Targeting ryanodine receptors with allopurinol and xanthine derivatives for the treatment of cardiac and musculoskeletal weakness disorders

Miotto, M. C., Luna-Figueroa, E., Tchagou, C., Bahlouli, L., Reiken, S., Dridi, H., Liu, Y., Weninger, G., & Marks, A. R. (2025). Targeting ryanodine receptors with allopurinol and xanthine derivatives for the treatment of cardiac and musculoskeletal weakness disorders. Proceedings of the National Academy of Sciences, 122(24). https://doi.org/10.1073/pnas.2422082122
Authors:
Marco C Miotto
Estefania Luna-Figueroa
Carl Tchagou
Laith Bahlouli
Steven Reiken
Haikel Dridi
Yang Liu
Gunnar Weninger
Andrew R Marks
Affiliated Authors:
Marco C Miotto
Estefania Luna-Figueroa
Carl Tchagou
Laith Bahlouli
Steven Reiken
Haikel Dridi
Yang Liu
Gunnar Weninger
Andrew R Marks
Columbia Affiliation:
Subjects:
Aetiology, Diagnosis, and Management of Myocarditis (OpenAlex Topic)
Uric Acid in Cardiovascular and Renal Health (OpenAlex Topic)
Epidemiology and Treatment of Chagas Disease (OpenAlex Topic)
Ryanodine Receptor Calcium Release Channel (MeSH)
Allopurinol (MeSH)
Xanthine (MeSH)
Muscle Weakness (MeSH)
Xanthines (MeSH)
Author Keywords:
allopurinol
calcium sensitizing
cardiac and muscle weakness
ryanodine receptor
xanthine derivatives
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Publication Type:
Article
Unique ID:
10.1073/pnas.2422082122
PMID:
40512792
DOI:
10.1073/pnas.2422082122
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Publication Date:
Data Source:
PubMed
Source Link:
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Record Created: