F31AG051381 | CUIMC Publications

GALC variants affect galactosylceramidase enzymatic activity and risk of Parkinson's disease

Senkevich, K., Zorca, C. E., Dworkind, A., Rudakou, U., Somerville, E., Yu, E., Ermolaev, A., Nikanorova, D., Ahmad, J., Ruskey, J. A., Asayesh, F., Spiegelman, D., Fahn, S., Waters, C., Monchi, O., Dauvilliers, Y., Dupré, N., Greenbaum, L., Hassin-Baer, S., … Gan-Or, Z. (2022). GALC variants affect galactosylceramidase enzymatic activity and risk of Parkinson’s disease. Brain, 146(5), 1859–1872. https://doi.org/10.1093/brain/awac413

Authors:

Konstantin Senkevich

Cornelia E Zorca

Aliza Dworkind

Uladzislau Rudakou

Emma Somerville

Eric Yu

Alexey Ermolaev

Daria Nikanorova

Jamil Ahmad

Jennifer A Ruskey

Farnaz Asayesh

Dan Spiegelman

Stanley Fahn

Cheryl Waters

Oury Monchi

Yves Dauvilliers

Nicolas Dupré

Lior Greenbaum

Sharon Hassin-Baer

Francis P Grenn

Ming Sum Ruby Chiang

S Pablo Sardi

Benoît Vanderperre

Cornelis Blauwendraat

Jean-François Trempe

Edward A Fon

Thomas M Durcan

Roy N Alcalay

Ziv Gan-Or

Affiliated Authors:

Stanley Fahn

Cheryl Waters

Roy N Alcalay

Columbia Affiliation:

Subjects:

Parkinson Disease (MeSH)

Author Keywords:

galactosylceramidase

gba1

genome-wide association study

parkinson’s disease

sphingolipid pathway

Grants:

UL1TR000040 (NIH – National Center for Advancing Translational Sciences)

R01MH097276 (NIH – National Institute of Mental Health)

P50MH084051 (NIH – National Institute of Mental Health)

R01MH093725 (NIH – National Institute of Mental Health)

R01MH110921 (NIH – National Institute of Mental Health)

P50MH084053 (NIH – National Institute of Mental Health)

R01MH109897 (NIH – National Institute of Mental Health)

R01MH085542 (NIH – National Institute of Mental Health)

R01MH075916 (NIH – National Institute of Mental Health)

P50MH096891 (NIH – National Institute of Mental Health)

R01MH109677 (NIH – National Institute of Mental Health)

P50MH066392 (NIH – National Institute of Mental Health)

U01MH103392 (NIH – National Institute of Mental Health)

R37MH057881 (NIH – National Institute of Mental Health)

R01NS080820 (NIH – National Institute of Neurological Disorders and Stroke)

U24NS072026 (NIH – National Institute of Neurological Disorders and Stroke)

K02NS080915 (NIH – National Institute of Neurological Disorders and Stroke)

P30AG019610 (NIH – National Institute On Aging)

R01AG015819 (NIH – National Institute On Aging)

U01AG046139 (NIH – National Institute On Aging)

R01AG032990 (NIH – National Institute On Aging)

R01AG048015 (NIH – National Institute On Aging)

P50AG016574 (NIH – National Institute On Aging)

R01AG017917 (NIH – National Institute On Aging)

R01AG018023 (NIH – National Institute On Aging)

F31AG051381 (NIH – National Institute On Aging)

R01AG036836 (NIH – National Institute On Aging)

U01AG046152 (NIH – National Institute On Aging)

P30AG010161 (NIH – National Institute On Aging)

P01AG017216 (NIH – National Institute On Aging)

U01AG006786 (NIH – National Institute On Aging)

P01AG002219 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1093/brain/awac413

PMID:

36370000

DOI:

10.1093/brain/awac413

Journal:

Brain

Publication Date:

2023-05-02

Data Source:

PubMed

Source Link:

View PubMed Record

View Scopus Record

Record Created:

Tuesday, August 13, 2024 - 10:53

Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease

Eissman, J. M., Dumitrescu, L., Mahoney, E. R., Smith, A. N., Mukherjee, S., Lee, M. L., Scollard, P., Choi, S. E., Bush, W. S., Engelman, C. D., Lu, Q., Fardo, D. W., Trittschuh, E. H., Mez, J., Kaczorowski, C. C., Hernandez Saucedo, H., Widaman, K. F., Buckley, R. F., Properzi, M. J., … Hohman, T. J. (2022). Sex differences in the genetic architecture of cognitive resilience to Alzheimer’s disease. Brain, 145(7), 2541–2554. https://doi.org/10.1093/brain/awac177

Authors:

