Symmetric activation and modulation of the human calcium-sensing receptor

Park, J., Zuo, H., Frangaj, A., Fu, Z., Yen, L. Y., Zhang, Z., Mosyak, L., Slavkovich, V. N., Liu, J., Ray, K. M., Cao, B., Vallese, F., Geng, Y., Chen, S., Grassucci, R., Dandey, V. P., Tan, Y. Z., Eng, E., Lee, Y., … Fan, Q. R. (2021). Symmetric activation and modulation of the human calcium-sensing receptor. Proceedings of the National Academy of Sciences, 118(51). https://doi.org/10.1073/pnas.2115849118
Authors:
Jinseo Park
Hao Zuo
Aurel Frangaj
Ziao Fu
Laura Y Yen
Zhening Zhang
Lidia Mosyak
Vesna N Slavkovich
Jonathan Liu
Kimberly M Ray
Baohua Cao
Francesca Vallese
Yong Geng
Shaoxia Chen
Robert Grassucci
Venkata P Dandey
Yong Zi Tan
Edward Eng
Yeji Lee
Brian Kloss
Zheng Liu
Wayne A Hendrickson
Clinton S Potter
Bridget Carragher
Joseph Graziano
Arthur D Conigrave
Joachim Frank
Oliver B Clarke
Qing R Fan
Affiliated Authors:
Jinseo Park
Hao Zuo
Aurel Frangaj
Ziao Fu
Zhening Zhang
Lidia Mosyak
Vesna N Slavkovich
Jonathan Liu
Kimberly M Ray
Baohua Cao
Francesca Vallese
Yong Geng
Robert Grassucci
Yong Zi Tan
Yeji Lee
Zheng Liu
Wayne A Hendrickson
Clinton S Potter
Bridget Carragher
Joseph Graziano
Joachim Frank
Oliver B Clarke
Qing R Fan
Columbia Affiliation:
Subjects:
Calcium (MeSH)
Gene Expression Regulation (MeSH)
Homeostasis (MeSH)
Receptors, Calcium-Sensing (MeSH)
Author Keywords:
calcium-sensing receptor
cryo-em structure
allosteric modulation
activation mechanism
symmetry
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Publication Type:
Article
Unique ID:
10.1073/pnas.2115849118
PMID:
34916296
DOI:
10.1073/pnas.2115849118
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Publication Date:
Data Source:
PubMed
Source Link:
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Record Created: