Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons

Al-Dalahmah, O., Lam, M., McInvale, J. J., Qu, W., Nguyen, T., Mun, J.-Y., Kwon, S., Ifediora, N., Mahajan, A., Humala, N., Winters, T., Angeles, E., Jakubiak, K. A., Kühn, R., Kim, Y. A., De Rosa, M. C., Doege, C. A., Paryani, F., Flowers, X., … Hargus, G. (2024). Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons. Cell Stem Cell, 31(5), 676-693.e10. https://doi.org/10.1016/j.stem.2024.03.013
Authors:
Osama Al-Dalahmah
Matti Lam
Julie J McInvale
Wenhui Qu
Trang Nguyen
Jeong-Yeon Mun
Sam Kwon
Nkechime Ifediora
Aayushi Mahajan
Nelson Humala
Tristan Winters
Ellen Angeles
Kelly A Jakubiak
Rebekka Kühn
Yoon A Kim
Maria Caterina De Rosa
Claudia A Doege
Fahad Paryani
Xena Flowers
Athanassios Dovas
Angeliki Mela
Hong Lu
Michael A DeTure
Jean Paul Vonsattel
Zbigniew K Wszolek
Dennis W Dickson
Tanja Kuhlmann
Holm Zaehres
Hans R Schöler
Andrew A Sproul
Markus D Siegelin
Philip L De Jager
James E Goldman
Vilas Menon
Peter Canoll
Gunnar Hargus
Affiliated Authors:
Osama Al-Dalahmah
Matti Lam
Julie J McInvale
Wenhui Qu
Trang Nguyen
Jeong-Yeon Mun
Sam Kwon
Nkechime Ifediora
Aayushi Mahajan
Nelson Humala
Tristan Winters
Ellen Angeles
Kelly A Jakubiak
Rebekka Kühn
Yoon A Kim
Maria Caterina De Rosa
Claudia A Doege
Fahad Paryani
Xena Flowers
Athanassios Dovas
Angeliki Mela
Hong Lu
Jean Paul Vonsattel
Andrew A Sproul
Markus D Siegelin
Philip L De Jager
James E Goldman
Vilas Menon
Peter Canoll
Gunnar Hargus
Columbia Affiliation:
Subjects:
Role of Osteopontin in Biomineralization and Inflammation (OpenAlex Topic)
Mechanisms of Alzheimer's Disease (OpenAlex Topic)
Bioactive Peptides in Food and Health (OpenAlex Topic)
Osteopontin (MeSH)
Frontotemporal Dementia (MeSH)
Neurons (MeSH)
tau Proteins (MeSH)
Author Keywords:
disease modeling
frontotemporal dementia
ftd
induced pluripotent stem cells
mapt n279k
microglia
neuroinflammation
opn
osteopontin
single nucleus rna sequencing
snrna-seq
spp1
tau
transplantation
elink
Publication Type:
Article
Unique ID:
10.1016/j.stem.2024.03.013
PMID:
38626772
DOI:
10.1016/j.stem.2024.03.013
Journal:
Cell Stem Cell
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View OpenAlex Record
View Scopus Record
View Web of Science Record

Record Created: