Molecular Psychiatry
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Di Re, J., Marini, M., Hussain, S. I., Singh, A. K., Venkatesh, A., Alshammari, M. A., Alshammari, T. K., Hamoud, A.-R. A., Imami, A. S., Haghighijoo, Z., Fularcyzk, N., Stertz, L., Hawes, D., Mosebarger, A., Jernigan, J., Chaljub, C., Nehme, R., Walss-Bass, C., Schulmann, A., … Laezza, F. (2025). βIV spectrin abundancy, cellular distribution and sensitivity to AKT/GSK3 regulation in schizophrenia. Molecular Psychiatry. https://doi.org/10.1038/s41380-025-02917-1
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Kildegaard, H., Bliddal, M., Ernst, M. T., Sander, S. D., Wesselhoeft, R., Gingrich, J. A., Pottegård, A., Margolis, K. G., & Talati, A. (2024). Prenatal exposure to selective serotonin reuptake inhibitors and risk of disorders of gut-brain interaction in children. Molecular Psychiatry. https://doi.org/10.1038/s41380-024-02848-3
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Le Borgne, J., Gomez, L., Heikkinen, S., Amin, N., Ahmad, S., Choi, S. H., Bis, J., Grenier-Boley, B., Rodriguez, O. G., Kleineidam, L., Young, J., Tripathi, K. P., Wang, L., Varma, A., Campos-Martin, R., van der Lee, S., Damotte, V., de Rojas, I., Palmal, S., … Bellenguez, C. (2024). X‐chromosome-wide association study for Alzheimer’s disease. Molecular Psychiatry. https://doi.org/10.1038/s41380-024-02838-5
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Goldstein, J. M., Konishi, K., Aroner, S., Lee, H., Remington, A., Chitnis, T., Buka, S. L., Hornig, M., & Tobet, S. A. (2024). Prenatal immune origins of brain aging differ by sex. Molecular Psychiatry. https://doi.org/10.1038/s41380-024-02798-w
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Airagnes, G., Sánchez-Rico, M., Deguilhem, A., Blanco, C., Olfson, M., Ouazana Vedrines, C., Lemogne, C., Limosin, F., & Hoertel, N. (2024). Nicotine dependence and incident psychiatric disorders: prospective evidence from US national study. Molecular Psychiatry. https://doi.org/10.1038/s41380-024-02748-6
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Oquendo, M. A., Galfalvy, H. C., Choo, T.-H., Herzog, S., Burke, A. K., Sublette, M. E., Mann, J. J., & Stanley, B. H. (2024). Occurrence and characteristics of suicidal ideation in psychiatrically healthy individuals based on ecological momentary assessment. Molecular Psychiatry. https://doi.org/10.1038/s41380-024-02560-2
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Sun, S., Liu, Q., Wang, Z., Huang, Y., Sublette, M. E., Dwork, A. J., Rosoklija, G., Ge, Y., Galfalvy, H., Mann, J. J., & Haghighi, F. (2024). Brain and blood transcriptome profiles delineate common genetic pathways across suicidal ideation and suicide. Molecular Psychiatry, 29(5), 1417–1426. https://doi.org/10.1038/s41380-024-02420-z
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Zambon, A., Rico, L. C., Herman, M., Gundacker, A., Telalovic, A., Hartenberger, L.-M., Kuehn, R., Romanov, R. A., Hussaini, S. A., Harkany, T., & Pollak, D. D. (2022). Gestational immune activation disrupts hypothalamic neurocircuits of maternal care behavior. Molecular Psychiatry, 29(4), 859–873. https://doi.org/10.1038/s41380-022-01602-x
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Rubio, J. M., Lencz, T., Cao, H., Kraguljac, N., Dhamala, E., Homan, P., Horga, G., Sarpal, D. K., Argyelan, M., Gallego, J., Cholewa, J., Barber, A., Kane, J. M., & Malhotra, A. K. (2024). Replication of a neuroimaging biomarker for striatal dysfunction in psychosis. Molecular Psychiatry, 29(4), 929–938. https://doi.org/10.1038/s41380-023-02381-9
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Kim, B.-G., Kim, G., Abe, Y., Alonso, P., Ameis, S., Anticevic, A., Arnold, P. D., Balachander, S., Banaj, N., Bargalló, N., Batistuzzo, M. C., Benedetti, F., Bertolín, S., Beucke, J. C., Bollettini, I., Brem, S., Brennan, B. P., Buitelaar, J. K., … Calvo, R. (2024). White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group. Molecular Psychiatry, 29(4), 1063–1074. https://doi.org/10.1038/s41380-023-02392-6
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Vriend, C., de Joode, N. T., Pouwels, P. J. W., Liu, F., Otaduy, M. C. G., Pastorello, B., Robertson, F. C., Ipser, J., Lee, S., Hezel, D. M., van Meter, P. E., Batistuzzo, M. C., Hoexter, M. Q., Sheshachala, K., Narayanaswamy, J. C., Venkatasubramanian, G., Lochner, C., Miguel, E. C., Reddy, Y. C. J., … van den Heuvel, O. A. (2024). Age of onset of obsessive-compulsive disorder differentially affects white matter microstructure. Molecular Psychiatry, 29(4), 1033–1045. https://doi.org/10.1038/s41380-023-02390-8
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Su, P., Yan, S., Chen, K., Huang, L., Wang, L., Lee, F. H. F., Zhou, H., Lai, T. K. Y., Jiang, A., Samsom, J., Wong, A. H. C., Yang, G., & Liu, F. (2024). EF1α-associated protein complexes affect dendritic spine plasticity by regulating microglial phagocytosis in Fmr1 knock-out mice. Molecular Psychiatry, 29(4), 1099–1113. https://doi.org/10.1038/s41380-023-02396-2
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Huggins, A. A., Baird, C. L., Briggs, M., Laskowitz, S., Hussain, A., Fouda, S., Haswell, C., Sun, D., Salminen, L. E., Jahanshad, N., Thomopoulos, S. I., Veltman, D. J., Frijling, J. L., Olff, M., van Zuiden, M., Koch, S. B. J., Nawjin, L., Wang, L., Zhu, Y., … Morey, R. (2024). Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup. Molecular Psychiatry, 29(3), 611–623. https://doi.org/10.1038/s41380-023-02352-0
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Li, C., Stebbins, R. C., Noppert, G. A., Carney, C. X., Liu, C., Sapp, A. R. M., Watson, E. J., & Aiello, A. E. (2023). Peripheral immune function and Alzheimer’s disease: a living systematic review and critical appraisal. Molecular Psychiatry, 29(6), 1895–1905. https://doi.org/10.1038/s41380-023-02355-x
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Kirshenbaum, G. S., Chang, C.-Y., Bompolaki, M., Bradford, V. R., Bell, J., Kosmidis, S., Shansky, R. M., Orlandi, J., Savage, L. M., Harris, A. Z., David Leonardo, E., & Dranovsky, A. (2023). Adult-born neurons maintain hippocampal cholinergic inputs and support working memory during aging. Molecular Psychiatry, 28(12), 5337–5349. https://doi.org/10.1038/s41380-023-02167-z
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Sha, Q., Fu, Z., Escobar Galvis, M. L., Madaj, Z., Underwood, M. D., Steiner, J. A., Dwork, A., Simpson, N., Galfalvy, H., Rozoklija, G., Achtyes, E. D., Mann, J. J., & Brundin, L. (2023). Integrative transcriptome- and DNA methylation analysis of brain tissue from the temporal pole in suicide decedents and their controls. Molecular Psychiatry, 29(1), 134–145. https://doi.org/10.1038/s41380-023-02311-9
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Wootton, O., Shadrin, A. A., Mohn, C., Susser, E., Ramesar, R., Gur, R. C., Andreassen, O. A., Stein, D. J., & Dalvie, S. (2023). Genome-wide association study in 404,302 individuals identifies 7 significant loci for reaction time variability. Molecular Psychiatry, 28(9), 4011–4019. https://doi.org/10.1038/s41380-023-02292-9
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Kim, H., Zhu, X., Zhao, Y., Bell, S. A., Gehrman, P. R., Cohen, D., Devanand, D. P., Goldberg, T. E., & Lee, S. (2023). Resting-state functional connectivity changes in older adults with sleep disturbance and the role of amyloid burden. Molecular Psychiatry, 28(10), 4399–4406. https://doi.org/10.1038/s41380-023-02214-9
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Bruin, W. B., Abe, Y., Alonso, P., Anticevic, A., Backhausen, L. L., Balachander, S., Bargallo, N., Batistuzzo, M. C., Benedetti, F., Bertolin Triquell, S., Brem, S., Calesella, F., Couto, B., Denys, D. A. J. P., Echevarria, M. A. N., Eng, G. K., Ferreira, S., Feusner, J. D., … Grazioplene, R. G. (2023). The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium. Molecular Psychiatry, 28(10), 4307–4319. https://doi.org/10.1038/s41380-023-02077-0
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Zhang, Y., Shen, Y., Liufu, N., Liu, L., Li, W., Shi, Z., Zheng, H., Mei, X., Chen, C.-Y., Jiang, Z., Abtahi, S., Dong, Y., Liang, F., Shi, Y., Cheng, L. L., Yang, G., Kang, J. X., Wilkinson, J. E., & Xie, Z. (2023). Transmission of Alzheimer’s disease-associated microbiota dysbiosis and its impact on cognitive function: evidence from mice and patients. Molecular Psychiatry, 28(10), 4421–4437. https://doi.org/10.1038/s41380-023-02216-7
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Suri, D., Zanni, G., Mahadevia, D., Chuhma, N., Saha, R., Spivack, S., Pini, N., Stevens, G. S., Ziolkowski-Blake, A., Simpson, E. H., Balsam, P., Rayport, S., & Ansorge, M. S. (2023). Dopamine transporter blockade during adolescence increases adult dopamine function, impulsivity, and aggression. Molecular Psychiatry, 28(8), 3512–3523. https://doi.org/10.1038/s41380-023-02194-w
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Pagliaccio, D., Wengler, K., Durham, K., Fontaine, M., Rueppel, M., Becker, H., Bilek, E., Pieper, S., Risdon, C., Horga, G., Fitzgerald, K. D., & Marsh, R. (2023). Probing midbrain dopamine function in pediatric obsessive-compulsive disorder via neuromelanin-sensitive magnetic resonance imaging. Molecular Psychiatry, 28(7), 3075–3082. https://doi.org/10.1038/s41380-023-02105-z
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Che, X., Roy, A., Bresnahan, M., Mjaaland, S., Reichborn-Kjennerud, T., Magnus, P., Stoltenberg, C., Shang, Y., Zhang, K., Susser, E., Fiehn, O., & Lipkin, W. I. (2023). Metabolomic analysis of maternal mid-gestation plasma and cord blood in autism spectrum disorders. Molecular Psychiatry, 28(6), 2355–2369. https://doi.org/10.1038/s41380-023-02051-w
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Department of Biostatistics; Vagelos College of Physicians and Surgeons; Department of Psychiatry; Division of Child and Adolescent Psychiatry; Center for Infection and Immunity; Mailman School of Public Health; Department of Epidemiology; Department of Neurology; Department of Pathology and Cell Biology
Zhang, J., Raya, J., Morfini, F., Urban, Z., Pagliaccio, D., Yendiki, A., Auerbach, R. P., Bauer, C. C. C., & Whitfield-Gabrieli, S. (2023). Reducing default mode network connectivity with mindfulness-based fMRI neurofeedback: a pilot study among adolescents with affective disorder history. Molecular Psychiatry, 28(6), 2540–2548. https://doi.org/10.1038/s41380-023-02032-z
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Schultebraucks, K., Blekic, W., Basaraba, C., Corbeil, T., Khan, Z., Henry, B. F., Krawczyk, N., Rivera, B. D., Allen, B., Arout, C., Pincus, H. A., Martinez, D. M., & Levin, F. R. (2023). The impact of preexisting psychiatric disorders and antidepressant use on COVID-19 related outcomes: a multicenter study. Molecular Psychiatry, 28(6), 2462–2468. https://doi.org/10.1038/s41380-023-02049-4
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Jobin, M.-L., De Smedt-Peyrusse, V., Ducrocq, F., Baccouch, R., Oummadi, A., Pedersen, M. H., Medel-Lacruz, B., Angelo, M.-F., Villette, S., Van Delft, P., Fouillen, L., Mongrand, S., Selent, J., Tolentino-Cortez, T., Barreda-Gómez, G., Grégoire, S., Masson, E., Durroux, T., Javitch, J. A., … Trifilieff, P. (2023). Impact of membrane lipid polyunsaturation on dopamine D2 receptor ligand binding and signaling. Molecular Psychiatry, 28(5), 1960–1969. https://doi.org/10.1038/s41380-022-01928-6
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Merritt, K., McCutcheon, R. A., Aleman, A., Ashley, S., Beck, K., Block, W., Bloemen, O. J. N., Borgan, F., Boules, C., Bustillo, J. R., Capizzano, A. A., Coughlin, J. M., David, A., de la Fuente-Sandoval, C., Demjaha, A., Dempster, K., Do, K. Q., Du, F., Falkai, P., … McGuire, P. K. (2023). Variability and magnitude of brain glutamate levels in schizophrenia: a meta and mega-analysis. Molecular Psychiatry, 28(5), 2039–2048. https://doi.org/10.1038/s41380-023-01991-7
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Groenewold, N. A., Bas-Hoogendam, J. M., Amod, A. R., Laansma, M. A., Van Velzen, L. S., Aghajani, M., Hilbert, K., Oh, H., Salas, R., Jackowski, A. P., Pan, P. M., Salum, G. A., Blair, J. R., Blair, K. S., Hirsch, J., Pantazatos, S. P., Schneier, F. R., Talati, A., Roelofs, K., … Van der Wee, N. J. A. (2023). Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group. Molecular Psychiatry, 28(3), 1079–1089. https://doi.org/10.1038/s41380-022-01933-9
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Palmer, E. E., Pusch, M., Picollo, A., Forwood, C., Nguyen, M. H., Suckow, V., Gibbons, J., Hoff, A., Sigfrid, L., Megarbane, A., Nizon, M., Cogné, B., Beneteau, C., Alkuraya, F. S., Chedrawi, A., Hashem, M. O., Stamberger, H., Weckhuysen, S., Vanlander, A., … Kalscheuer, V. M. (2022). Functional and clinical studies reveal pathophysiological complexity of CLCN4-related neurodevelopmental condition. Molecular Psychiatry, 28(2), 668–697. https://doi.org/10.1038/s41380-022-01852-9
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Kyzar, E. J., & Denfield, G. H. (2022). Taking subjectivity seriously: towards a unification of phenomenology, psychiatry, and neuroscience. Molecular Psychiatry, 28(1), 10–16. https://doi.org/10.1038/s41380-022-01891-2
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Zoghbi, A. W., Lieberman, J. A., & Girgis, R. R. (2022). The neurobiology of duration of untreated psychosis: a comprehensive review. Molecular Psychiatry, 28(1), 168–190. https://doi.org/10.1038/s41380-022-01718-0
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Maihofer, A. X., Engchuan, W., Huguet, G., Klein, M., MacDonald, J. R., Shanta, O., Thiruvahindrapuram, B., Jean-louis, M., Saci, Z., Jacquemont, S., Scherer, S. W., Ketema, E., Aiello, A. E., Amstadter, A. B., Avdibegović, E., Babic, D., Baker, D. G., Bisson, J. I., Boks, M. P., … Nievergelt, C. M. (2022). Rare copy number variation in posttraumatic stress disorder. Molecular Psychiatry, 27(12), 5062–5069. https://doi.org/10.1038/s41380-022-01776-4
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Lahti, J., Tuominen, S., Yang, Q., Pergola, G., Ahmad, S., Amin, N., Armstrong, N. J., Beiser, A., Bey, K., Bis, J. C., Boerwinkle, E., Bressler, J., Campbell, A., Campbell, H., Chen, Q., Corley, J., Cox, S. R., Davies, G., De Jager, P. L., … Räikkönen, K. (2022). Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning. Molecular Psychiatry, 27(11), 4419–4431. https://doi.org/10.1038/s41380-022-01710-8
