R56AG058661

NIH – National Institute On Aging

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Traumatic Brain Injury-Induced Fear Generalization in Mice Involves Hippocampal Memory Trace Dysfunction and Is Alleviated by (R,S)-Ketamine

McGowan, J. C., Ladner, L. R., Shubeck, C. X., Tapia, J., LaGamma, C. T., Anqueira-González, A., DeFrancesco, A., Chen, B. K., Hunsberger, H. C., Sydnor, E. J., Logan, R. W., Yu, T.-S., Kernie, S. G., & Denny, C. A. (2024). Traumatic Brain Injury–Induced Fear Generalization in Mice Involves Hippocampal Memory Trace Dysfunction and Is Alleviated by (R,S)-Ketamine. Biological Psychiatry, 95(1), 15–26. https://doi.org/10.1016/j.biopsych.2023.06.030
Authors:
Josephine C McGowan
Liliana R Ladner
Claire X Shubeck
Juliana Tapia
Christina T LaGamma
Amanda Anqueira-González
Ariana DeFrancesco
Briana K Chen
Holly C Hunsberger
Ezra J Sydnor
Ryan W Logan
Tzong-Shiue Yu
Steven G Kernie
Christine A Denny
Affiliated Authors:
Josephine C McGowan
Christina T LaGamma
Amanda Anqueira-González
Briana K Chen
Tzong-Shiue Yu
Steven G Kernie
Christine A Denny
Columbia Affiliation:
Subjects:
Ketamine (MeSH)
Brain Injuries, Traumatic (MeSH)
Author Keywords:
(r,s)-ketamine
amygdala
fear
hippocampus
memory
tbi
Grants:
R01HD101402 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)
T32HD007430 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)
T32MH015174 (NIH – National Institute of Mental Health)
F31MH121023 (NIH – National Institute of Mental Health)
F31MH122187 (NIH – National Institute of Mental Health)
R56NS089523 (NIH – National Institute of Neurological Disorders and Stroke)
F99NS124182 (NIH – National Institute of Neurological Disorders and Stroke)
R21NS114870 (NIH – National Institute of Neurological Disorders and Stroke)
R01NS095803 (NIH – National Institute of Neurological Disorders and Stroke)
R21AG064774 (NIH – National Institute On Aging)
R00AG059953 (NIH – National Institute On Aging)
K99AG059953 (NIH – National Institute On Aging)
R56AG058661 (NIH – National Institute On Aging)
DP5OD017908 (NIH – Office of the Director, National Institutes of Health)
Publication Type:
Article
Unique ID:
10.1016/j.biopsych.2023.06.030
PMID:
37423591
DOI:
10.1016/j.biopsych.2023.06.030
Journal:
Biological Psychiatry
Publication Date:
Data Source:
PubMed
Source Link:
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Prophylactic (R,S)-Ketamine Is Effective Against Stress-Induced Behaviors in Adolescent but Not Aged Mice

Mastrodonato, A., Pavlova, I., Kee, N. C., Pham, V. A., McGowan, J. C., Mann, J. J., & Denny, C. A. (2022). Prophylactic (R,S)-Ketamine Is Effective Against Stress-Induced Behaviors in Adolescent but Not Aged Mice. International Journal of Neuropsychopharmacology, 25(6), 512–523. https://doi.org/10.1093/ijnp/pyac020
Authors:
Alessia Mastrodonato
Ina Pavlova
Noelle C. Kee
Van Anh Pham
Josephine C. Mcgowan
J. John Mann
Christine A. Denny
Affiliated Authors:
Alessia Mastrodonato
Ina Pavlova
Josephine C. Mcgowan
J. John Mann
Christine A. Denny
Columbia Affiliation:
Subjects:
Neuroimmune Interaction in Psychiatric Disorders (OpenAlex Topic)
Molecular Mechanisms of Depression Treatment Strategies (OpenAlex Topic)
Effects of Stress on Brain Function and Health (OpenAlex Topic)
Ketamine (MeSH)
Author Keywords:
(r
s)-ketamine
adolescence
aging
(r,s)-ketamine
Grants:
R01HD101402 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)
R01MH108032 (NIH – National Institute of Mental Health)
F31MH122187 (NIH – National Institute of Mental Health)
R21NS114870 (NIH – National Institute of Neurological Disorders and Stroke)
F99NS124182 (NIH – National Institute of Neurological Disorders and Stroke)
R56AG058661 (NIH – National Institute On Aging)
R21AG064774 (NIH – National Institute On Aging)
Publication Type:
Article
Unique ID:
10.1093/ijnp/pyac020
PMID:
35229871
DOI:
10.1093/ijnp/pyac020
Journal:
International Journal of Neuropsychopharmacology
Publication Date:
Data Source:
Scopus
Source Link:
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Fluoroethylnormemantine, a Novel NMDA Receptor Antagonist, for the Prevention and Treatment of Stress-Induced Maladaptive Behavior

Chen, B. K., Luna, V. M., Shannon, M. E., Hunsberger, H. C., Mastrodonato, A., Stackmann, M., McGowan, J. C., Rubinstenn, G., & Denny, C. A. (2021). Fluoroethylnormemantine, a Novel NMDA Receptor Antagonist, for the Prevention and Treatment of Stress-Induced Maladaptive Behavior. Biological Psychiatry, 90(7), 458–472. https://doi.org/10.1016/j.biopsych.2021.04.024
Authors:
Briana K. Chen
Victor M. Luna
Margaret E. Shannon
Holly C. Hunsberger
Alessia Mastrodonato
Michelle Stackmann
Josephine C. McGowan
Gilles Rubinstenn
Christine A. Denny
Affiliated Authors:
Briana K. Chen
Victor M. Luna
Margaret E. Shannon
Holly C. Hunsberger
Alessia Mastrodonato
Michelle Stackmann
Josephine C. McGowan
Christine A. Denny
Columbia Affiliation:
Subjects:
Depressive Disorder, Major (MeSH)
Ketamine (MeSH)
Memantine (MeSH)
Receptors, N-Methyl-D-Aspartate (MeSH)
Author Keywords:
antidepressant
anxiety
depression
fear
nmdar
prophylactic
Grants:
R01HD101402 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)
F31MH121023 (NIH – National Institute of Mental Health)
R21NS114870 (NIH – National Institute of Neurological Disorders and Stroke)
R21AG064774 (NIH – National Institute On Aging)
K01AG054765 (NIH – National Institute On Aging)
R56AG058661 (NIH – National Institute On Aging)
Publication Type:
Article
Unique ID:
10.1016/j.biopsych.2021.04.024
PMID:
34274107
DOI:
10.1016/j.biopsych.2021.04.024
Journal:
Biological Psychiatry
Publication Date:
Data Source:
Scopus
Source Link:
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Record Created:

Propranolol Decreases Fear Expression by Modulating Fear Memory Traces

Leal Santos, S., Stackmann, M., Muñoz Zamora, A., Mastrodonato, A., De Landri, A. V., Vaughan, N., Chen, B. K., Lanio, M., & Denny, C. A. (2021). Propranolol Decreases Fear Expression by Modulating Fear Memory Traces. Biological Psychiatry, 89(12), 1150–1161. https://doi.org/10.1016/j.biopsych.2021.01.005
Authors:
Sofia Leal Santos
Michelle Stackmann
Andrea Muñoz Zamora
Alessia Mastrodonato
Allegra V. De Landri
Nick Vaughan
Briana K. Chen
Marcos Lanio
Christine A. Denny
Affiliated Authors:
Sofia Leal Santos
Michelle Stackmann
Alessia Mastrodonato
Allegra V. De Landri
Nick Vaughan
Briana K. Chen
Marcos Lanio
Christine A. Denny
Columbia Affiliation:
Subjects:
Basolateral Nuclear Complex (MeSH)
Propranolol (MeSH)
Author Keywords:
arc
contextual fear conditioning
engram
memory
propranolol
trace
c-fos
Grants:
R01HD101402 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)
T32HD007430 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)
F31MH121023 (NIH – National Institute of Mental Health)
R21NS114870 (NIH – National Institute of Neurological Disorders and Stroke)
R56AG058661 (NIH – National Institute On Aging)
R21AG064774 (NIH – National Institute On Aging)
DP5OD017908 (NIH – Office of the Director, National Institutes of Health)
Publication Type:
Article
Unique ID:
10.1016/j.biopsych.2021.01.005
PMID:
33766406
DOI:
10.1016/j.biopsych.2021.01.005
Journal:
Biological Psychiatry
Publication Date:
Data Source:
Scopus
Source Link:
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Fluoroethylnormemantine, A Novel Derivative of Memantine, Facilitates Extinction Learning without Sensorimotor Deficits

