Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance

Luth, M. R., Godinez-Macias, K. P., Chen, D., Okombo, J., Thathy, V., Cheng, X., Daggupati, S., Davies, H., Dhingra, S. K., Economy, J. M., Edgar, R. C. S., Gomez-Lorenzo, M. G., Istvan, E. S., Jado, J. C., LaMonte, G. M., Melillo, B., Mok, S., Narwal, S. K., Ndiaye, T., … Winzeler, E. A. (2024). Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance. Science, 386(6725). https://doi.org/10.1126/science.adk9893
Authors:
Madeline R. Luth
Karla P. Godinez‐Macias
Daisy Chen
John Okombo
Vandana Thathy
Xiu Cheng
Sindhu Daggupati
Heledd Davies
Satish K. Dhingra
James Economy
Rebecca Edgar
Marı́a G. Gómez-Lorenzo
Eva S. Istvan
Juan Carlos Jado
Gregory LaMonte
Bruno Melillo
Sachel Mok
Sunil Kumar Narwal
Tolla Ndiaye
Sabine Ottilie
Sara Palomo Dı́az
Heekuk Park
Stella Peña
Frances Rocamora
Tomoyo Sakata‐Kato
Jennifer L. Small-Saunders
Robert L. Summers
Patrick K. Tumwebaze
Manu Vanaerschot
Guoqin Xia
Tomas Yeo
A. You
Francisco‐Javier Gamo
Daniel E. Goldberg
Lee M
Case W. McNamara
Daouda Ndiaye
Philip J. Rosenthal
Stuart L. Schreiber
Gloria Serra
Jair L. Siqueira-Neto
Tina S. Skinner‐Adams
Anne‐Catrin Uhlemann
Nobutaka Kato
Amanda K. Lukens
Dyann F. Wirth
David A. Fidock
Elizabeth A. Winzeler
Affiliated Authors:
John Okombo
Vandana Thathy
Satish K. Dhingra
Sachel Mok
Sunil Kumar Narwal
Tolla Ndiaye
Heekuk Park
Jennifer L. Small-Saunders
Manu Vanaerschot
Tomas Yeo
Anne‐Catrin Uhlemann
David A. Fidock
Columbia Affiliation:
Subjects:
Antimalarials (MeSH)
Drug Resistance (MeSH)
Drug Resistance, Multiple (MeSH)
Plasmodium falciparum (MeSH)
Protozoan Proteins (MeSH)
Directed Molecular Evolution (MeSH)
Malaria (OpenAlex Topic)
Invertebrate Immunity and Host Defense Mechanisms (OpenAlex Topic)
Aquaculture disease management and microbiota (OpenAlex Topic)
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Publication Type:
Article
Unique ID:
10.1126/science.adk9893
PMID:
39607932
DOI:
10.1126/science.adk9893
Journal:
Science
Publication Date:
Data Source:
OpenAlex
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