K23DK114551

NIH – National Institute of Diabetes and Digestive and Kidney Diseases

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Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

Suzuki, K., Hatzikotoulas, K., Southam, L., Taylor, H. J., Yin, X., Lorenz, K. M., Mandla, R., Huerta-Chagoya, A., Melloni, G. E. M., Kanoni, S., Rayner, N. W., Bocher, O., Arruda, A. L., Sonehara, K., Namba, S., Lee, S. S. K., Preuss, M. H., Petty, L. E., … Schroeder, P. (2024). Genetic drivers of heterogeneity in type 2 diabetes pathophysiology. Nature, 627(8003), 347–357. https://doi.org/10.1038/s41586-024-07019-6
Authors:
Ken Suzuki
Konstantinos Hatzikotoulas
Lorraine Southam
Henry J Taylor
Xianyong Yin
Kim M Lorenz
Ravi Mandla
Alicia Huerta-Chagoya
Giorgio E M Melloni
Stavroula Kanoni
Nigel W Rayner
Ozvan Bocher
Ana Luiza Arruda
Kyuto Sonehara
Shinichi Namba
Simon S K Lee
Michael H Preuss
Lauren E Petty
Philip Schroeder
Brett Vanderwerff
Mart Kals
Fiona Bragg
Kuang Lin
Xiuqing Guo
Weihua Zhang
Jie Yao
Young Jin Kim
Mariaelisa Graff
Fumihiko Takeuchi
Jana Nano
Amel Lamri
Masahiro Nakatochi
Sanghoon Moon
Robert A Scott
James P Cook
Jung-Jin Lee
Ian Pan
Daniel Taliun
Esteban J Parra
Jin-Fang Chai
Lawrence F Bielak
Yasuharu Tabara
Yang Hai
Gudmar Thorleifsson
Niels Grarup
Tamar Sofer
Matthias Wuttke
Chloé Sarnowski
Christian Gieger
Darryl Nousome
Stella Trompet
Soo-Heon Kwak
Jirong Long
Meng Sun
Lin Tong
Wei-Min Chen
Suraj S Nongmaithem
Raymond Noordam
Victor J Y Lim
Claudia H T Tam
Yoonjung Yoonie Joo
Chien-Hsiun Chen
Laura M Raffield
Bram Peter Prins
Aude Nicolas
Lisa R Yanek
Guanjie Chen
Jennifer A Brody
Edmond Kabagambe
Ping An
Anny H Xiang
Hyeok Sun Choi
Brian E Cade
Jingyi Tan
K Alaine Broadaway
Alice Williamson
Zoha Kamali
Jinrui Cui
Manonanthini Thangam
Linda S Adair
Adebowale Adeyemo
Carlos A Aguilar-Salinas
Tarunveer S Ahluwalia
Sonia S Anand
Alain Bertoni
Jette Bork-Jensen
Ivan Brandslund
Thomas A Buchanan
Charles F Burant
Adam S Butterworth
Mickaël Canouil
Juliana C N Chan
Li-Ching Chang
Miao-Li Chee
Ji Chen
Shyh-Huei Chen
Yuan-Tsong Chen
Zhengming Chen
Lee-Ming Chuang
Mary Cushman
John Danesh
Swapan K Das
H Janaka de Silva
George Dedoussis
Latchezar Dimitrov
Ayo P Doumatey
Shufa Du
Qing Duan
Kai-Uwe Eckardt
Leslie S Emery
Daniel S Evans
Michele K Evans
Krista Fischer
James S Floyd
Ian Ford
Oscar H Franco
Timothy M Frayling
Barry I Freedman
Pauline Genter
Hertzel C Gerstein
Vilmantas Giedraitis
Clicerio González-Villalpando
Maria Elena González-Villalpando
Penny Gordon-Larsen
Myron Gross
Lindsay A Guare
Sophie Hackinger
Liisa Hakaste
Sohee Han
Andrew T Hattersley
Christian Herder
Momoko Horikoshi
Annie-Green Howard
Willa Hsueh
Mengna Huang
Wei Huang
Yi-Jen Hung
Mi Yeong Hwang
Chii-Min Hwu
Sahoko Ichihara
Mohammad Arfan Ikram
Martin Ingelsson
Md Tariqul Islam
Masato Isono
Hye-Mi Jang
Farzana Jasmine
Guozhi Jiang
Jost B Jonas
Torben Jørgensen
Frederick K Kamanu
Fouad R Kandeel
Anuradhani Kasturiratne
Tomohiro Katsuya
Varinderpal Kaur
Takahisa Kawaguchi
Jacob M Keaton
Abel N Kho
Chiea-Chuen Khor
Muhammad G Kibriya
Duk-Hwan Kim
Florian Kronenberg
Johanna Kuusisto
Kristi Läll
Leslie A Lange
Kyung Min Lee
Myung-Shik Lee
Nanette R Lee
Aaron Leong
Liming Li
Yun Li
Ruifang Li-Gao
Symen Ligthart
Cecilia M Lindgren
Allan Linneberg
Ching-Ti Liu
Jianjun Liu
Adam E Locke
Tin Louie
Jian'an Luan
Andrea O Luk
Xi Luo
Jun Lv
Julie A Lynch
Valeriya Lyssenko
Shiro Maeda
Vasiliki Mamakou
Sohail Rafik Mansuri
Koichi Matsuda
Thomas Meitinger
Olle Melander
Andres Metspalu
Huan Mo
Andrew D Morris
Filipe A Moura
Jerry L Nadler
Michael A Nalls
Uma Nayak
Ioanna Ntalla
Yukinori Okada
Lorena Orozco
Sanjay R Patel
Snehal Patil
Pei Pei
Mark A Pereira
Annette Peters
Fraser J Pirie
Hannah G Polikowsky
Bianca Porneala
Gauri Prasad
Laura J Rasmussen-Torvik
Alexander P Reiner
Michael Roden
Rebecca Rohde
Katheryn Roll
Charumathi Sabanayagam
Kevin Sandow
Alagu Sankareswaran
Naveed Sattar
Sebastian Schönherr
Mohammad Shahriar
Botong Shen
Jinxiu Shi
Dong Mun Shin
Nobuhiro Shojima
Jennifer A Smith
Wing Yee So
Alena Stančáková
Valgerdur Steinthorsdottir
Adrienne M Stilp
Konstantin Strauch
Kent D Taylor
Barbara Thorand
Unnur Thorsteinsdottir
Brian Tomlinson
Tam C Tran
Fuu-Jen Tsai
Jaakko Tuomilehto
Teresa Tusie-Luna
Miriam S Udler
Adan Valladares-Salgado
Rob M van Dam
Jan B van Klinken
Rohit Varma
Niels Wacher-Rodarte
Eleanor Wheeler
Ananda R Wickremasinghe
Ko Willems van Dijk
Daniel R Witte
Chittaranjan S Yajnik
Ken Yamamoto
Kenichi Yamamoto
Kyungheon Yoon
Canqing Yu
Jian-Min Yuan
Salim Yusuf
Matthew Zawistowski
Liang Zhang
Wei Zheng
Leslie J Raffel
Michiya Igase
Eli Ipp
Susan Redline
Yoon Shin Cho
Lars Lind
Michael A Province
Myriam Fornage
Craig L Hanis
Erik Ingelsson
Alan B Zonderman
Bruce M Psaty
Ya-Xing Wang
Charles N Rotimi
Diane M Becker
Fumihiko Matsuda
Yongmei Liu
Mitsuhiro Yokota
Sharon L R Kardia
Patricia A Peyser
James S Pankow
James C Engert
Amélie Bonnefond
Philippe Froguel
James G Wilson
Wayne H H Sheu
Jer-Yuarn Wu
M Geoffrey Hayes
Ronald C W Ma
Tien-Yin Wong
Dennis O Mook-Kanamori
Tiinamaija Tuomi
Giriraj R Chandak
Francis S Collins
Dwaipayan Bharadwaj
Guillaume Paré
Michèle M Sale
Habibul Ahsan
Ayesha A Motala
Xiao-Ou Shu
Kyong-Soo Park
J Wouter Jukema
Miguel Cruz
Yii-Der Ida Chen
Stephen S Rich
Roberta McKean-Cowdin
Harald Grallert
Ching-Yu Cheng
Mohsen Ghanbari
E-Shyong Tai
Josee Dupuis
Norihiro Kato
Markku Laakso
Anna Köttgen
Woon-Puay Koh
Donald W Bowden
Colin N A Palmer
Jaspal S Kooner
Charles Kooperberg
Simin Liu
Kari E North
Danish Saleheen
Torben Hansen
Oluf Pedersen
Nicholas J Wareham
Juyoung Lee
Bong-Jo Kim
Iona Y Millwood
Robin G Walters
Kari Stefansson
Emma Ahlqvist
Mark O Goodarzi
Karen L Mohlke
Claudia Langenberg
Christopher A Haiman
Ruth J F Loos
Jose C Florez
Daniel J Rader
Marylyn D Ritchie
Sebastian Zöllner
Reedik Mägi
Nicholas A Marston
Christian T Ruff
David A van Heel
Sarah Finer
Joshua C Denny
Toshimasa Yamauchi
Takashi Kadowaki
John C Chambers
Maggie C Y Ng
Xueling Sim
Jennifer E Below
Philip S Tsao
Kyong-Mi Chang
Mark I McCarthy
James B Meigs
Anubha Mahajan
Cassandra N Spracklen
Josep M Mercader
Michael Boehnke
Jerome I Rotter
Marijana Vujkovic
Benjamin F Voight
Andrew P Morris
Eleftheria Zeggini
Affiliated Authors:
Danish Saleheen
Columbia Affiliation:
Subjects:
Diabetes Mellitus, Type 2 (MeSH)
Disease Progression (MeSH)
Genetic Predisposition to Disease (MeSH)
Genome-Wide Association Study (MeSH)
Grants:
R01HD030880 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)
R01HL153805 (NIH – National Heart, Lung, and Blood Institute)
R01HL105756 (NIH – National Heart, Lung, and Blood Institute)
ZIAHG200417 (NIH – National Human Genome Research Institute)
U01HG011723 (NIH – National Human Genome Research Institute)
ZIAHG000024 (NIH – National Human Genome Research Institute)
UM1DK126185 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
U01DK105535 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
R01DK118011 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
UM1DK126194 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
P30DK020572 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
K23DK114551 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
R01DK093757 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
R03DK131249 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
R01DK134575 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
R01DK062370 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
R01DK072193 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
R01DK078150 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
R00AG066849 (NIH – National Institute On Aging)
I01BX003362 (NIH – Veterans Affairs)
Publication Type:
Article
Unique ID:
10.1038/s41586-024-07019-6
PMID:
38374256
DOI:
10.1038/s41586-024-07019-6
Journal:
Nature
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View Scopus Record
View Web of Science Record

Record Created:

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