R01MH107615

NIH – National Institute of Mental Health

Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions

Loan Nguyen, T. M., Guilloux, J.-P., Defaix, C., Mendez-David, I., Etting, I., Alvarez, J.-C., McGowan, J. C., Highland, J. N., Zanos, P., Lovett, J., Moaddel, R., Corruble, E., David, D. J., Gould, T. D., Denny, C. A., & Gardier, A. M. (2024). Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions. Neuropharmacology, 258, 110065. https://doi.org/10.1016/j.neuropharm.2024.110065
Authors:
Thi Mai Loan Nguyen
Jean-Philippe Guilloux
Celine Defaix
Indira Mendez-David
Denis J. David
Alain M. Gardier
Emmanuelle Corruble
Isabelle Etting
Josephine C. McGowan
Christine A. Denny
Jaclyn N. Highland
Panos Zanos
Todd D. Gould
Jacqueline Lovett
Ruin Moaddel
Affiliated Authors:
Josephine C. McGowan
Christine A. Denny
Author Keywords:
(r,s)-ketamine
cytochrome p450 inhibitor
fluconazole
gaba
glutamate
hnk
hydroxynorketamine
medial prefrontal cortex
microdialysis
rapid-acting antidepressant
Grants:
R01MH107615 (NIH – National Institute of Mental Health)
I01BX004062 (NIH – Veterans Affairs)
I01BX006018 (NIH – Veterans Affairs)
Publication Type:
Article
Unique ID:
10.1016/j.neuropharm.2024.110065
PMID:
Publication Date:
Data Source:
Web of Science

Record Created:

Blood-based biomarkers of antidepressant response to ketamine and esketamine: A systematic review and meta-analysis

Medeiros, G. C., Gould, T. D., Prueitt, W. L., Nanavati, J., Grunebaum, M. F., Farber, N. B., Singh, B., Selvaraj, S., Machado-Vieira, R., Achtyes, E. D., Parikh, S. V., Frye, M. A., Zarate, C. A., & Goes, F. S. (2022). Blood-based biomarkers of antidepressant response to ketamine and esketamine: A systematic review and meta-analysis. Molecular Psychiatry, 27(9), 3658–3669. https://doi.org/10.1038/s41380-022-01652-1
Authors:
Gustavo C Medeiros
Todd D Gould
William L Prueitt
Julie Nanavati
Michael F Grunebaum
Nuri B Farber
Balwinder Singh
Sudhakar Selvaraj
Rodrigo Machado-Vieira
Eric D Achtyes
Sagar V Parikh
Mark A Frye
Carlos A Zarate
Fernando S Goes
Affiliated Authors:
Michael F Grunebaum
Grants:
R21AI145211 (NIH – National Institute of Allergy and Infectious Diseases)
R01MH107615 (NIH – National Institute of Mental Health)
R21MH119441 (NIH – National Institute of Mental Health)
I01BX003631 (NIH – Veterans Affairs)
I01BX004062 (NIH – Veterans Affairs)
Publication Type:
Article
Unique ID:
10.1038/s41380-022-01652-1
PMID:
Publication Date:
Data Source:
PubMed

Record Created: