PLOS Pathogens

Displaying 1 - 14 of 14
Rawat, M., Padalino, G., Adika, E., Okombo, J., Yeo, T., Brancale, A., Fidock, D. A., Hoffmann, K. F., & Lee, M. C. S. (2025). Quinoxaline-based anti-schistosomal compounds have potent anti-plasmodial activity. PLOS Pathogens, 21(2), e1012216. https://doi.org/10.1371/journal.ppat.1012216
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Xie, S. C., Tai, C.-W., Morton, C. J., Ma, L., Huang, S.-C., Wittlin, S., Du, Y., Hu, Y., Dogovski, C., Salimimarand, M., Griffin, R., England, D., de la Cruz, E., Deni, I., Yeo, T., Burkhard, A. Y., Striepen, J., Schindler, K. A., Crespo, B., … Tilley, L. (2024). A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo. PLOS Pathogens, 20(12), e1012429. https://doi.org/10.1371/journal.ppat.1012429
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Ferreira, L. T., Cassiano, G. C., Alvarez, L. C. S., Okombo, J., Calit, J., Fontinha, D., Gil-Iturbe, E., Coyle, R., Andrade, C. H., Sunnerhagen, P., Bargieri, D. Y., Prudêncio, M., Quick, M., Cravo, P. V., Lee, M. C. S., Fidock, D. A., & Costa, F. T. M. (2024). A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants. PLOS Pathogens, 20(10), e1012627. https://doi.org/10.1371/journal.ppat.1012627
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Bobba, S., Chauhan, K. S., Akter, S., Das, S., Mittal, E., Mathema, B., Philips, J. A., & Khader, S. A. (2024). A protective role for type I interferon signaling following infection with Mycobacterium tuberculosis carrying the rifampicin drug resistance-conferring RpoB mutation H445Y. PLOS Pathogens, 20(4), e1012137. https://doi.org/10.1371/journal.ppat.1012137
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Joseph, S. B., Abrahams, M.-R., Moeser, M., Tyers, L., Archin, N. M., Council, O. D., Sondgeroth, A., Spielvogel, E., Emery, A., Zhou, S., Doolabh, D., Ismail, S. D., Karim, S. A., Margolis, D. M., Pond, S. K., Garrett, N., Swanstrom, R., & Williamson, C. (2024). The timing of HIV-1 infection of cells that persist on therapy is not strongly influenced by replication competency or cellular tropism of the provirus. PLOS Pathogens, 20(2), e1011974. https://doi.org/10.1371/journal.ppat.1011974
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Berton, R. R., McGonagil, P. W., Jensen, I. J., Ybarra, T. K., Bishop, G. A., Harty, J. T., Griffith, T. S., & Badovinac, V. P. (2023). Sepsis leads to lasting changes in phenotype and function of naïve CD8 T cells. PLOS Pathogens, 19(10), e1011720. https://doi.org/10.1371/journal.ppat.1011720
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Ou, L., Chen, S. J., Teng, I.-T., Yang, L., Zhang, B., Zhou, T., Biju, A., Cheng, C., Kong, W.-P., Morano, N. C., Stancofski, E.-S. D., Todd, J.-P., Tsybovsky, Y., Wang, S., Zheng, C.-Y., Mascola, J. R., Shapiro, L., Woodward, R. A., Buchholz, U. J., & Kwong, P. D. (2023). Structure-based design of a single-chain triple-disulfide-stabilized fusion-glycoprotein trimer that elicits high-titer neutralizing responses against human metapneumovirus. PLOS Pathogens, 19(9), e1011584. https://doi.org/10.1371/journal.ppat.1011584
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Maximova, O. A., Weller, M. L., Krogmann, T., Sturdevant, D. E., Ricklefs, S., Virtaneva, K., Martens, C., Wollenberg, K., Minai, M., Moore, I. N., Sauter, C. S., Barker, J. N., Lipkin, W. I., Seilhean, D., Nath, A., & Cohen, J. I. (2023). Pathogenesis and outcome of VA1 astrovirus infection in the human brain are defined by disruption of neural functions and imbalanced host immune responses. PLOS Pathogens, 19(8), e1011544. https://doi.org/10.1371/journal.ppat.1011544
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Kucharski, M., Wirjanata, G., Nayak, S., Boentoro, J., Dziekan, J. M., Assisi, C., van der Pluijm, R. W., Miotto, O., Mok, S., Dondorp, A. M., & Bozdech, Z. (2023). Short tandem repeat polymorphism in the promoter region of cyclophilin 19B drives its transcriptional upregulation and contributes to drug resistance in the malaria parasite Plasmodium falciparum. PLOS Pathogens, 19(1), e1011118. https://doi.org/10.1371/journal.ppat.1011118
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Zhang, B., Huang, W., Pei, S., Zeng, J., Shen, W., Wang, D., Wang, G., Chen, T., Yang, L., Cheng, P., Wang, D., Shu, Y., & Du, X. (2022). Mechanisms for the circulation of influenza A(H3N2) in China: A spatiotemporal modelling study. PLOS Pathogens, 18(12), e1011046. https://doi.org/10.1371/journal.ppat.1011046
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Okombo, J., Mok, S., Qahash, T., Yeo, T., Bath, J., Orchard, L. M., Owens, E., Koo, I., Albert, I., Llinás, M., & Fidock, D. A. (2022). Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages. PLOS Pathogens, 18(10), e1010926. https://doi.org/10.1371/journal.ppat.1010926
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Morris, S. E., Strehlau, R., Shiau, S., Abrams, E. J., Tiemessen, C. T., Kuhn, L., & Yates, A. J. (2022). Healthy dynamics of CD4 T cells may drive HIV resurgence in perinatally-infected infants on antiretroviral therapy. PLOS Pathogens, 18(8), e1010751. https://doi.org/10.1371/journal.ppat.1010751
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Palrasu, M., Zaika, E., Paulrasu, K., Caspa Gokulan, R., Suarez, G., Que, J., El-Rifai, W., Peek, R. M., Garcia-Buitrago, M., & Zaika, A. I. (2022). Helicobacter pylori pathogen inhibits cellular responses to oncogenic stress and apoptosis. PLOS Pathogens, 18(6), e1010628. https://doi.org/10.1371/journal.ppat.1010628
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Small-Saunders, J. L., Hagenah, L. M., Wicht, K. J., Dhingra, S. K., Deni, I., Kim, J., Vendome, J., Gil-Iturbe, E., Roepe, P. D., Mehta, M., Mancia, F., Quick, M., Eppstein, M. J., & Fidock, D. A. (2022). Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance. PLOS Pathogens, 18(2), e1010278. https://doi.org/10.1371/journal.ppat.1010278
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