Jaclyn M Eissman

Logan Dumitrescu

Emily R Mahoney

Alexandra N Smith

Shubhabrata Mukherjee

Michael L Lee

Phoebe Scollard

Seo Eun Choi

William S Bush

Corinne D Engelman

Qiongshi Lu

David W Fardo

Emily H Trittschuh

Jesse Mez

Catherine C Kaczorowski

Hector Hernandez Saucedo

Keith F Widaman

Rachel F Buckley

Michael J Properzi

Elizabeth C Mormino

Hyun Sik Yang

Theresa M Harrison

Trey Hedden

Kwangsik Nho

Shea J Andrews

Douglas Tommet

Niran Hadad

R. Elizabeth Sanders

Douglas M Ruderfer

Katherine A Gifford

Xiaoyuan Zhong

Neha S Raghavan

Badri N Vardarajan

Margaret A Pericak-Vance

Lindsay A Farrer

Li San Wang

Carlos Cruchaga

Gerard D Schellenberg

Nancy J Cox

Jonathan L Haines

C. Dirk Keene

Andrew J Saykin

Eric B Larson

Reisa A Sperling

Richard Mayeux

Michael L Cuccaro

David A Bennett

Julie A Schneider

Paul K Crane

Angela L Jefferson

Timothy J. Hohman

Affiliated Authors:

Neha S Raghavan

Badri N Vardarajan

Richard Mayeux

Columbia Affiliation:

Subjects:

Alzheimer Disease (MeSH)

Cognitive Dysfunction (MeSH)

Multiple Sclerosis (MeSH)

Mechanisms of Alzheimer's Disease (OpenAlex Topic)

Genomic Studies and Association Analyses (OpenAlex Topic)

Diagnosis and Management of Alzheimer's Disease (OpenAlex Topic)

Author Keywords:

alzheimer's disease

sex differences

resilience

genetics

gwas

alzheimer’s disease

Grants:

K12HD043483 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)

UL1TR000445 (NIH – National Center for Advancing Translational Sciences)

T32GM080178 (NIH – National Institute of General Medical Sciences)

P50MH084051 (NIH – National Institute of Mental Health)

R01MH097276 (NIH – National Institute of Mental Health)

R37MH057881 (NIH – National Institute of Mental Health)

R01MH085542 (NIH – National Institute of Mental Health)

R01MH075916 (NIH – National Institute of Mental Health)

U01MH103392 (NIH – National Institute of Mental Health)

R01MH109677 (NIH – National Institute of Mental Health)

P50MH096891 (NIH – National Institute of Mental Health)

R01MH093725 (NIH – National Institute of Mental Health)

R01MH109897 (NIH – National Institute of Mental Health)

R01MH110921 (NIH – National Institute of Mental Health)

P50MH084053 (NIH – National Institute of Mental Health)

P50MH066392 (NIH – National Institute of Mental Health)

R01NS080820 (NIH – National Institute of Neurological Disorders and Stroke)

R01NS100980 (NIH – National Institute of Neurological Disorders and Stroke)

U24NS072026 (NIH – National Institute of Neurological Disorders and Stroke)

P50AG016574 (NIH – National Institute On Aging)

R01AG059716 (NIH – National Institute On Aging)

R01AG074012 (NIH – National Institute On Aging)

R01AG073439 (NIH – National Institute On Aging)

U01AG046152 (NIH – National Institute On Aging)

P30AG019610 (NIH – National Institute On Aging)

U24AG041689 (NIH – National Institute On Aging)

R13AG030995 (NIH – National Institute On Aging)

U01AG006786 (NIH – National Institute On Aging)

R56AG057191 (NIH – National Institute On Aging)

P30AG072975 (NIH – National Institute On Aging)

R01AG056534 (NIH – National Institute On Aging)

R01AG018023 (NIH – National Institute On Aging)

U01AG032984 (NIH – National Institute On Aging)

K01AG049164 (NIH – National Institute On Aging)

U01AG006781 (NIH – National Institute On Aging)

P30AG010161 (NIH – National Institute On Aging)

R01AG046171 (NIH – National Institute On Aging)

P50AG005136 (NIH – National Institute On Aging)

R00AG061238 (NIH – National Institute On Aging)

RF1AG051550 (NIH – National Institute On Aging)

R01AG032990 (NIH – National Institute On Aging)

P30AG066509 (NIH – National Institute On Aging)

U01AG046139 (NIH – National Institute On Aging)

P01AG017216 (NIH – National Institute On Aging)

R21AG059941 (NIH – National Institute On Aging)

R01AG057914 (NIH – National Institute On Aging)

R01AG034962 (NIH – National Institute On Aging)

R01AG061518 (NIH – National Institute On Aging)

U24AG074855 (NIH – National Institute On Aging)

U01AG061356 (NIH – National Institute On Aging)

K23AG062750 (NIH – National Institute On Aging)

R01AG015819 (NIH – National Institute On Aging)

U01AG068057 (NIH – National Institute On Aging)

U01AG024904 (NIH – National Institute On Aging)

U19AG066567 (NIH – National Institute On Aging)

P20AG068082 (NIH – National Institute On Aging)

K24AG046373 (NIH – National Institute On Aging)

R01AG017917 (NIH – National Institute On Aging)

F31AG051381 (NIH – National Institute On Aging)

P01AG002219 (NIH – National Institute On Aging)

S10OD023680 (NIH – Office of the Director, National Institutes of Health)

Publication Type:

Article

Unique ID:

10.1093/brain/awac177

PMID:

35552371

DOI:

10.1093/brain/awac177

Journal:

Brain

Publication Date:

2022-07-01

Data Source:

Scopus

Source Link:

View Scopus Record

View OpenAlex Record

View PubMed Record

View Web of Science Record

Record Created:

Thursday, December 19, 2024 - 08:49