Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention

Summers, R. L., Pasaje, C. F. A., Pisco, J. P., Striepen, J., Luth, M. R., Kumpornsin, K., Carpenter, E. F., Munro, J. T., Lin, D., Plater, A., Punekar, A. S., Shepherd, A. M., Shepherd, S. M., Vanaerschot, M., Murithi, J. M., Rubiano, K., Akidil, A., Ottilie, S., Mittal, N., … Lukens, A. K. (2022). Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention. Cell Chemical Biology, 29(2), 191-201.e8. https://doi.org/10.1016/j.chembiol.2021.07.010
Authors:
Robert L. Summers
Charisse Flerida A. Pasaje
Joao P. Pisco
Josefine Striepen
Madeline R. Luth
Krittikorn Kumpornsin
Emma F. Carpenter
Justin T. Munro
De Lin
Andrew Plater
Avinash S. Punekar
Andrew M. Shepherd
Sharon M. Shepherd
Manu Vanaerschot
James M. Murithi
Kelly Rubiano
Aslı Akidil
Sabine Ottilie
Nimisha Mittal
A. Hazel Dilmore
Madalyn Won
Rebecca E.K. Mandt
Kerry McGowen
Edward Owen
Chris Walpole
Manuel Llinás
Marcus C.S. Lee
Elizabeth A. Winzeler
David A. Fidock
Ian H. Gilbert
Dyann F. Wirth
Jacquin C. Niles
Beatriz Baragaña
Amanda K. Lukens
Affiliated Authors:
Josefine Striepen
Manu Vanaerschot
James M. Murithi
Kelly Rubiano
David A. Fidock
Columbia Affiliation:
Author Keywords:
acetyl-coa synthetase
antimalarial
drug development
drug target identification
histone acetylation
malaria
mechanism of action
plasmodium falciparum
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Publication Type:
Article
Unique ID:
10.1016/j.chembiol.2021.07.010
PMID:
34348113
DOI:
10.1016/j.chembiol.2021.07.010
Journal:
Cell Chemical Biology
Publication Date:
Data Source:
Scopus
Source Link:
View Scopus Record
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Record Created: