Yarchoan, M., Powderly, J. D., Bastos, B. R., Karasic, T. B., Crysler, O. V., Munster, P. N., McKean, M. A., Emens, L. A., Saenger, Y. M., Ged, Y., Stagg, R., Smith, S., Whiting, C. C., Moon, A., Prasit, P., Jenkins, Y., Standifer, N., Dubensky, T. W., Whiting, S. H., & Ulahannan, S. V. (2024). First-in-human Phase I Trial of TPST-1120, an Inhibitor of PPARα, as Monotherapy or in Combination with Nivolumab, in Patients with Advanced Solid Tumors. Cancer Research Communications, 4(4), 1100–1110. https://doi.org/10.1158/2767-9764.crc-24-0082

Tzaridis, T., & Wechsler-Reya, R. J. (2024). Just a spoonful of metformin helps the medicine go down. Journal of Clinical Investigation, 134(6). https://doi.org/10.1172/jci179144

Barbera, M., Lehtisalo, J., Perera, D., Aspö, M., Cross, M., De Jager Loots, C. A., Falaschetti, E., Friel, N., Luchsinger, J. A., Gavelin, H. M., Peltonen, M., Price, G., Neely, A. S., Thunborg, C., Tuomilehto, J., Mangialasche, F., Middleton, L., Ngandu, T., … Solomon, A. (2024). A multimodal precision-prevention approach combining lifestyle intervention with metformin repurposing to prevent cognitive impairment and disability: the MET-FINGER randomised controlled trial protocol. Alzheimer’s Research & Therapy, 16(1). https://doi.org/10.1186/s13195-023-01355-x

Rasouli, N., Younes, N., Ghosh, A., Albu, J., Cohen, R. M., DeFronzo, R. A., Diaz, E., Sayyed Kassem, L., Luchsinger, J. A., McGill, J. B., Sivitz, W. I., Tamborlane, W. V., Utzschneider, K. M., Kahn, S. E., Crandall, J. P., McKee, M. D., Behringer-Massera, S., Brown-Friday, J., … Xhori, E. (2024). Longitudinal Effects of Glucose-Lowering Medications on β-Cell Responses and Insulin Sensitivity in Type 2 Diabetes: The GRADE Randomized Clinical Trial. Diabetes Care, 47(4), 580–588. https://doi.org/10.2337/dc23-1070

Rothberg, A., Lean, M., & Laferrère, B. (2024). Remission of type 2 diabetes: always more questions, but enough answers for action. Diabetologia, 67(4), 602–610. https://doi.org/10.1007/s00125-023-06069-1

Goodwin, P. J., Chen, B. E., Gelmon, K. A., Whelan, T. J., Ennis, M., Lemieux, J., Ligibel, J. A., Hershman, D. L., Mayer, I. A., Hobday, T. J., Bliss, J. M., Rastogi, P., Rabaglio-Poretti, M., Thompson, A. M., Rea, D. W., Stos, P. M., Shepherd, L. E., Stambolic, V., & Parulekar, W. R. (2023). Effect of Metformin Versus Placebo on New Primary Cancers in Canadian Cancer Trials Group MA.32: A Secondary Analysis of a Phase III Randomized Double-Blind Trial in Early Breast Cancer. Journal of Clinical Oncology, 41(35), 5356–5362. https://doi.org/10.1200/jco.23.00296

Park, J., Hall, C., Hubbard, B., LaMoia, T., Gaspar, R., Nasiri, A., Li, F., Zhang, H., Kim, J., Haeusler, R. A., Accili, D., Shulman, G. I., Yu, H., & Choi, E. (2023). MAD2-Dependent Insulin Receptor Endocytosis Regulates Metabolic Homeostasis. Diabetes, 72(12), 1781–1794. https://doi.org/10.2337/db23-0314

Khera, R., Dhingra, L. S., Aminorroaya, A., Li, K., Zhou, J. J., Arshad, F., Blacketer, C., Bowring, M. G., Bu, F., Cook, M., Dorr, D. A., Duarte-Salles, T., DuVall, S. L., Falconer, T., French, T. E., Hanchrow, E. E., Horban, S., Lau, W. C., Li, J., … Suchard, M. A. (2023). Multinational patterns of second line antihyperglycaemic drug initiation across cardiovascular risk groups: federated pharmacoepidemiological evaluation in LEGEND-T2DM. BMJ Medicine, 2(1), e000651. https://doi.org/10.1136/bmjmed-2023-000651

