Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions

Loan Nguyen, T. M., Guilloux, J.-P., Defaix, C., Mendez-David, I., Etting, I., Alvarez, J.-C., McGowan, J. C., Highland, J. N., Zanos, P., Lovett, J., Moaddel, R., Corruble, E., David, D. J., Gould, T. D., Denny, C. A., & Gardier, A. M. (2024). Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions. Neuropharmacology, 258, 110065. https://doi.org/10.1016/j.neuropharm.2024.110065
Authors:
Thi Mai Loan Nguyen
Jean-Philippe Guilloux
Celine Defaix
Indira Mendez-David
Denis J. David
Alain M. Gardier
Emmanuelle Corruble
Isabelle Etting
Josephine C. McGowan
Christine A. Denny
Jaclyn N. Highland
Panos Zanos
Todd D. Gould
Jacqueline Lovett
Ruin Moaddel
Affiliated Authors:
Josephine C. McGowan
Christine A. Denny
Author Keywords:
(r,s)-ketamine
cytochrome p450 inhibitor
fluconazole
gaba
glutamate
hnk
hydroxynorketamine
medial prefrontal cortex
microdialysis
rapid-acting antidepressant
Publication Type:
Article
Unique ID:
10.1016/j.neuropharm.2024.110065
PMID:
Publication Date:
Data Source:
Web of Science

Record Created: