Cancer Cell
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Xing, X., Zhong, J., Biermann, J., Duan, H., Zhang, X., Shi, Y., Gao, Y., He, K., Zhai, D., Luo, F., Lai, Y., Xiao, F., Wang, W., Wang, M., Xu, J., Liu, H., Tang, J., Chu, L., Chen, T., … Bai, F. (2025). Pan-cancer human brain metastases atlas at single-cell resolution. Cancer Cell. https://doi.org/10.1016/j.ccell.2025.03.025
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Mosialou, I., Ali, A. M., Labella, R., Bisikirska, B., Cuesta-Dominguez, A., Vgenopoulou, P., Reyes, I., Rao, S. M., Wang, A., Luo, N., Galan-Diez, M., Zhao, J., Chernak, B. J., Bewersdorf, J. P., Fukasawa, K., Su, J., Higa, J., Adams, R. A., Corper, A. L., … Kousteni, S. (2025). A niche driven mechanism determines response and a mutation-independent therapeutic approach for myeloid malignancies. Cancer Cell. https://doi.org/10.1016/j.ccell.2025.03.007
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Vagelos College of Physicians and Surgeons; Department of Physiology and Cellular Biophysics; Department of Medicine; Division of Hematology/Oncology; Center for Radiological Research; Department of Genetics and Development; Department of Systems Biology; Department of Biomedical Informatics; Department of Surgery; Herbert Irving Comprehensive Cancer Center; Department of Orthopedic Surgery
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Henick, B. S., Taylor, A. M., Nakagawa, H., Wong, K.-K., Diehl, J. A., & Rustgi, A. K. (2025). Squamous cell cancers of the aero-upper digestive tract: A unified perspective on biology, genetics, and therapy. Cancer Cell, 43(2), 178–194. https://doi.org/10.1016/j.ccell.2025.01.003
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Gao, J., Gu, D., Yang, K., Zhang, J., Lin, Q., Yuan, W., Zhu, X., Dixit, D., Gimple, R. C., You, H., Zhang, Q., Shi, Z., Fan, X., Wu, Q., Lu, C., Cheng, Z., Li, D., Zhao, L., Xue, B., … Wang, X. (2025). Infiltrating plasma cells maintain glioblastoma stem cells through IgG-Tumor binding. Cancer Cell, 43(1), 122-143.e8. https://doi.org/10.1016/j.ccell.2024.12.006
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Hwang, W. L., Perrault, E. N., Birbrair, A., Mattson, B. J., Gutmann, D. H., Mabbott, D. J., Cukierman, E., Repasky, E. A., Sloan, E. K., Zong, H., Demir, I. E., Saloman, J. L., Borniger, J. C., Hu, J., Dietrich, J., Breunig, J. J., Çifcibaşı, K., Ahmad Kasm, K. A., Valiente, M., … Amit, M. (2024). Integrating priorities at the intersection of cancer and neuroscience. Cancer Cell. https://doi.org/10.1016/j.ccell.2024.09.014
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Yang, Y., Valdés-Rives, S. A., Liu, Q., Gao, T., Burudpakdee, C., Li, Y., Tan, J., Tan, Y., Koch, C. A., Rong, Y., Houser, S. R., Wei, S., Cai, K. Q., Wu, J., Cheng, S., Wechsler-Reya, R., & Yang, Z. (2024). Thyroid hormone suppresses medulloblastoma progression through promoting terminal differentiation of tumor cells. Cancer Cell, 42(8), 1434-1449.e5. https://doi.org/10.1016/j.ccell.2024.07.008
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Liu, J., Cao, S., Imbach, K. J., Gritsenko, M. A., Lih, T.-S. M., Kyle, J. E., Yaron-Barir, T. M., Binder, Z. A., Li, Y., Strunilin, I., Wang, Y.-T., Tsai, C.-F., Ma, W., Chen, L., Clark, N. M., Shinkle, A., Naser Al Deen, N., Caravan, W., Houston, A., … Ding, L. (2024). Multi-scale signaling and tumor evolution in high-grade gliomas. Cancer Cell, 42(7), 1217-1238.e19. https://doi.org/10.1016/j.ccell.2024.06.004
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Liu, Y., Su, Z., Tavana, O., & Gu, W. (2024). Understanding the complexity of p53 in a new era of tumor suppression. Cancer Cell, 42(6), 946–967. https://doi.org/10.1016/j.ccell.2024.04.009
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Koschmann, C., Al-Holou, W. N., Alonso, M. M., Anastas, J., Bandopadhayay, P., Barron, T., Becher, O., Cartaxo, R., Castro, M. G., Chung, C., Clausen, M., Dang, D., Doherty, R., Duchatel, R., Dun, M., Filbin, M., Franson, A., Galban, S., Garcia Moure, M., … Venneti, S. (2024). A road map for the treatment of pediatric diffuse midline glioma. Cancer Cell, 42(1), 1–5. https://doi.org/10.1016/j.ccell.2023.11.002
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Hawley, J. E., Obradovic, A. Z., Dallos, M. C., Lim, E. A., Runcie, K., Ager, C. R., McKiernan, J., Anderson, C. B., Decastro, G. J., Weintraub, J., Virk, R., Lowy, I., Hu, J., Chaimowitz, M. G., Guo, X. V., Zhang, Y., Haffner, M. C., Worley, J., Stein, M. N., … Drake, C. G. (2023). Anti-PD-1 immunotherapy with androgen deprivation therapy induces robust immune infiltration in metastatic castration-sensitive prostate cancer. Cancer Cell, 41(11), 1972-1988.e5. https://doi.org/10.1016/j.ccell.2023.10.006
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Columbia Affiliation
Vagelos College of Physicians and Surgeons; Department of Medicine; Department of Urology; Department of Pathology and Cell Biology; Mailman School of Public Health; Department of Biostatistics; Herbert Irving Comprehensive Cancer Center; Department of Neurology; Department of Systems Biology; Division of Hematology/Oncology; Department of Biochemistry and Molecular Biophysics; Department of Biomedical Informatics; Center for Translational Immunology; JP Sulzberger Columbia Genome Center
Rajbhandari, N., Hamilton, M., Quintero, C. M., Ferguson, L. P., Fox, R., Schürch, C. M., Wang, J., Nakamura, M., Lytle, N. K., McDermott, M., Diaz, E., Pettit, H., Kritzik, M., Han, H., Cridebring, D., Wen, K. W., Tsai, S., Goggins, M. G., Lowy, A. M., … Reya, T. (2023). Single-cell mapping identifies MSI+ cells as a common origin for diverse subtypes of pancreatic cancer. Cancer Cell, 41(11), 1989-2005.e9. https://doi.org/10.1016/j.ccell.2023.09.008
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Ho, P., Melms, J. C., Rogava, M., Frangieh, C. J., Poźniak, J., Shah, S. B., Walsh, Z., Kyrysyuk, O., Amin, A. D., Caprio, L., Fullerton, B. T., Soni, R. K., Ager, C. R., Biermann, J., Wang, Y., Khosravi-Maharlooei, M., Zanetti, G., Mu, M., Fatima, H., … Izar, B. (2023). The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity. Cancer Cell, 41(7), 1207-1221.e12. https://doi.org/10.1016/j.ccell.2023.05.014
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Columbia Affiliation
Vagelos College of Physicians and Surgeons; Department of Medicine; Department of Pediatrics; Division of Hematology/Oncology; Herbert Irving Comprehensive Cancer Center; Department of Microbiology and Immunology; Department of Surgery; Division of Abdominal Organ Transplantation; Department of Systems Biology; Center for Translational Immunology; Division of Rheumatology
Obradovic, A., Ager, C., Turunen, M., Nirschl, T., Khosravi-Maharlooei, M., Iuga, A., Jackson, C. M., Yegnasubramanian, S., Tomassoni, L., Fernandez, E. C., McCann, P., Rogava, M., DeMarzo, A. M., Kochel, C. M., Allaf, M., Bivalacqua, T., Lim, M., Realubit, R., Karan, C., … Califano, A. (2023). Systematic elucidation and pharmacological targeting of tumor-infiltrating regulatory T cell master regulators. Cancer Cell, 41(5), 933-949.e11. https://doi.org/10.1016/j.ccell.2023.04.003
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Columbia Affiliation
Vagelos College of Physicians and Surgeons; Department of Medicine; Department of Systems Biology; Department of Biochemistry and Molecular Biophysics; Department of Biomedical Informatics; Division of Hematology/Oncology; Herbert Irving Comprehensive Cancer Center; JP Sulzberger Columbia Genome Center
Pan, Y., Han, H., Hu, H., Wang, H., Song, Y., Hao, Y., Tong, X., Patel, A. S., Misirlioglu, S., Tang, S., Huang, H.-Y., Geng, K., Chen, T., Karatza, A., Sherman, F., Labbe, K. E., Yang, F., Chafitz, A., Peng, C., … Wong, K.-K. (2023). KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition. Cancer Cell, 41(1), 88-105.e8. https://doi.org/10.1016/j.ccell.2022.11.015
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Salomé, B., Sfakianos, J. P., Ranti, D., Daza, J., Bieber, C., Charap, A., Hammer, C., Banchereau, R., Farkas, A. M., Ruan, D. F., Izadmehr, S., Geanon, D., Kelly, G., de Real, R. M., Lee, B., Beaumont, K. G., Shroff, S., Wang, Y. A., Wang, Y., … Horowitz, A. (2022). NKG2A and HLA-E define an alternative immune checkpoint axis in bladder cancer. Cancer Cell, 40(9), 1027-1043.e9. https://doi.org/10.1016/j.ccell.2022.08.005
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Kurz, E., Hirsch, C. A., Dalton, T., Shadaloey, S. A., Khodadadi-Jamayran, A., Miller, G., Pareek, S., Rajaei, H., Mohindroo, C., Baydogan, S., Ngo-Huang, A., Parker, N., Katz, M. H. G., Petzel, M., Vucic, E., McAllister, F., Schadler, K., Winograd, R., & Bar-Sagi, D. (2022). Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer. Cancer Cell, 40(7), 720-737.e5. https://doi.org/10.1016/j.ccell.2022.05.006
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Jaiswal, A., Verma, A., Dannenfelser, R., Melssen, M., Tirosh, I., Izar, B., Kim, T.-G., Nirschl, C. J., Devi, K. S. P., Olson, W. C., Slingluff, C. L., Engelhard, V. H., Garraway, L., Regev, A., Minkis, K., Yoon, C. H., Troyanskaya, O., Elemento, O., Suárez-Fariñas, M., & Anandasabapathy, N. (2022). An activation to memory differentiation trajectory of tumor-infiltrating lymphocytes informs metastatic melanoma outcomes. Cancer Cell, 40(5), 524-544.e5. https://doi.org/10.1016/j.ccell.2022.04.005
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