R01HL090682

NIH – National Heart, Lung, and Blood Institute

Rare coding variants in RCN3 are associated with blood pressure

He, K. Y., Kelly, T. N., Wang, H., Liang, J., Zhu, L., Cade, B. E., Assimes, T. L., Becker, L. C., Beitelshees, A. L., Bielak, L. F., Bress, A. P., Brody, J. A., Chang, Y.-P. C., Chang, Y.-C., de Vries, P. S., Duggirala, R., Fox, E. R., Franceschini, N., Furniss, A. L., … Zhu, X. (2022). Rare coding variants in RCN3 are associated with blood pressure. BMC Genomics, 23(1). https://doi.org/10.1186/s12864-022-08356-4

Authors:

Karen Y. He

Tanika N. Kelly

Heming Wang

Jingjing Liang

Luke Zhu

Brian E. Cade

Themistocles L. Assimes

Lewis C. Becker

Amber L. Beitelshees

Lawrence F. Bielak

Adam P. Bress

Jennifer A. Brody

Yen-Pei Christy Chang

Yi-Cheng Chang

Paul S. de Vries

Ravindranath Duggirala

Ervin R. Fox

Nora Franceschini

Anna L. Furniss

Yan Gao

Xiuqing Guo

Jeffrey Haessler

Yi-Jen Hung

Shih-Jen Hwang

Marguerite Ryan Irvin

Rita R. Kalyani

Ching-Ti Liu

Chunyu Liu

Lisa Warsinger Martin

May E. Montasser

Paul M. Muntner

Stanford Mwasongwe

Take Naseri

Walter Palmas

Muagututi’a Sefuiva Reupena

Kenneth M. Rice

Wayne H.-H. Sheu

Daichi Shimbo

Jennifer A. Smith

Beverly M. Snively

Lisa R. Yanek

Wei Zhao

John Blangero

Eric Boerwinkle

Yii-Der Ida Chen

Adolfo Correa

L. Adrienne Cupples

Joanne E. Curran

Myriam Fornage

Jiang He

Lifang Hou

Robert C. Kaplan

Sharon L. R. Kardia

Eimear E. Kenny

Charles Kooperberg

Donald Lloyd-Jones

Ruth J. F. Loos

Rasika A. Mathias

Stephen T. McGarvey

Braxton D. Mitchell

Kari E. North

Patricia A. Peyser

Bruce M. Psaty

Laura M. Raffield

D.C. Rao

Susan Redline

Alex P. Reiner

Stephen S. Rich

Jerome I. Rotter

Kent D. Taylor

Russell Tracy

Ramachandran S. Vasan

Alanna C. Morrison

Daniel Levy

Aravinda Chakravarti

Donna K. Arnett

Xiaofeng Zhu

Affiliated Authors:

Walter Palmas

Daichi Shimbo

Columbia Affiliation:

Subjects:

Genome-Wide Association Study (MeSH)

Precision Medicine (MeSH)

Genomic Studies and Association Analyses (OpenAlex Topic)

Standards and Guidelines for Genetic Variant Interpretation (OpenAlex Topic)

Genetic Research on BRCA Mutations and Cancer Risk (OpenAlex Topic)

Author Keywords:

blood pressure

rare variant analysis

whole genome sequencing

Grants:

UL1TR001079 (NIH – National Center for Advancing Translational Sciences)

UL1TR001420 (NIH – National Center for Advancing Translational Sciences)

UL1TR001881 (NIH – National Center for Advancing Translational Sciences)

UL1TR000040 (NIH – National Center for Advancing Translational Sciences)

KL2TR002490 (NIH – National Center for Advancing Translational Sciences)

UL1RR033176 (NIH – National Center for Research Resources)

R03HL154284 (NIH – National Heart, Lung, and Blood Institute)

R01HL117626 (NIH – National Heart, Lung, and Blood Institute)

U01HL120393 (NIH – National Heart, Lung, and Blood Institute)

U01HL130114 (NIH – National Heart, Lung, and Blood Institute)

R01HL105756 (NIH – National Heart, Lung, and Blood Institute)

R01HL119443 (NIH – National Heart, Lung, and Blood Institute)

R01HL093093 (NIH – National Heart, Lung, and Blood Institute)

R01HL095163 (NIH – National Heart, Lung, and Blood Institute)

R01HL086694 (NIH – National Heart, Lung, and Blood Institute)

P01HL045522 (NIH – National Heart, Lung, and Blood Institute)

R01HL113323 (NIH – National Heart, Lung, and Blood Institute)

R01HL112064 (NIH – National Heart, Lung, and Blood Institute)

R01HL059367 (NIH – National Heart, Lung, and Blood Institute)

R01HL055673 (NIH – National Heart, Lung, and Blood Institute)

R01HL113338 (NIH – National Heart, Lung, and Blood Institute)

R21HL140385 (NIH – National Heart, Lung, and Blood Institute)

R35HL135818 (NIH – National Heart, Lung, and Blood Institute)

R01HL087263 (NIH – National Heart, Lung, and Blood Institute)

R01HL092577 (NIH – National Heart, Lung, and Blood Institute)

R01HL111249 (NIH – National Heart, Lung, and Blood Institute)

R01HL098433 (NIH – National Heart, Lung, and Blood Institute)

R01HL085083 (NIH – National Heart, Lung, and Blood Institute)

K01HL133468 (NIH – National Heart, Lung, and Blood Institute)

R01HL120393 (NIH – National Heart, Lung, and Blood Institute)

R44HL095169 (NIH – National Heart, Lung, and Blood Institute)

R01HL121007 (NIH – National Heart, Lung, and Blood Institute)

R01HL133040 (NIH – National Heart, Lung, and Blood Institute)

K01HL135405 (NIH – National Heart, Lung, and Blood Institute)

R01HL131136 (NIH – National Heart, Lung, and Blood Institute)

R01HL153805 (NIH – National Heart, Lung, and Blood Institute)

R01HL090682 (NIH – National Heart, Lung, and Blood Institute)

U01HL065233 (NIH – National Heart, Lung, and Blood Institute)

R43HL095160 (NIH – National Heart, Lung, and Blood Institute)

R43HL095169 (NIH – National Heart, Lung, and Blood Institute)

R01HL087660 (NIH – National Heart, Lung, and Blood Institute)

R01HL088119 (NIH – National Heart, Lung, and Blood Institute)

R13HL095166 (NIH – National Heart, Lung, and Blood Institute)

R43HL095167 (NIH – National Heart, Lung, and Blood Institute)

R21HL095165 (NIH – National Heart, Lung, and Blood Institute)

R43HL095161 (NIH – National Heart, Lung, and Blood Institute)

R01HL087698 (NIH – National Heart, Lung, and Blood Institute)

R56HG010297 (NIH – National Human Genome Research Institute)

U54HG003273 (NIH – National Human Genome Research Institute)

U01HG007417 (NIH – National Human Genome Research Institute)

R01HG003054 (NIH – National Human Genome Research Institute)

U54HG003067 (NIH – National Human Genome Research Institute)

U24HG008956 (NIH – National Human Genome Research Institute)

UM1HG008898 (NIH – National Human Genome Research Institute)

R01HG011052 (NIH – National Human Genome Research Institute)

R01DK110113 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

U01DK085524 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

P30DK063491 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

R01DK117445 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

R01DK107786 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

P30ES000002 (NIH – National Institute of Environmental Health Sciences)

P20GM109036 (NIH – National Institute of General Medical Sciences)

R01MH078143 (NIH – National Institute of Mental Health)

R01MH083824 (NIH – National Institute of Mental Health)

R01MH078111 (NIH – National Institute of Mental Health)

R01AG023629 (NIH – National Institute On Aging)

R01MD012765 (NIH – National Institute On Minority Health and Health Disparities)

Publication Type:

Article

Unique ID:

10.1186/s12864-022-08356-4

PMID:

35183128

DOI:

10.1186/s12864-022-08356-4

Journal:

BMC Genomics

Publication Date:

2022-12-01

Data Source:

Scopus

Source Link:

View Scopus Record

View OpenAlex Record

View PubMed Record

View Web of Science Record

Record Created:

Thursday, September 12, 2024 - 09:51

Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension

Kelly, T. N., Sun, X., He, K. Y., Brown, M. R., Taliun, S. A. G., Hellwege, J. N., Irvin, M. R., Mi, X., Brody, J. A., Franceschini, N., Guo, X., Hwang, S.-J., de Vries, P. S., Gao, Y., Moscati, A., Nadkarni, G. N., Yanek, L. R., Elfassy, T., … Smith, J. A. (2022). Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension. Hypertension, 79(8), 1656–1667. https://doi.org/10.1161/hypertensionaha.122.19324

Authors:

Tanika N. Kelly

Xiao Sun

Karen Y. He

Michael R. Brown

Sarah A. Gagliano Taliun

Jacklyn N. Hellwege

Marguerite R. Irvin

Xuenan Mi

Jennifer A. Brody

Nora Franceschini

Xiuqing Guo

Shih-Jen Hwang

Paul S. De Vries

Yan Gao

Arden Moscati

Girish N. Nadkarni

Lisa R. Yanek

Tali Elfassy

Jennifer A. Smith

Ren-Hua Chung

Amber L. Beitelshees

Amit Patki

Stella Aslibekyan

Brandon M. Blobner

Juan M. Peralta

Themistocles L. Assimes

Walter R. Palmas

Chunyu Liu

Adam P. Bress

Zhijie Huang

Lewis C. Becker

Chii-Min Hwa

Jeffrey R. O'connell

Jenna C. Carlson

Helen R. Warren

Sayantan Das

Ayush Giri

Lisa W. Martin

W. Craig Johnson

Ervin R. Fox

Erwin P. Bottinger

Alexander C. Razavi

Dhananjay Vaidya

Lee-Ming Chuang

Yen-Pei C. Chang

Take Naseri

Deepti Jain

Hyun Min Kang

Adriana M. Hung

Vinodh Srinivasasainagendra

Beverly M. Snively

Dongfeng Gu

May E. Montasser

Muagututi'a Sefuiva Reupena

Benjamin D. Heavner

Jonathon Lefaive

James E. Hixson

Kenneth M. Rice

Fei Fei Wang

Jonas B. Nielsen

Jianfeng Huang

Alyna T. Khan

Wei Zhou

Jovia L. Nierenberg

Cathy C. Laurie

Nicole D. Armstrong

Mengyao Shi

Yang Pan

Adrienne M. Stilp

Leslie Emery

Quenna Wong

Nicola L. Hawley

Ryan L. Minster

Joanne E. Curran

Patricia B. Munroe

Daniel E. Weeks

Kari E. North

Russell P. Tracy

Eimear E. Kenny

Daichi Shimbo

Aravinda Chakravarti

Stephen S. Rich

Alex P. Reiner

John Blangero

Susan Redline

Braxton D. Mitchell

Dabeeru C. Rao

Yii-Der Ida Chen

Sharon L.R. Kardia

Robert C. Kaplan

Rasika A. Mathias

Jiang He

Bruce M. Psaty

Myriam Fornage

Ruth J.F. Loos

Adolfo Correa

Eric Boerwinkle

Jerome I. Rotter

Charles Kooperberg

Todd L. Edwards

Gonçalo R. Abecasis

Xiaofeng Zhu

Daniel Levy

Donna K. Arnett

Alanna C. Morrison

Affiliated Authors:

Walter R. Palmas

Daichi Shimbo

Columbia Affiliation:

Subjects:

Hypertension (MeSH)

Author Keywords:

allele

blood pressure

genome

hypertension

whole genome sequencing

Grants:

K12HD043483 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)

T32CA160056 (NIH – National Cancer Institute)

T32CA112355 (NIH – National Cancer Institute)

UL1TR001863 (NIH – National Center for Advancing Translational Sciences)

UL1TR003098 (NIH – National Center for Advancing Translational Sciences)

UL1TR001079 (NIH – National Center for Advancing Translational Sciences)

UL1TR000040 (NIH – National Center for Advancing Translational Sciences)

UL1TR001420 (NIH – National Center for Advancing Translational Sciences)

UL1TR001881 (NIH – National Center for Advancing Translational Sciences)

UL1RR033176 (NIH – National Center for Research Resources)

R01HL090682 (NIH – National Heart, Lung, and Blood Institute)

R01HL098433 (NIH – National Heart, Lung, and Blood Institute)

R01HL095163 (NIH – National Heart, Lung, and Blood Institute)

U01HL120393 (NIH – National Heart, Lung, and Blood Institute)

K01HL133468 (NIH – National Heart, Lung, and Blood Institute)

R21HL121429 (NIH – National Heart, Lung, and Blood Institute)

R01HL112064 (NIH – National Heart, Lung, and Blood Institute)

R01HL119443 (NIH – National Heart, Lung, and Blood Institute)

R01HL120393 (NIH – National Heart, Lung, and Blood Institute)

R01HL092577 (NIH – National Heart, Lung, and Blood Institute)

R01HL131136 (NIH – National Heart, Lung, and Blood Institute)

R01HL157635 (NIH – National Heart, Lung, and Blood Institute)

R01HL087263 (NIH – National Heart, Lung, and Blood Institute)

ZIAHL006001 (NIH – National Heart, Lung, and Blood Institute)

R01HL086694 (NIH – National Heart, Lung, and Blood Institute)

R01HL085083 (NIH – National Heart, Lung, and Blood Institute)

U01HL130114 (NIH – National Heart, Lung, and Blood Institute)

R01HL113338 (NIH – National Heart, Lung, and Blood Institute)

R01HL136666 (NIH – National Heart, Lung, and Blood Institute)

R01HL059367 (NIH – National Heart, Lung, and Blood Institute)

R01HL117626 (NIH – National Heart, Lung, and Blood Institute)

R21HL140385 (NIH – National Heart, Lung, and Blood Institute)

R44HL095169 (NIH – National Heart, Lung, and Blood Institute)

R01HL104135 (NIH – National Heart, Lung, and Blood Institute)