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Rayan, N. A., Kumar, V., Aow, J., Rastegar, N., Lim, M. G. L., O’Toole, N., Aliwarga, E., Arcego, D. M., Yeo, H. T. G., Wong, J. Y., Lee, M. Y., Schmidt, F., Haja, H. S., Tam, W. L., Zhang, T.-Y., Diorio, J., Anacker, C., Hen, R., Parent, C., … Prabhakar, S. (2022). Integrative multi-omics landscape of fluoxetine action across 27 brain regions reveals global increase in energy metabolism and region-specific chromatin remodelling. Molecular Psychiatry, 27(11), 4510–4525. https://doi.org/10.1038/s41380-022-01725-1
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Pantazatos, S. P., Melhem, N. M., Brent, D. A., Zanderigo, F., Bartlett, E. A., Lesanpezeshki, M., Burke, A., Miller, J. M., & Mann, J. J. (2022). Ventral prefrontal serotonin 1A receptor binding: a neural marker of vulnerability for mood disorder and suicidal behavior? Molecular Psychiatry, 27(10), 4136–4143. https://doi.org/10.1038/s41380-022-01671-y
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Narayan, G. A., Hill, K. R., Wengler, K., He, X., Wang, J., Yang, J., Parsey, R. V., & DeLorenzo, C. (2022). Does the change in glutamate to GABA ratio correlate with change in depression severity? A randomized, double-blind clinical trial. Molecular Psychiatry, 27(9), 3833–3841. https://doi.org/10.1038/s41380-022-01730-4
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Bartlett, E. A., Zanderigo, F., Shieh, D., Miller, J., Hurley, P., Rubin-Falcone, H., Oquendo, M. A., Sublette, M. E., Ogden, R. T., & Mann, J. J. (2022). Serotonin transporter binding in major depressive disorder: impact of serotonin system anatomy. Molecular Psychiatry, 27(8), 3417–3424. https://doi.org/10.1038/s41380-022-01578-8
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Medeiros, G. C., Gould, T. D., Prueitt, W. L., Nanavati, J., Grunebaum, M. F., Farber, N. B., Singh, B., Selvaraj, S., Machado-Vieira, R., Achtyes, E. D., Parikh, S. V., Frye, M. A., Zarate, C. A., & Goes, F. S. (2022). Blood-based biomarkers of antidepressant response to ketamine and esketamine: A systematic review and meta-analysis. Molecular Psychiatry, 27(9), 3658–3669. https://doi.org/10.1038/s41380-022-01652-1
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Tejavibulya, L., Rolison, M., Gao, S., Liang, Q., Peterson, H., Dadashkarimi, J., Farruggia, M. C., Hahn, C. A., Noble, S., Lichenstein, S. D., Pollatou, A., Dufford, A. J., & Scheinost, D. (2022). Predicting the future of neuroimaging predictive models in mental health. Molecular Psychiatry, 27(8), 3129–3137. https://doi.org/10.1038/s41380-022-01635-2
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Haage, V., & De Jager, P. L. (2022). Neuroimmune contributions to Alzheimer’s disease: a focus on human data. Molecular Psychiatry, 27(8), 3164–3181. https://doi.org/10.1038/s41380-022-01637-0
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Kizil, C., Sariya, S., Kim, Y. A., Rajabli, F., Martin, E., Reyes-Dumeyer, D., Vardarajan, B., Maldonado, A., Haines, J. L., Mayeux, R., Jiménez-Velázquez, I. Z., Santa-Maria, I., & Tosto, G. (2022). Admixture Mapping of Alzheimer’s disease in Caribbean Hispanics identifies a new locus on 22q13.1. Molecular Psychiatry, 27(6), 2813–2820. https://doi.org/10.1038/s41380-022-01526-6
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Sher, L. (2022). Suicide in diabetes: an important but underappreciated problem. Molecular Psychiatry, 27(7), 2916–2917. https://doi.org/10.1038/s41380-022-01573-z
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Schultebraucks, K., Ben-Zion, Z., Admon, R., Keynan, J. N., Liberzon, I., Hendler, T., & Shalev, A. Y. (2022). Assessment of early neurocognitive functioning increases the accuracy of predicting chronic PTSD risk. Molecular Psychiatry, 27(4), 2247–2254. https://doi.org/10.1038/s41380-022-01445-6
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Chohan, M. O., Kopelman, J. M., Yueh, H., Fazlali, Z., Greene, N., Harris, A. Z., Balsam, P. D., Leonardo, E. D., Kramer, E. R., Veenstra-VanderWeele, J., & Ahmari, S. E. (2022). Developmental impact of glutamate transporter overexpression on dopaminergic neuron activity and stereotypic behavior. Molecular Psychiatry, 27(3), 1515–1526. https://doi.org/10.1038/s41380-021-01424-3
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Gallo, E. F., Greenwald, J., Yeisley, J., Teboul, E., Martyniuk, K. M., Villarin, J. M., Li, Y., Javitch, J. A., Balsam, P. D., & Kellendonk, C. (2021). Dopamine D2 receptors modulate the cholinergic pause and inhibitory learning. Molecular Psychiatry, 27(3), 1502–1514. https://doi.org/10.1038/s41380-021-01364-y
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Che, X., Hornig, M., Bresnahan, M., Stoltenberg, C., Magnus, P., Surén, P., Mjaaland, S., Reichborn-Kjennerud, T., Susser, E., & Lipkin, W. I. (2022). Maternal mid-gestational and child cord blood immune signatures are strongly associated with offspring risk of ASD. Molecular Psychiatry, 27(3), 1527–1541. https://doi.org/10.1038/s41380-021-01415-4
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Department of Biostatistics; Vagelos College of Physicians and Surgeons; Department of Psychiatry; Division of Child and Adolescent Psychiatry; Center for Infection and Immunity; Mailman School of Public Health; Department of Epidemiology; Department of Neurology; Department of Pathology and Cell Biology
Alkelai, A., Greenbaum, L., Docherty, A. R., Shabalin, A. A., Povysil, G., Malakar, A., Hughes, D., Delaney, S. L., Peabody, E. P., McNamara, J., Gelfman, S., Baugh, E. H., Zoghbi, A. W., Harms, M. B., Hwang, H.-S., Grossman-Jonish, A., Aggarwal, V., Heinzen, E. L., Jobanputra, V., … Goldstein, D. B. (2021). The benefit of diagnostic whole genome sequencing in schizophrenia and other psychotic disorders. Molecular Psychiatry, 27(3), 1435–1447. https://doi.org/10.1038/s41380-021-01383-9
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Blanco, C., Wall, M. M., & Olfson, M. (2021). Data needs and models for the opioid epidemic. Molecular Psychiatry, 27(2), 787–792. https://doi.org/10.1038/s41380-021-01356-y
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Prossin, A., Koch, A., Campbell, P., Laumet, G., Stohler, C. S., Dantzer, R., & Zubieta, J.-K. (2021). Effects of placebo administration on immune mechanisms and relationships with central endogenous opioid neurotransmission. Molecular Psychiatry, 27(2), 831–839. https://doi.org/10.1038/s41380-021-01365-x
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Mateus-Pinheiro, A., Patrício, P., Alves, N. D., Martins-Macedo, J., Caetano, I., Silveira-Rosa, T., Araújo, B., Mateus-Pinheiro, M., Silva-Correia, J., Sardinha, V. M., Loureiro-Campos, E., Rodrigues, A. J., Oliveira, J. F., Bessa, J. M., Sousa, N., & Pinto, L. (2021). Hippocampal cytogenesis abrogation impairs inter-regional communication between the hippocampus and prefrontal cortex and promotes the time-dependent manifestation of emotional and cognitive deficits. Molecular Psychiatry, 26(12), 7154–7166. https://doi.org/10.1038/s41380-021-01287-8
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