Stamatiades, G. A., D’Silva, P., Elahee, M., Viana, G. M., Sideri-Gugger, A., & Majumdar, S. K. (2023). Diabetic Ketoacidosis Associated with Sodium-Glucose Cotransporter 2 Inhibitors: Clinical and Biochemical Characteristics of 29 Cases. International Journal of Endocrinology, 2023, 1–7. https://doi.org/10.1155/2023/6615624

Sun, X., Zhang, Q., Kadier, K., Hu, P., Liu, X., Liu, J., Yan, Y., Sun, C., Yau, V., Lowe, S., Meng, M., Liu, Z., & Zhou, M. (2023). Association between diabetes status and breast cancer in US adults: findings from the US National Health and Nutrition Examination Survey. Frontiers in Endocrinology, 14. https://doi.org/10.3389/fendo.2023.1059303

Tayebi, N., Leon‐Ricardo, B., McCall, K., Mehinovic, E., Engelstad, K., Huynh, V., Turner, T. N., Weisenberg, J., Thio, L. L., Hruz, P., Williams, R. S. B., De Vivo, D. C., Petit, V., Haller, G., & Gurnett, C. A. (2023). Quantitative determination of SLC2A1 variant functional effects in GLUT1 deficiency syndrome. Annals of Clinical and Translational Neurology, 10(5), 787–801. Portico. https://doi.org/10.1002/acn3.51767

Garcia, J. A., Chen, R., Xu, M., Comerford, S. A., Hammer, R. E., Melton, S. D., & Feagins, L. A. (2023). Acss2/HIF-2 signaling facilitates colon cancer growth and metastasis. PLOS ONE, 18(3), e0282223. https://doi.org/10.1371/journal.pone.0282223

González, B. J., Zhao, H., Niu, J., Williams, D. J., Lee, J., Goulbourne, C. N., Xing, Y., Wang, Y., Oberholzer, J., Blumenkrantz, M. H., Chen, X., LeDuc, C. A., Chung, W. K., Colecraft, H. M., Gromada, J., Shen, Y., Goland, R. S., Leibel, R. L., & Egli, D. (2022). Reduced calcium levels and accumulation of abnormal insulin granules in stem cell models of HNF1A deficiency. Communications Biology, 5(1). https://doi.org/10.1038/s42003-022-03696-z

Wang, Y., Spolitu, S., Zadroga, J. A., Sarecha, A. K., & Ozcan, L. (2022). Hepatocyte Rap1a contributes to obesity- and statin-associated hyperglycemia. Cell Reports, 40(8), 111259. https://doi.org/10.1016/j.celrep.2022.111259

Aroda, V. R., Krause-Steinrauf, H., Kazemi, E. J., Buse, J. B., Gulanski, B. I., Florez, H. J., Ahmann, A. J., Loveland, A., Kuhn, A., Lonier, J. Y., Wexler, D. J., Crandall, J. P., McKee, M. D., Behringer-Massera, S., Brown-Friday, J., Xhori, E., Ballentine-Cargill, K., Duran, S., … Behringer-Massera, S. (2022). Clinical and Metabolic Characterization of Adults With Type 2 Diabetes by Age in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) Cohort. Diabetes Care, 45(7), 1512–1521. https://doi.org/10.2337/dc21-2659

Goodwin, P. J., Chen, B. E., Gelmon, K. A., Whelan, T. J., Ennis, M., Lemieux, J., Ligibel, J. A., Hershman, D. L., Mayer, I. A., Hobday, T. J., Bliss, J. M., Rastogi, P., Rabaglio-Poretti, M., Mukherjee, S. D., Mackey, J. R., Abramson, V. G., Oja, C., Wesolowski, R., Thompson, A. M., … Parulekar, W. R. (2022). Effect of Metformin vs Placebo on Invasive Disease–Free Survival in Patients With Breast Cancer. JAMA, 327(20), 1963. https://doi.org/10.1001/jama.2022.6147

Bartolomé, A., Suda, N., Yu, J., Zhu, C., Son, J., Ding, H., Califano, A., Accili, D., & Pajvani, U. B. (2022). Notch-mediated Ephrin signaling disrupts islet architecture and β cell function. JCI Insight, 7(6). https://doi.org/10.1172/jci.insight.157694