The ATM Kinase Inhibitor AZD0156 Is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4-Kinase (PI4Kβ) and Is an Attractive Candidate for Medicinal Chemistry Optimization Against Malaria

Woodland, J. G., Coertzen, D., Wicht, K. J., Hidalgo, V. F., Pasaje, C. F. A., Godoy, L. C., Qahash, T., Mmonwa, M. M., Dziwornu, G. A., Wambua, L., Harries, S., Korkor, C. M., Njoroge, M., Krugmann, L., Taylor, D., Leshabane, M., Langeveld, H., Rabie, T., Reader, J., … Chibale, K. (2025). The ATM Kinase Inhibitor AZD0156 Is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4‐Kinase (PI4Kβ) and Is an Attractive Candidate for Medicinal Chemistry Optimization Against Malaria. Angewandte Chemie International Edition. Portico. https://doi.org/10.1002/anie.202425206
Authors:
John G Woodland
Dina Coertzen
Kathryn J Wicht
Virginia Franco Hidalgo
Charisse Flerida A Pasaje
Luiz C Godoy
Tarrick Qahash
Mmakwena M Mmonwa
Godwin A Dziwornu
Lynn Wambua
Sarah Harries
Constance M Korkor
Mathew Njoroge
Liezl Krugmann
Dale Taylor
Meta Leshabane
Henrico Langeveld
Tayla Rabie
Janette Reader
Mariëtte van der Watt
Nelius Venter
Erica Erlank
Ayesha S Aswat
Lizette L Koekemoer
Tomas Yeo
Jin H Jeon
David A Fidock
Francisco Javier Gamo
Sergio Wittlin
Jacquin C Niles
Manuel Llinas
Lauren B Coulson
Lyn-Marié Birkholtz
Kelly Chibale
Affiliated Authors:
Tomas Yeo
Jin H Jeon
David A Fidock
Columbia Affiliation:
Subjects:
Efficacy and Safety of Antiretroviral Therapy for HIV (OpenAlex Topic)
Malaria (OpenAlex Topic)
Epidemiology and Treatment of Chagas Disease (OpenAlex Topic)
Author Keywords:
antiplasmodial
biological activity
malaria
medicinal chemistry
phosphatidylinositol 4‐kinase type iii beta (pi4kβ)
repositioning
elink
Publication Type:
Article
Unique ID:
10.1002/anie.202425206
PMID:
40317875
DOI:
10.1002/anie.202425206
Journal:
Angewandte Chemie (International Edition)
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View OpenAlex Record

Record Created: