Discovery and Evaluation of C6-Substituted Pyrazolopyrimidine-Based Bisphosphonate Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase and Evaluation of Their Antitumor Efficacy in Multiple Myeloma, Pancreatic Ductal Adenocarcinoma, and Colorectal Cancer

Boutin, R., Lee, H.-F., Guan, T. L., Nguyen, T. T., Huang, X. F., Waller, D. D., Lu, J., Christine Chio, I. I., Michel, R. P., Sebag, M., & Tsantrizos, Y. S. (2023). Discovery and Evaluation of C6-Substituted Pyrazolopyrimidine-Based Bisphosphonate Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase and Evaluation of Their Antitumor Efficacy in Multiple Myeloma, Pancreatic Ductal Adenocarcinoma, and Colorectal Cancer. Journal of Medicinal Chemistry, 66(23), 15776–15800. https://doi.org/10.1021/acs.jmedchem.3c01271
Authors:
Rebecca Boutin
Hiu-Fung Lee
Tian Lai Guan
Tan Trieu Nguyen
Xian Fang Huang
Daniel D Waller
Jordan Lu
Iok In Christine Chio
René P Michel
Michael Sebag
Youla S Tsantrizos
Affiliated Authors:
Jordan Lu
Iok In Christine Chio
Columbia Affiliation:
Subjects:
Multiple Myeloma (MeSH)
Pancreatic Neoplasms (MeSH)
Carcinoma, Pancreatic Ductal (MeSH)
Colorectal Neoplasms (MeSH)
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Publication Type:
Article
Unique ID:
10.1021/acs.jmedchem.3c01271
PMID:
37982711
DOI:
10.1021/acs.jmedchem.3c01271
Journal:
Journal of Medicinal Chemistry
Publication Date:
Data Source:
PubMed
Source Link:
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