Chen, B. K., Le Pen, G., Eckmier, A., Rubinstenn, G., Jay, T. M., & Denny, C. A. (2021). Fluoroethylnormemantine, A Novel Derivative of Memantine, Facilitates Extinction Learning Without Sensorimotor Deficits. International Journal of Neuropsychopharmacology, 24(6), 519–531. https://doi.org/10.1093/ijnp/pyab007
Authors:
Briana K Chen
Gwenaëlle Le Pen
Adam Eckmier
Gilles Rubinstenn
Therese M Jay
Christine A Denny
Affiliated Authors:
Briana K Chen
Christine A Denny
Columbia Affiliation:
Subjects:
Molecular Mechanisms of Synaptic Plasticity and Neurological Disorders (OpenAlex Topic)
Neural Mechanisms of Memory Formation and Spatial Navigation (OpenAlex Topic)
Molecular Mechanisms of Depression Treatment Strategies (OpenAlex Topic)
Behavior, Animal (MeSH)
Excitatory Amino Acid Antagonists (MeSH)
Extinction, Psychological (MeSH)
Fear (MeSH)
Memantine (MeSH)
Receptors, N-Methyl-D-Aspartate (MeSH)
Author Keywords:
fenm
extinction learning
cued fear conditioning
ptsd
nmdar antagonist
Grants:
R01HD101402 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)
F31MH121023 (NIH – National Institute of Mental Health)
R21NS114870 (NIH – National Institute of Neurological Disorders and Stroke)
R21AG064774 (NIH – National Institute On Aging)
R56AG058661 (NIH – National Institute On Aging)
Publication Type:
Article
Unique ID:
10.1093/ijnp/pyab007
PMID:
33631001
DOI:
10.1093/ijnp/pyab007
Journal:
International Journal of Neuropsychopharmacology
Publication Date:
Data Source:
Scopus
Source Link:
View Scopus Record
View PubMed Record
View Web of Science Record
View OpenAlex Record

Record Created:

Behavioral and neurobiological effects of GnRH agonist treatment in mice—potential implications for puberty suppression in transgender individuals

Anacker, C., Sydnor, E., Chen, B. K., LaGamma, C. C., McGowan, J. C., Mastrodonato, A., Hunsberger, H. C., Shores, R., Dixon, R. S., McEwen, B. S., Byne, W., Meyer-Bahlburg, H. F. L., Bockting, W., Ehrhardt, A. A., & Denny, C. A. (2020). Behavioral and neurobiological effects of GnRH agonist treatment in mice—potential implications for puberty suppression in transgender individuals. Neuropsychopharmacology, 46(5), 882–890. https://doi.org/10.1038/s41386-020-00826-1
Authors:
Christoph Anacker
Ezra Sydnor
Briana K. Chen
Christina C. LaGamma
Josephine C. McGowan
Alessia Mastrodonato
Holly C. Hunsberger
Ryan Shores
Rushell S. Dixon
Bruce S. McEwen
William Byne
Heino F. L. Meyer-Bahlburg
Walter Bockting
Anke A. Ehrhardt
Christine A. Denny
Affiliated Authors:
Christoph Anacker
Briana K. Chen
Josephine C. McGowan
Alessia Mastrodonato
Holly C. Hunsberger
Rushell S. Dixon
William Byne
Heino F. L. Meyer-Bahlburg
Walter Bockting
Anke A. Ehrhardt
Christine A. Denny
Columbia Affiliation:
Grants:
R01HD101402 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)
R00MH108719 (NIH – National Institute of Mental Health)
P50MH090964 (NIH – National Institute of Mental Health)
F31MH121023 (NIH – National Institute of Mental Health)
R21NS114870 (NIH – National Institute of Neurological Disorders and Stroke)
R21AG064774 (NIH – National Institute On Aging)
R56AG058661 (NIH – National Institute On Aging)
Publication Type:
Article
Unique ID:
10.1038/s41386-020-00826-1
PMID:
32919399
DOI:
10.1038/s41386-020-00826-1
Journal:
Neuropsychopharmacology
Publication Date:
Data Source:
Scopus
Source Link:
View Scopus Record

Record Created:

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