P01HL132819

NIH – National Heart, Lung, and Blood Institute

Complement C3 and marginal zone B cells promote IgG-mediated enhancement of RBC alloimmunization in mice

Jash, A., Pridmore, T., Collins, J. B., Hay, A. M., Hudson, K. E., Luckey, C. J., & Zimring, J. C. (2024). Complement C3 and marginal zone B cells promote IgG-mediated enhancement of RBC alloimmunization in mice. Journal of Clinical Investigation, 134(8). https://doi.org/10.1172/jci167665
Authors:
Arijita Jash
Thomas Pridmore
James B. Collins
Ariel Hay
Krystalyn E. Hudson
Chance John Luckey
James C. Zimring
Affiliated Authors:
Krystalyn E. Hudson
Author Keywords:
adaptive immunity
immunology
Grants:
P01HL132819 (NIH – National Heart, Lung, and Blood Institute)
Publication Type:
Article
Unique ID:
10.1172/jci167665
PMID:
Publication Date:
Data Source:
OpenAlex

Record Created:

Antibody-mediated antigen loss switches augmented immunity to antibody-mediated immunosuppression

Jajosky, R. P., Patel, K. R., Allen, J. W. L., Zerra, P. E., Chonat, S., Ayona, D., Maier, C. L., Morais, D., Wu, S.-C., Luckey, C. J., Eisenbarth, S. C., Roback, J. D., Fasano, R. M., Josephson, C. D., Manis, J. P., Chai, L., Hendrickson, J. E., Hudson, K. E., Arthur, C. M., & Stowell, S. R. (2023). Antibody-mediated antigen loss switches augmented immunity to antibody-mediated immunosuppression. Blood, 142(12), 1082–1098. https://doi.org/10.1182/blood.2022018591
Authors:
Ryan P Jajosky
Kashyap R Patel
Jerry William L Allen
Patricia E Zerra
Satheesh Chonat
Diyoly Ayona
Cheryl L Maier
Dominique Morais
Shang-Chuen Wu
C John Luckey
Stephanie C Eisenbarth
John D Roback
Ross M Fasano
Cassandra D Josephson
John P Manis
Li Chai
Jeanne E Hendrickson
Krystalyn E Hudson
Connie M Arthur
Sean R Stowell
Affiliated Authors:
Krystalyn E Hudson
Subjects:
Grants:
R01HL154034 (NIH – National Heart, Lung, and Blood Institute)
K12HL141953 (NIH – National Heart, Lung, and Blood Institute)
R01HL165975 (NIH – National Heart, Lung, and Blood Institute)
T32HL066987 (NIH – National Heart, Lung, and Blood Institute)
R01HL133575 (NIH – National Heart, Lung, and Blood Institute)
P01HL132819 (NIH – National Heart, Lung, and Blood Institute)
Publication Type:
Article
Unique ID:
10.1182/blood.2022018591
PMID:
Journal:
Publication Date:
Data Source:
PubMed

Record Created:

Storage differentially impacts alloimmunization to distinct red cell antigens following transfusion in mice

Maier, C. L., Jajosky, R. P., Patel, S. R., Verkerke, H. P., Fuller, M. D., Allen, J. W., Zerra, P. E., Fasano, R. M., Chonat, S., Josephson, C. D., Gibb, D. R., Eisenbarth, S. C., Luckey, C. J., Hudson, K. E., Hendrickson, J. E., Arthur, C. M., & Stowell, S. R. (2023). Storage differentially impacts alloimmunization to distinct red cell antigens following transfusion in mice. Transfusion, 63(3), 457–462. Portico. https://doi.org/10.1111/trf.17251
Authors:
Cheryl L Maier
Ryan P Jajosky
Seema R Patel
Hans P Verkerke
Megan D Fuller
Jerry William Allen
Patricia E Zerra
Ross M Fasano
Satheesh Chonat
Cassandra D Josephson
David R Gibb
Stephanie C Eisenbarth
C John Luckey
Krystalyn E Hudson
Jeanne E Hendrickson
Connie M Arthur
Sean R Stowell
Affiliated Authors:
Krystalyn E Hudson
Subjects:
Author Keywords:
alloimmunization
blood storage
transfusion
Grants:
R01HL154034 (NIH – National Heart, Lung, and Blood Institute)
R01HL138656 (NIH – National Heart, Lung, and Blood Institute)
K99HL150626 (NIH – National Heart, Lung, and Blood Institute)
P01HL132819 (NIH – National Heart, Lung, and Blood Institute)
R01HL135575 (NIH – National Heart, Lung, and Blood Institute)
T32HL069769 (NIH – National Heart, Lung, and Blood Institute)
T32GM142617 (NIH – National Institute of General Medical Sciences)
Publication Type:
Article
Unique ID:
10.1111/trf.17251
PMID:
Journal:
Publication Date:
Data Source:
PubMed

Record Created:

The role of RBC antigen transgene integration sites on RBC biology in mice

Jash, A., Hay, A. M., Collins, J. B., Heo, J., Luckey, C. J., Hudson, K. E., & Zimring, J. C. (2022). The role of RBC antigen transgene integration sites on RBC biology in mice. Transfusion, 63(1), 239–248. Portico. https://doi.org/10.1111/trf.17197
Authors:
Arijita Jash
Ariel M Hay
J Baodan Collins
Jinho Heo
Chance John Luckey
Krystalyn E Hudson
James C Zimring
Affiliated Authors:
Krystalyn E Hudson
Subjects:
Author Keywords:
alloimmunization
immunology (other than rbc serology)
rbc transfusion
Grants:
P01HL132819 (NIH – National Heart, Lung, and Blood Institute)
Publication Type:
Article
Unique ID:
10.1111/trf.17197
PMID:
Journal:
Publication Date:
Data Source:
PubMed

Record Created:

FcγRIV is required for IgG2c mediated enhancement of RBC alloimmunization

Qiu, A., Miller, A., Zotti, F. D., Santhanakrishnan, M., Hendrickson, J. E., Tredicine, M., Stowell, S. R., Luckey, C. J., Zimring, J. C., & Hudson, K. E. (2022). FcγRIV is required for IgG2c mediated enhancement of RBC alloimmunization. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.972723
Authors:
Annie Qiu
Anabel Miller
Flavia Dei Zotti
Manjula Santhanakrishnan
Jeanne E. Hendrickson
Maria Tredicine
Sean R. Stowell
Chance John Luckey
James C. Zimring
Krystalyn E. Hudson
Affiliated Authors:
Annie Qiu
Anabel Miller
Flavia Dei Zotti
Krystalyn E. Hudson
Author Keywords:
fc receptor
antibody
red blood cell
alloantibody
antibody mediated enhancement
Grants:
P01HL132819 (NIH – National Heart, Lung, and Blood Institute)
R01HL135248 (NIH – National Heart, Lung, and Blood Institute)
Publication Type:
Article
Unique ID:
10.3389/fimmu.2022.972723
PMID:
Publication Date:
Data Source:
OpenAlex

Record Created:

Clodronate inhibits alloimmunization against distinct red blood cell alloantigens in mice

Arthur, C. M., Patel, S. R., Sharma, A., Zerra, P. E., Chonat, S., Jajosky, R. P., Fasano, R. M., Patel, R., Bennett, A., Zhou, X., Luckey, C. J., Hudson, K. E., Eisenbarth, S. C., Josephson, C. D., Roback, J. D., Hendrickson, J. E., & Stowell, S. R. (2022). Clodronate inhibits alloimmunization against distinct red blood cell alloantigens in mice. Transfusion, 62(5), 948–953. Portico. https://doi.org/10.1111/trf.16872
Authors:
Connie M. Arthur
Seema R. Patel
Asish Sharma
Patricia E. Zerra
Satheesh Chonat
Ryan P. Jajosky
Ross M. Fasano
Ravi Patel
Ashley Bennett
Xiaoxi Zhou
C. John Luckey
Krystalyn E. Hudson
Stephanie C. Eisenbarth
Cassandra D. Josephson
John D. Roback
Jeanne E. Hendrickson
Sean R. Stowell
Affiliated Authors:
Krystalyn E. Hudson
Subjects:
Author Keywords:
rbc
alloimmunization
marginal zone macrophages
prevention
Grants:
R01HL135575 (NIH – National Heart, Lung, and Blood Institute)
R01HL154034 (NIH – National Heart, Lung, and Blood Institute)
P01HL132819 (NIH – National Heart, Lung, and Blood Institute)
Publication Type:
Article
Unique ID:
10.1111/trf.16872
PMID:
Journal:
Publication Date:
Data Source:
Scopus

