R01DK121140 | CUIMC Publications

Multiple beta cell-independent mechanisms drive hypoglycemia in Timothy syndrome

Matsui, M., Lynch, L. E., Distefano, I., Galante, A., Gade, A. R., Wang, H.-G., Gómez-Banoy, N., Towers, P., Sinden, D. S., Wei, E. Q., Barnett, A. S., Johnson, K., Lima, R., Rubio-Navarro, A., Li, A. K., Marx, S. O., McGraw, T. E., Thornton, P. S., Timothy, K. W., … Pitt, G. S. (2024). Multiple beta cell-independent mechanisms drive hypoglycemia in Timothy syndrome. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-52885-3

Authors:

Maiko Matsui

Lauren E Lynch

Isabella Distefano

Allison Galante

Aravind R Gade

Hong-Gang Wang

Nicolas Gómez-Banoy

Patrick Towers

Daniel S Sinden

Eric Q Wei

Adam S Barnett

Kenneth Johnson

Renan Lima

Alfonso Rubio-Navarro

Ang K Li

Steven O Marx

Timothy E McGraw

Paul S Thornton

Katherine W Timothy

James C Lo

Geoffrey S Pitt

Affiliated Authors:

Steven O Marx

Columbia Affiliation:

Vagelos College of Physicians and Surgeons
- Department of Medicine
  Seymour, Paul, and Gloria Milstein Division of Cardiology
- Department of Molecular Pharmacology and Therapeutics

Subjects:

Calcium Channels, L-Type (MeSH)

Hypoglycemia (MeSH)

Insulin-Secreting Cells (MeSH)

Syndactyly (MeSH)

Long QT Syndrome (MeSH)

Autistic Disorder (MeSH)

Disease Models, Animal (MeSH)

Grants:

R01HD090132 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)

R01HL151190 (NIH – National Heart, Lung, and Blood Institute)

R01DK121844 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

R01DK121140 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

Publication Type:

Article

Unique ID:

10.1038/s41467-024-52885-3

PMID:

39420001

DOI:

10.1038/s41467-024-52885-3

Journal:

Nature Communications

Publication Date:

2024-10-18

Data Source:

PubMed

Source Link:

View PubMed Record

View Web of Science Record

View Scopus Record

Record Created:

Monday, December 9, 2024 - 15:35

Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells

Aaron, N., Kraakman, M. J., Zhou, Q., Liu, Q., Costa, S., Yang, J., Liu, L., Yu, L., Wang, L., He, Y., Fan, L., Hirakawa, H., Ding, L., Lo, J., Wang, W., Zhao, B., Guo, E., Sun, L., Rosen, C. J., & Qiang, L. (2021). Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells. ELife, 10. CLOCKSS. https://doi.org/10.7554/elife.69209

Authors:

Nicole Aaron

Michael J Kraakman

Qiuzhong Zhou

Qiongming Liu

Samantha Costa

Jing Yang

Longhua Liu

Lexiang Yu

Liheng Wang

Ying He

Lihong Fan

Hiroyuki Hirakawa

Lei Ding

James Lo

Weidong Wang

Baohong Zhao

Edward Guo

Lei Sun

Cliff J Rosen

Li Qiang

Affiliated Authors:

Nicole Aaron

Michael J Kraakman

Qiongming Liu

Jing Yang

Longhua Liu

Lexiang Yu

Liheng Wang

Ying He

Lihong Fan

Hiroyuki Hirakawa

Lei Ding

Edward Guo

Li Qiang

Columbia Affiliation:

Vagelos College of Physicians and Surgeons

Subjects:

Adiposity (MeSH)

Bone Marrow (MeSH)

Complement Factor D (MeSH)

Mesenchymal Stem Cells (MeSH)

Author Keywords:

ppargamma

adipokine

adipsin

bone marrow adiposity

complement

medicine

mouse

Grants:

P01HL087123 (NIH – National Heart, Lung, and Blood Institute)

R01AR068970 (NIH – National Institute of Arthritis and Musculoskeletal and Skin Diseases)

R01AR071463 (NIH – National Institute of Arthritis and Musculoskeletal and Skin Diseases)

F31DK124926 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

R01DK112943 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

R24DK092759 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)