Cholinesterase Inhibitors in Neurodegenerative Diseases

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Kenowsky, S., Shao, Y., Heller, S., Golomb, J. B., Vedvyas, A., Dafflisio, G., Zhang, Q., Torossian, H., Sadowski, M. J., Wisniewski, T., Masurkar, A. V., & Reisberg, B. (2024). Nonpharmacologic Management of Behavioral and Psychological Symptoms of Dementia in Community‐Residing Persons with Moderately‐Severe Alzheimer’s Disease: One Year Results from a Randomized Controlled Trial. Alzheimer’s & Dementia, 20(S4). Portico. https://doi.org/10.1002/alz.090018
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Siemers, E. R., Evans, E. E., Fisher, T. L., Boise, M., Foster, A., Leonard, J. E., Mishra, V., Mallow, C. L., Porsteinsson, A. P., Turner, R. S., Bond, W., Huffaker, J., Farlow, M. R., Honig, L. S., Sheldon, E., Townley, R. A., Winner, P., Norton, J., Holub, R., … Zauderer, M. (2024). Results of SIGNAL‐AD, a randomized, phase 1b/2 trial to evaluate safety and efficacy of targeting reactive astrocytes with pepinemab, SEMA4D blocking antibody, in people with mild Alzheimer’s dementia. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.092538
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Huang, A. Y., Zhou, Z., Talukdar, M., Miller, M. B., Chhouk, B., Enyenihi, L., Rosen, I., Stronge, E., Zhao, B., Kim, D., Choi, J., Khoshkhoo, S., Kim, J., Ganz, J., Travaglini, K. J., Gabitto, M. I., Hodge, R. D., Kaplan, E. S., Lein, E. S., … Walsh, C. A. (2024). Enrichment of somatic cancer driver mutations in Alzheimer’s disease microglia and its association with neuroinflammation. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.084786
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Luchsinger, J. A., Feldman, H. H., Messer, K., Edland, S. D., Leger, G. C., Jacobs, D. M., Salmon, D. P., Revta, C., Lupo, J., Durant, J., & Gibson, G. E. (2024). A Seamless Phase 2A‐Phase 2B Multi‐Center Trial to Test the Benefits of Benfotiamine on the Progression of Alzheimer’s Disease‐Benfoteam: Design and Methods. Alzheimer’s & Dementia, 20(S6). Portico. https://doi.org/10.1002/alz.091963
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Telpoukhovskaia, M. A., Murdy, T. J., Marola, O. J., Charland, K., MacLean, M., Luquez, T., Lish, A. M., Neuner, S., Dunn, A., Onos, K. D., Wiley, J., Archer, D., Huentelman, M. J., Arnold, M., Menon, V., Goate, A., Van Eldik, L. J., Territo, P. R., … Howell, G. R. (2024). New directions for Alzheimer’s disease research from the Jackson Laboratory Center for Alzheimer’s and Dementia Research 2022 workshop. Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 10(1). Portico. https://doi.org/10.1002/trc2.12458
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Mitsumoto, H., Cheung, K., Oskarsson, B., Andrews, H. F., Jang, G. E., Andrews, J. A., Shah, J. S., Fernandes, J. A., McElhiney, M., & Santella, R. M. (2023). Randomized double-blind personalized N-of-1 clinical trial to test the safety and potential efficacy of TJ-68 for treating muscle cramps in amyotrophic lateral sclerosis (ALS): study protocol for a TJ-68 trial. Trials, 24(1). https://doi.org/10.1186/s13063-023-07424-8
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Muchtar, E., Sanchorawala, V., Hassan, H., Hegenbart, U., Schonland, S., Lee, H. C., Qazilbash, M. H., Kin, A., Houde, C. A., Buadi, F., Dispenzieri, A., Jacob, E. K., Arai, S., MD, M. C., Chakraborty, R., Lentzsch, S., Magen, H., Shkury, E., Sarubbi, C., … Gertz, M. A. (2023). The Impact of Melphalan Conditioning Schedule on Post-Transplant Outcomes in AL Amyloidosis: A Multicenter Study with 1718 Patients. Blood, 142(Supplement 1), 4784–4784. https://doi.org/10.1182/blood-2023-188115
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Heuer, H. W., Clark, A. L., Brushaber, D., Forsberg, L. K., Miyagawa, T., Staffaroni, A. M., Huey, E. D., Boeve, B. F., Rosen, H. J., Boxer, A. L., & Investigators, A. (2023). Phenoconversion and disease progression observed in mutation carriers of familial Frontotemporal Lobar Degeneration in the ALLFTD Consortium. Alzheimer’s & Dementia, 19(S1). Portico. https://doi.org/10.1002/alz.068191
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Ostrowitzki, S., Bittner, T., Sink, K. M., Mackey, H., Rabe, C., Honig, L. S., Cassetta, E., Woodward, M., Boada, M., van Dyck, C. H., Grimmer, T., Selkoe, D. J., Schneider, A., Blondeau, K., Hu, N., Quartino, A., Clayton, D., Dolton, M., Dang, Y., … Doody, R. S. (2022). Evaluating the Safety and Efficacy of Crenezumab vs Placebo in Adults With Early Alzheimer Disease. JAMA Neurology, 79(11), 1113. https://doi.org/10.1001/jamaneurol.2022.2909
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Martínez-Hernández, J., Parato, J., Sharma, A., Soleilhac, J.-M., Qu, X., Tein, E., Sproul, A., Andrieux, A., Goldberg, Y., Moutin, M.-J., Bartolini, F., & Peris, L. (2022). Crosstalk between acetylation and the tyrosination/detyrosination cycle of α-tubulin in Alzheimer’s disease. Frontiers in Cell and Developmental Biology, 10. https://doi.org/10.3389/fcell.2022.926914
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