Record Created:

Innate and Adaptive Immunity to Transfused Allogeneic RBCs in Mice Requires MyD88

Soldatenko, A., Hoyt, L. R., Xu, L., Calabro, S., Lewis, S. M., Gallman, A. E., Hudson, K. E., Stowell, S. R., Luckey, C. J., Zimring, J. C., Liu, D., Santhanakrishnan, M., Hendrickson, J. E., & Eisenbarth, S. C. (2022). Innate and Adaptive Immunity to Transfused Allogeneic RBCs in Mice Requires MyD88. The Journal of Immunology, 208(4), 991–997. https://doi.org/10.4049/jimmunol.2100784
Authors:
Arielle Soldatenko
Laura R. Hoyt
Lan Xu
Samuele Calabro
Steven M. Lewis
Antonia E. Gallman
Krystalyn E. Hudson
Sean R. Stowell
Chance J. Luckey
James C. Zimring
Dong Liu
Manjula Santhanakrishnan
Jeanne E. Hendrickson
Stephanie C. Eisenbarth
Affiliated Authors:
Krystalyn E. Hudson
Grants:
P01HL132819 (NIH – National Heart, Lung, and Blood Institute)
Publication Type:
Article
Unique ID:
10.4049/jimmunol.2100784
PMID:
Publication Date:
Data Source:
Scopus

Record Created:

Complement Plays a Critical Role in Inflammation-Induced Immunoprophylaxis Failure in Mice

Escamilla-Rivera, V., Santhanakrishnan, M., Liu, J., Gibb, D. R., Forsmo, J. E., Foxman, E. F., Eisenbarth, S. C., Luckey, C. J., Zimring, J. C., Hudson, K. E., Stowell, S. R., & Hendrickson, J. E. (2021). Complement Plays a Critical Role in Inflammation-Induced Immunoprophylaxis Failure in Mice. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.704072
Authors:
Vicente Escamilla-Rivera
Manjula Santhanakrishnan
Jingchun Liu
David R Gibb
James E Forsmo
Ellen F Foxman
Stephanie C Eisenbarth
C John Luckey
James C Zimring
Krystalyn E Hudson
Sean R Stowell
Jeanne E Hendrickson
Affiliated Authors:
Krystalyn E Hudson
Author Keywords:
red blood cell
complement
antibody
transfusion
alloimmune
Grants:
P30CA016359 (NIH – National Cancer Institute)
UL1TR001863 (NIH – National Center for Advancing Translational Sciences)
R01HL126076 (NIH – National Heart, Lung, and Blood Institute)
R01HL132951 (NIH – National Heart, Lung, and Blood Institute)
K08HL141446 (NIH – National Heart, Lung, and Blood Institute)
P01HL132819 (NIH – National Heart, Lung, and Blood Institute)
U54DK106857 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
Publication Type:
Article
Unique ID:
10.3389/fimmu.2021.704072
PMID:
Publication Date:
Data Source:
PubMed

Record Created:

Antibodies to Low-Copy Number RBC Alloantigen Convert a Tolerogenic Stimulus to an Immunogenic Stimulus in Mice

Jash, A., Usaneerungrueng, C., Howie, H. L., Qiu, A., Luckey, C. J., Zimring, J. C., & Hudson, K. E. (2021). Antibodies to Low-Copy Number RBC Alloantigen Convert a Tolerogenic Stimulus to an Immunogenic Stimulus in Mice. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.629608
Authors:
Arijita Jash
Chomkan Usaneerungrueng
Heather L Howie
Annie Qiu
Chance John Luckey
James C Zimring
Krystalyn E Hudson
Affiliated Authors:
Annie Qiu
Krystalyn E Hudson
Author Keywords:
alloantibody
alloimmunization
antibody-mediated enhancement
red blood cell
tolerance
Grants:
P01HL132819 (NIH – National Heart, Lung, and Blood Institute)
R01HL135248 (NIH – National Heart, Lung, and Blood Institute)
Publication Type:
Article
Unique ID:
10.3389/fimmu.2021.629608
PMID:
Publication Date:
Data Source:
PubMed

Record Created: