Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages

Okombo, J., Mok, S., Qahash, T., Yeo, T., Bath, J., Orchard, L. M., Owens, E., Koo, I., Albert, I., Llinás, M., & Fidock, D. A. (2022). Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages. PLOS Pathogens, 18(10), e1010926. https://doi.org/10.1371/journal.ppat.1010926

Authors:

John Okombo

Sachel Mok

Tarrick Qahash

Tomas Yeo

Jade Bath

Lindsey Orchard

Edward Owen

Imhoi Koo

István Albert

Manuel Llinás

David A. Fidock