (2022). Molecular Subtypes of Head and Neck Cancer in Patients of African Ancestry. Clinical Cancer Research, 29(5), 910–920. https://doi.org/10.1158/1078-0432.ccr-22-2258
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Columbia Affiliation
College of Dental Medicine; Section of Oral, Diagnostic, and Rehabilitation Sciences; Department of Pathology and Cell Biology; Vagelos College of Physicians and Surgeons; Section of Hospital Dentistry; Division of Oral and Maxillofacial Pathology; Division of Hematology/Oncology; Department of Medicine; Herbert Irving Comprehensive Cancer Center
Peng, K., Zhang, F., Wang, Y., Sahgal, P., Li, T., Zhou, J., Liang, X., Zhang, Y., Sethi, N., Liu, T., Zhang, H., & Bass, A. J. (2022). Development of Combination Strategies for Focal Adhesion Kinase Inhibition in Diffuse Gastric Cancer. Clinical Cancer Research, 29(1), 197–208. https://doi.org/10.1158/1078-0432.ccr-22-1609
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Shankar, L. K., Huang, E., Litiere, S., Hoekstra, O. S., Schwartz, L., Collette, S., Boellaard, R., Bogaerts, J., Seymour, L., & deVries, E. G. E. (2022). Meta-Analysis of the Test–Retest Repeatability of [18F]-Fluorodeoxyglucose Standardized Uptake Values: Implications for Assessment of Tumor Response. Clinical Cancer Research, 29(1), 143–153. https://doi.org/10.1158/1078-0432.ccr-21-3143
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Lim, E. A., Bendell, J. C., Falchook, G. S., Bauer, T. M., Drake, C. G., Choe, J. H., George, D. J., Karlix, J. L., Ulahannan, S., Sachsenmeier, K. F., Russell, D. L., Moorthy, G., Sidders, B. S., Pilling, E. A., Chen, H., Hattersley, M. M., Das, M., Kumar, R., Pouliot, G. P., & Patel, M. R. (2022). Phase Ia/b, Open-Label, Multicenter Study of AZD4635 (an Adenosine A2A Receptor Antagonist) as Monotherapy or Combined with Durvalumab, in Patients with Solid Tumors. Clinical Cancer Research, 28(22), 4871–4884. https://doi.org/10.1158/1078-0432.ccr-22-0612
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Goldman, J. W., Piha-Paul, S. A., Curti, B., Pedersen, K. S., Bauer, T. M., Groenland, S. L., Carvajal, R. D., Chhaya, V., Kirby, G., McGlinchey, K., Hammond, S. A., Streicher, K., Townsley, D. M., Chae, Y. K., Voortman, J., Marabelle, A., & Powderly, J. (2022). Safety and Tolerability of MEDI0562, an OX40 Agonist mAb, in Combination with Durvalumab or Tremelimumab in Adult Patients with Advanced Solid Tumors. Clinical Cancer Research, 28(17), 3709–3719. https://doi.org/10.1158/1078-0432.ccr-21-3016
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Gaydosik, A. M., Stonesifer, C. J., Khaleel, A. E., Geskin, L. J., & Fuschiotti, P. (2022). Single-Cell RNA Sequencing Unveils the Clonal and Transcriptional Landscape of Cutaneous T-Cell Lymphomas. Clinical Cancer Research, 28(12), 2610–2622. https://doi.org/10.1158/1078-0432.ccr-21-4437
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Lassman, A. B., Sepúlveda-Sánchez, J. M., Cloughesy, T. F., Gil-Gil, M. J., Puduvalli, V. K., Raizer, J. J., De Vos, F. Y. F., Wen, P. Y., Butowski, N. A., Clement, P. M. J., Groves, M. D., Belda-Iniesta, C., Giglio, P., Soifer, H. S., Rowsey, S., Xu, C., Avogadri, F., Wei, G., Moran, S., & Roth, P. (2022). Infigratinib in Patients with Recurrent Gliomas and FGFR Alterations: A Multicenter Phase II Study. Clinical Cancer Research, 28(11), 2270–2277. https://doi.org/10.1158/1078-0432.ccr-21-2664
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Obradovic, A., Graves, D., Korrer, M., Wang, Y., Roy, S., Naveed, A., Xu, Y., Luginbuhl, A., Curry, J., Gibson, M., Idrees, K., Hurley, P., Jiang, P., Liu, X. S., Uppaluri, R., Drake, C. G., Califano, A., & Kim, Y. J. (2022). Immunostimulatory Cancer-Associated Fibroblast Subpopulations Can Predict Immunotherapy Response in Head and Neck Cancer. Clinical Cancer Research, 28(10), 2094–2109. https://doi.org/10.1158/1078-0432.ccr-21-3570
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Columbia Affiliation
Vagelos College of Physicians and Surgeons; Department of Medicine; Division of Hematology/Oncology; Department of Urology; Department of Systems Biology; Department of Biochemistry and Molecular Biophysics; Department of Biomedical Informatics; Center for Translational Immunology; Herbert Irving Comprehensive Cancer Center; JP Sulzberger Columbia Genome Center
Rosenblat, T. L., McDevitt, M. R., Carrasquillo, J. A., Pandit-Taskar, N., Frattini, M. G., Maslak, P. G., Park, J. H., Douer, D., Cicic, D., Larson, S. M., Scheinberg, D. A., & Jurcic, J. G. (2022). Treatment of Patients with Acute Myeloid Leukemia with the Targeted Alpha-Particle Nanogenerator Actinium-225-Lintuzumab. Clinical Cancer Research, 28(10), 2030–2037. https://doi.org/10.1158/1078-0432.ccr-21-3712
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Nguyen, T. T. T., Shang, E., Schiffgens, S., Torrini, C., Shu, C., Akman, H. O., Prabhu, V. V., Allen, J. E., Westhoff, M.-A., Karpel-Massler, G., & Siegelin, M. D. (2022). Induction of Synthetic Lethality by Activation of Mitochondrial ClpP and Inhibition of HDAC1/2 in Glioblastoma. Clinical Cancer Research, 28(9), 1881–1895. https://doi.org/10.1158/1078-0432.ccr-21-2857
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Gounder, M. M., Rosenbaum, E., Wu, N., Dickson, M. A., Sheikh, T. N., D’Angelo, S. P., Chi, P., Keohan, M. L., Erinjeri, J. P., Antonescu, C. R., Agaram, N., Hameed, M. R., Martindale, M., Lefkowitz, R. A., Crago, A. M., Singer, S., Tap, W. D., Takebe, N., Qin, L.-X., & Schwartz, G. K. (2022). A Phase Ib/II Randomized Study of RO4929097, a Gamma-Secretase or Notch Inhibitor with or without Vismodegib, a Hedgehog Inhibitor, in Advanced Sarcoma. Clinical Cancer Research, 28(8), 1586–1594. https://doi.org/10.1158/1078-0432.ccr-21-3874
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Diamond, J. R., Boni, V., Lim, E., Nowakowski, G., Cordoba, R., Morillo, D., Valencia, R., Genvresse, I., Merz, C., Boix, O., Frigault, M. M., Greer, J. M., Hamdy, A. M., Huang, X., Izumi, R., Wong, H., & Moreno, V. (2022). First-in-Human Dose-Escalation Study of Cyclin-Dependent Kinase 9 Inhibitor VIP152 in Patients with Advanced Malignancies Shows Early Signs of Clinical Efficacy. Clinical Cancer Research, 28(7), 1285–1293. https://doi.org/10.1158/1078-0432.ccr-21-3617
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Xu-Monette, Z. Y., Wei, L., Fang, X., Au, Q., Nunns, H., Nagy, M., Tzankov, A., Zhu, F., Visco, C., Bhagat, G., Dybkaer, K., Chiu, A., Tam, W., Zu, Y., Hsi, E. D., Hagemeister, F. B., Sun, X., Han, X., Go, H., … Young, K. H. (2022). Genetic Subtyping and Phenotypic Characterization of the Immune Microenvironment and MYC/BCL2 Double Expression Reveal Heterogeneity in Diffuse Large B-cell Lymphoma. Clinical Cancer Research, 28(5), 972–983. https://doi.org/10.1158/1078-0432.ccr-21-2949
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Viny, A. D. (2021). DNMT3A-Mutant Leukemia Cells Primed to “Fork It Over” under DNA Damage. Clinical Cancer Research, 28(4), 573–575. https://doi.org/10.1158/1078-0432.ccr-21-3949
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Meric-Bernstam, F., Sweis, R. F., Hodi, F. S., Messersmith, W. A., Andtbacka, R. H. I., Ingham, M., Lewis, N., Chen, X., Pelletier, M., Chen, X., Wu, J., Dubensky, T. W., McWhirter, S. M., Müller, T., Nair, N., & Luke, J. J. (2021). Phase I Dose-Escalation Trial of MIW815 (ADU-S100), an Intratumoral STING Agonist, in Patients with Advanced/Metastatic Solid Tumors or Lymphomas. Clinical Cancer Research, 28(4), 677–688. https://doi.org/10.1158/1078-0432.ccr-21-1963
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Mato, A. R., Davids, M. S., Sharman, J., Roeker, L. E., Kay, N., Kater, A. P., Rogers, K., Thompson, M. C., Rhodes, J., Goy, A., Skarbnik, A., Schuster, S. J., Tam, C. S., Eyre, T. A., O’Brien, S., Nabhan, C., Lamanna, N., Sun, C., Shadman, M., … Woyach, J. A. (2021). Recognizing Unmet Need in the Era of Targeted Therapy for CLL/SLL: “What’s Past Is Prologue” (Shakespeare). Clinical Cancer Research, 28(4), 603–608. https://doi.org/10.1158/1078-0432.ccr-21-1237
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Lassman, A. B., Wen, P. Y., van den Bent, M. J., Plotkin, S. R., Walenkamp, A. M. E., Green, A. L., Li, K., Walker, C. J., Chang, H., Tamir, S., Henegar, L., Shen, Y., Alvarez, M. J., Califano, A., Landesman, Y., Kauffman, M. G., Shacham, S., & Mau-Sørensen, M. (2021). A Phase II Study of the Efficacy and Safety of Oral Selinexor in Recurrent Glioblastoma. Clinical Cancer Research, 28(3), 452–460. https://doi.org/10.1158/1078-0432.ccr-21-2225
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Department of Neurology; Department of Systems Biology; Vagelos College of Physicians and Surgeons; Department of Biochemistry and Molecular Biophysics; Department of Biomedical Informatics; Department of Medicine; Division of Hematology/Oncology; Department of Neurosurgery; Division of Neuro-Oncology; Herbert Irving Comprehensive Cancer Center
Palmer, A. C., Izar, B., Hwangbo, H., & Sorger, P. K. (2022). Predictable Clinical Benefits without Evidence of Synergy in Trials of Combination Therapies with Immune-Checkpoint Inhibitors. Clinical Cancer Research, 28(2), 368–377. https://doi.org/10.1158/1078-0432.ccr-21-2275
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