P50CA058236

NIH – National Cancer Institute

Androgen Deprivation Therapy Drives a Distinct Immune Phenotype in Localized Prostate Cancer

Dallos, M. C., Obradovic, A. Z., McCann, P., Chowdhury, N., Pratapa, A., Aggen, D. H., Gaffney, C., Autio, K. A., Virk, R. K., De Marzo, A. M., Antonarakis, E. S., Scher, H. I., Drake, C. G., & Rathkopf, D. E. (2024). Androgen Deprivation Therapy Drives a Distinct Immune Phenotype in Localized Prostate Cancer. Clinical Cancer Research, 30(22), 5218–5230. https://doi.org/10.1158/1078-0432.ccr-24-0060
Authors:
Matthew C Dallos
Aleksandar Z Obradovic
Patrick McCann
Nivedita Chowdhury
Aditya Pratapa
David H Aggen
Christopher Gaffney
Karen A Autio
Renu K Virk
Angelo M De Marzo
Emmanuel S Antonarakis
Howard I Scher
Charles G Drake
Dana E Rathkopf
Affiliated Authors:
Aleksandar Z Obradovic
Renu K Virk
Charles G Drake
Grants:
P30CA008748 (NIH – National Cancer Institute)
P30CA006973 (NIH – National Cancer Institute)
P50CA211024 (NIH – National Cancer Institute)
P50CA092629 (NIH – National Cancer Institute)
P50CA058236 (NIH – National Cancer Institute)
Publication Type:
Article
Unique ID:
10.1158/1078-0432.ccr-24-0060
PMID:
Publication Date:
Data Source:
PubMed

Record Created:

Single-cell protein activity analysis identifies recurrence-associated renal tumor macrophages

Obradovic, A., Chowdhury, N., Haake, S. M., Ager, C., Wang, V., Vlahos, L., Guo, X. V., Aggen, D. H., Rathmell, W. K., Jonasch, E., Johnson, J. E., Roth, M., Beckermann, K. E., Rini, B. I., McKiernan, J., Califano, A., & Drake, C. G. (2021). Single-cell protein activity analysis identifies recurrence-associated renal tumor macrophages. Cell, 184(11), 2988-3005.e16. https://doi.org/10.1016/j.cell.2021.04.038
Authors:
Aleksandar Obradovic
Nivedita Chowdhury
Scott M Haake
Casey Ager
Vinson Wang
Lukas Vlahos
Xinzheng V Guo
David H Aggen
W Kimryn Rathmell
Eric Jonasch
Joyce E Johnson
Marc Roth
Kathryn E Beckermann
Brian I Rini
James McKiernan
Andrea Califano
Charles G Drake
Affiliated Authors:
Aleksandar Obradovic
Nivedita Chowdhury
Casey Ager
Xinzheng V Guo
David H Aggen
Andrea Califano
Charles G Drake
Author Keywords:
cd8 t cell
clear cell renal carcinoma
clustering
gene regulatory networks
immunotherapy
post-surgical recurrence
protein activity inference
single-cell rna sequencing
treg
tumor microenvironment
tumor-infiltrating macrophage
cd8 t cell
Grants:
R01CA127153 (NIH – National Cancer Institute)
R35CA197745 (NIH – National Cancer Institute)
P30CA006973 (NIH – National Cancer Institute)
R01CA217987 (NIH – National Cancer Institute)
R38CA231577 (NIH – National Cancer Institute)
P30CA013696 (NIH – National Cancer Institute)
U01CA217858 (NIH – National Cancer Institute)
P50CA058236 (NIH – National Cancer Institute)
S10OD021764 (NIH – Office of the Director, National Institutes of Health)
S10OD012351 (NIH – Office of the Director, National Institutes of Health)
Publication Type:
Article
Unique ID:
10.1016/j.cell.2021.04.038
PMID:
Journal:
Publication Date:
Data Source:
PubMed

Record Created:

Blocking IL1 Beta Promotes Tumor Regression and Remodeling of the Myeloid Compartment in a Renal Cell Carcinoma Model: Multidimensional Analyses

Aggen, D. H., Ager, C. R., Obradovic, A. Z., Chowdhury, N., Ghasemzadeh, A., Mao, W., Chaimowitz, M. G., Lopez-Bujanda, Z. A., Spina, C. S., Hawley, J. E., Dallos, M. C., Zhang, C., Wang, V., Li, H., Guo, X. V., & Drake, C. G. (2021). Blocking IL1 Beta Promotes Tumor Regression and Remodeling of the Myeloid Compartment in a Renal Cell Carcinoma Model: Multidimensional Analyses. Clinical Cancer Research, 27(2), 608–621. https://doi.org/10.1158/1078-0432.ccr-20-1610
Authors:
David H. Aggen
Casey R. Ager
Aleksandar Z. Obradovic
Nivedita Chowdhury
Ali Ghasemzadeh
Wendy Mao
Matthew G. Chaimowitz
Zoila A. Lopez-Bujanda
Catherine S. Spina
Vinson Wang
Xinzheng Guo
Charles G. Drake
Jessica E. Hawley
Matthew C. Dallos
Hu Li
Cheng Zhang
Affiliated Authors:
David H. Aggen
Casey R. Ager
Aleksandar Z. Obradovic
Nivedita Chowdhury
Ali Ghasemzadeh
Wendy Mao
Matthew G. Chaimowitz
Zoila A. Lopez-Bujanda
Catherine S. Spina
Vinson Wang
Xinzheng Guo
Charles G. Drake
Jessica E. Hawley
Matthew C. Dallos
Hu Li
Grants:
P30CA006973 (NIH – National Cancer Institute)
R01CA127153 (NIH – National Cancer Institute)
R38CA231577 (NIH – National Cancer Institute)
P50CA058236 (NIH – National Cancer Institute)
P30CA008748 (NIH – National Cancer Institute)
Publication Type:
Article
Unique ID:
10.1158/1078-0432.CCR-20-1610
PMID:
Publication Date:
Data Source:
Web of Science

Record Created: