R01NS118513

NIH – National Institute of Neurological Disorders and Stroke

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Multiplexed single-cell lineage tracing of mitotic kinesin inhibitor resistance in glioblastoma

Cheng, Y. L., Banu, M. A., Zhao, W., Rosenfeld, S. S., Canoll, P., & Sims, P. A. (2024). Multiplexed single-cell lineage tracing of mitotic kinesin inhibitor resistance in glioblastoma. Cell Reports, 43(5), 114139. https://doi.org/10.1016/j.celrep.2024.114139
Authors:
Yim Ling Cheng
Matei A Banu
Wenting Zhao
Steven S Rosenfeld
Peter Canoll
Peter A Sims
Affiliated Authors:
Yim Ling Cheng
Matei A Banu
Wenting Zhao
Peter Canoll
Peter A Sims
Columbia Affiliation:
Subjects:
Gliomas (OpenAlex Topic)
Regulation and Function of Microtubules in Cell Division (OpenAlex Topic)
Mathematical Modeling of Cancer Growth and Treatment (OpenAlex Topic)
Glioblastoma (MeSH)
Kinesins (MeSH)
Drug Resistance, Neoplasm (MeSH)
Single-Cell Analysis (MeSH)
Cell Lineage (MeSH)
Author Keywords:
cp: cancer
cp: cell biology
drug resistance
glioblastoma
mitotic kinesins
multiplexed lineage tracing
single-cell genomics
Grants:
U01CA168426 (NIH – National Cancer Institute)
U01CA272610 (NIH – National Cancer Institute)
R01NS118513 (NIH – National Institute of Neurological Disorders and Stroke)
R01NS103473 (NIH – National Institute of Neurological Disorders and Stroke)
Publication Type:
Article
Unique ID:
10.1016/j.celrep.2024.114139
PMID:
38652658
DOI:
10.1016/j.celrep.2024.114139
Journal:
Cell Reports
Publication Date:
Data Source:
PubMed
Source Link:
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Record Created:

Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma

Kenchappa, R. S., Dovas, A., Argenziano, M. G., Meyer, C. T., Stopfer, L. E., Banu, M. A., Pereira, B., Griffith, J., Mohammad, A., Talele, S., Haddock, A., Zarco, N., Elmquist, W., White, F., Quaranta, V., Sims, P., Canoll, P., & Rosenfeld, S. S. (2022). Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma. Cell Reports, 39(12), 110991. https://doi.org/10.1016/j.celrep.2022.110991
Authors:
Rajappa S Kenchappa
Athanassios Dovas
Michael G Argenziano
Christian T Meyer
Lauren E Stopfer
Matei A Banu
Brianna Pereira
Jessica Griffith
Afroz Mohammad
Surabhi Talele
Ashley Haddock
Natanael Zarco
William Elmquist
Forest White
Vito Quaranta
Peter Sims
Peter Canoll
Steven S Rosenfeld
Affiliated Authors:
Athanassios Dovas
Michael G Argenziano
Matei A Banu
Brianna Pereira
Peter Sims
Peter Canoll
Columbia Affiliation:
Subjects:
Antimitotic Agents (MeSH)
Glioblastoma (MeSH)
Author Keywords:
cp: cancer
egfr
glioblastoma
inhibitor
kinesin
src
stat3
Grants:
U01CA238720 (NIH – National Cancer Institute)
R38CA231577 (NIH – National Cancer Institute)
U54CA210180 (NIH – National Cancer Institute)
T32DK101003 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
T32ES007020 (NIH – National Institute of Environmental Health Sciences)
R01NS073610 (NIH – National Institute of Neurological Disorders and Stroke)
R01NS118513 (NIH – National Institute of Neurological Disorders and Stroke)
Publication Type:
Article
Unique ID:
10.1016/j.celrep.2022.110991
PMID:
35732128
DOI:
10.1016/j.celrep.2022.110991
Journal:
Cell Reports
Publication Date:
Data Source:
PubMed
Source Link:
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Record Created:

Protein kinase Cι and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities

Kenchappa, R. S., Liu, Y., Argenziano, M. G., Banu, M. A., Mladek, A. C., West, R., Luu, A., Quiñones-Hinojosa, A., Hambardzumyan, D., Justilien, V., Leitges, M., Sarkaria, J. N., Sims, P. A., Canoll, P., Murray, N. R., Fields, A. P., & Rosenfeld, S. S. (2021). Protein kinase Cι and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities. Cell Reports, 37(8), 110054. https://doi.org/10.1016/j.celrep.2021.110054
Authors:
Rajappa S Kenchappa
Yi Liu
Michael G Argenziano
Matei A Banu
Ann C Mladek
Rita West
Amanda Luu
Alfredo Quiñones-Hinojosa
Dolores Hambardzumyan
Verline Justilien
Michael Leitges
Jann N Sarkaria
Peter A Sims
Peter Canoll
Nicole R Murray
Alan P Fields
Steven S Rosenfeld
Affiliated Authors:
Michael G Argenziano
Matei A Banu
Peter A Sims
Peter Canoll
Columbia Affiliation:
Subjects:
Gliomas (OpenAlex Topic)
Mammalian MAP Kinase Signaling Pathways (OpenAlex Topic)
Molecular Mechanisms of Ras Signaling Pathways (OpenAlex Topic)
Glioblastoma (MeSH)
Isoenzymes (MeSH)
Protein Kinase C (MeSH)
Author Keywords:
glioblastoma
kinase inhibitor
protein kinase c iota
src
Grants:
R01CA206367 (NIH – National Cancer Institute)
R01CA216855 (NIH – National Cancer Institute)
R01CA081436 (NIH – National Cancer Institute)
R01CA195503 (NIH – National Cancer Institute)
R01CA200399 (NIH – National Cancer Institute)
U01CA227954 (NIH – National Cancer Institute)
U54CA210180 (NIH – National Cancer Institute)
R01NS100864 (NIH – National Institute of Neurological Disorders and Stroke)
R01NS118513 (NIH – National Institute of Neurological Disorders and Stroke)
R21NS106554 (NIH – National Institute of Neurological Disorders and Stroke)
R01NS073610 (NIH – National Institute of Neurological Disorders and Stroke)
R61NS119714 (NIH – National Institute of Neurological Disorders and Stroke)
Publication Type:
Article
Unique ID:
10.1016/j.celrep.2021.110054
PMID:
34818553
DOI:
10.1016/j.celrep.2021.110054
Journal:
Cell Reports
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View OpenAlex Record
View Scopus Record
View Web of Science Record

Record Created:

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