A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients

Pita-Juarez, Y., Karagkouni, D., Kalavros, N., Melms, J. C., Niezen, S., Delorey, T. M., Essene, A. L., Brook, O. R., Pant, D., Skelton-Badlani, D., Naderi, P., Huang, P., Pan, L., Hether, T., Andrews, T. S., Ziegler, C. G. K., Reeves, J., Myloserdnyy, A., Chen, R., … Vlachos, I. S. (2025). A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients. Genome Biology, 26(1). https://doi.org/10.1186/s13059-025-03499-5
Authors:
Yered Pita-Juarez
Dimitra Karagkouni
Nikolaos Kalavros
Johannes C Melms
Sebastian Niezen
Toni M Delorey
Adam L Essene
Olga R Brook
Deepti Pant
Disha Skelton-Badlani
Pourya Naderi
Pinzhu Huang
Liuliu Pan
Tyler Hether
Tallulah S Andrews
Carly G K Ziegler
Jason Reeves
Andriy Myloserdnyy
Rachel Chen
Andy Nam
Stefan Phelan
Yan Liang
Mark Gregory
Shanshan He
Michael Patrick
Tushar Rane
Aster Wardhani
Amit Dipak Amin
Jana Biermann
Hanina Hibshoosh
Molly Veregge
Zachary Kramer
Christopher Jacobs
Yusuf Yalcin
Devan Phillips
Michal Slyper
Ayshwarya Subramanian
Orr Ashenberg
Zohar Bloom-Ackermann
Victoria M Tran
James Gomez
Alexander Sturm
Shuting Zhang
Stephen J Fleming
Sarah Warren
Joseph Beechem
Deborah Hung
Mehrtash Babadi
Robert F Padera
Sonya A MacParland
Gary D Bader
Nasser Imad
Isaac H Solomon
Eric Miller
Stefan Riedel
Caroline B M Porter
Alexandra-Chloé Villani
Linus T-Y Tsai
Winston Hide
Gyongyi Szabo
Jonathan Hecht
Orit Rozenblatt-Rosen
Alex K Shalek
Benjamin Izar
Aviv Regev
Yury V Popov
Z Gordon Jiang
Ioannis S Vlachos
Affiliated Authors:
Johannes C Melms
Amit Dipak Amin
Jana Biermann
Hanina Hibshoosh
Benjamin Izar
Columbia Affiliation:
Subjects:
Comprehensive Integration of Single-Cell Transcriptomic Data (OpenAlex Topic)
Genetics and Pathogenesis of Type 1 Diabetes (OpenAlex Topic)
Epidemiology and Management of NAFLD (OpenAlex Topic)
COVID-19 (MeSH)
Liver (MeSH)
Transcriptome (MeSH)
SARS-CoV-2 (MeSH)
Author Keywords:
sars-cov-2
covid-19
spatial transcriptomics
single-nucleus sequencing
liver
single-cell sequencing
elink
Publication Type:
Article
Unique ID:
10.1186/s13059-025-03499-5
PMID:
40087773
DOI:
10.1186/s13059-025-03499-5
Journal:
Genome Biology
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View OpenAlex Record
View Web of Science Record

Record Created: