Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19

Liu, H., Iketani, S., Zask, A., Khanizeman, N., Bednarova, E., Forouhar, F., Fowler, B., Hong, S. J., Mohri, H., Nair, M. S., Huang, Y., Tay, N. E. S., Lee, S., Karan, C., Resnick, S. J., Quinn, C., Li, W., Shion, H., Xia, X., … Stockwell, B. R. (2022). Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-29413-2
Authors:
Hengrui Liu
Sho Iketani
Arie Zask
Nisha Khanizeman
Eva Bednarova
Farhad Forouhar
Brandon Fowler
Seo Jung Hong
Hiroshi Mohri
Manoj S. Nair
Yaoxing Huang
Nicholas E. S. Tay
Sumin Lee
Charles Karan
Samuel J. Resnick
Colette Quinn
Wenjing Li
Henry Shion
Xin Xia
Jacob D. Daniels
Michelle Bartolo-Cruz
Marcelo Farina
Presha Rajbhandari
Christopher Jurtschenko
Matthew A. Lauber
Thomas McDonald
Michael E. Stokes
Brett L. Hurst
Tomislav Rovis
Alejandro Chavez
David D. Ho
Brent R. Stockwell
Affiliated Authors:
Sho Iketani
Arie Zask
Farhad Forouhar
Seo Jung Hong
Hiroshi Mohri
Manoj S. Nair
Yaoxing Huang
Charles Karan
Samuel J. Resnick
Xin Xia
Jacob D. Daniels
Michelle Bartolo-Cruz
Marcelo Farina
Presha Rajbhandari
Michael E. Stokes
Alejandro Chavez
David D. Ho
Brent R. Stockwell
Columbia Affiliation:
Subjects:
Antiviral Agents (MeSH)
Coronavirus 3C Proteases (MeSH)
Protease Inhibitors (MeSH)
COVID-19 Drug Treatment (MeSH)
Coronavirus Disease 2019 Research (OpenAlex Topic)
Computational Methods in Drug Discovery (OpenAlex Topic)
Coronavirus Disease 2019 (OpenAlex Topic)
COVID-19 (MeSH)
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Publication Type:
Article
Unique ID:
10.1038/s41467-022-29413-2
PMID:
35393402
DOI:
10.1038/s41467-022-29413-2
Journal:
Nature Communications
Publication Date:
Data Source:
Scopus
Source Link:
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