mTOR Signaling in Growth and Disease

Displaying 1 - 15 of 15CSV
Shin, A. E., Sugiura, K., Kariuki, S. W., Cohen, D. A., Flashner, S. P., Klein-Szanto, A. J., Nishiwaki, N., De, D., Vasan, N., Gabre, J. T., Lengner, C. J., Sims, P. A., & Rustgi, A. K. (2025). LIN28B-mediated PI3K/AKT pathway activation promotes metastasis in colorectal cancer models. Journal of Clinical Investigation. https://doi.org/10.1172/jci186035
Publication Date
Shah, N. N., Wang, M., Roeker, L. E., Patel, K., Woyach, J. A., Wierda, W. G., Ujjani, C. S., Eyre, T. A., Inzani, P. L. Z., Alencar, A. J., Ghia, P., Lamanna, N., Hoffmann, M. S., Patel, M. R., Flinn, I., Gerson, J. N., Ma, S., Coombs, C. C., Cheah, C. Y., … Brown, J. R. (2024). Pirtobrutinib monotherapy in Bruton tyrosine kinase inhibitor-intolerant patients with B-cell malignancies: results of the phase I/II BRUIN trial. Haematologica. https://doi.org/10.3324/haematol.2024.285754
Publication Date
Lamanna, N., Tam, C. S., Woyach, J. A., Alencar, A. J., Palomba, M. L., Zinzani, P. L., Flinn, I. W., Fakhri, B., Cohen, J. B., Kontos, A., Konig, H., Ruppert, A. S., Chatterjee, A., Sizelove, R., Compte, L., Tsai, D. E., & Jurczak, W. (2024). Evaluation of bleeding risk in patients who received pirtobrutinib in the presence or absence of antithrombotic therapy. EJHaem, 5(5), 929–939. Portico. https://doi.org/10.1002/jha2.1013
Publication Date
Zhang, F., Sahu, V., Peng, K., Wang, Y., Li, T., Bala, P., Aitymbayev, D., Sahgal, P., Schaefer, A., Der, C. J., Ryeom, S., Yoon, S., Sethi, N., Bass, A. J., & Zhang, H. (2024). Recurrent RhoGAP gene fusion CLDN18-ARHGAP26 promotes RHOA activation and focal adhesion kinase and YAP-TEAD signalling in diffuse gastric cancer. Gut, 73(8), 1280–1291. https://doi.org/10.1136/gutjnl-2023-329686
Publication Date
Gbadegesin, R., Martinelli, E., Gupta, Y., Friedman, D. J., Sampson, M. G., Pollak, M. R., & Sanna-Cherchi, S. (2024). APOL1 genotyping is incomplete without testing for the protective M1 modifier p.N264K variant. Glomerular Diseases. Portico. https://doi.org/10.1159/000537948
Publication Date
Hijiya, N., Maschan, A., Rizzari, C., Shimada, H., Dufour, C., Goto, H., Kang, H. J., Guinipero, T., Karakas, Z., Bautista, F., Ducassou, S., Yoo, K. H., Zwaan, C. M., Millot, F., Patterson, B. C., Samis, J., Izquierdo, M., Titorenko, K., Li, S., & Sosothikul, D. (2023). The long-term efficacy and safety of nilotinib in pediatric patients with CML: a 5-year update of the DIALOG study. Blood Advances, 7(23), 7279–7289. https://doi.org/10.1182/bloodadvances.2023010122
Publication Date
Le, X., Patel, J., Shum, E., Sanborn, R. E., Baik, C. S., Shu, C. A., Kim, C., Fidler, M. D., Hall, R., Hanna, N., Mohindra, N., Sabari, J. K., Heeke, S., Hernandez, M., Gray, J. E., Heymach, J. V., & Saltos, A. (2023). LBA71 A multi-centre open-label randomized phase II study of osimertinib with and without ramucirumab in TKI-naïve EGFR-mutant metastatic NSCLC (RAMOSE trial interim analysis). Annals of Oncology, 34, S1313–S1314. https://doi.org/10.1016/j.annonc.2023.10.072
Publication Date
Lamanna, N., Tam, C., Jurczak, W., Kontos, A., Konig, H., Ruppert, A., Tsai, D., & Scheliga, A. (2023). COMPARISON OF BLEEDING-RELATED EVENTS IN PATIENTS WHO RECEIVED PIRTOBRUTINIB WITH AND WITHOUT ANTITHROMBOTIC AGENTS. Hematology, Transfusion and Cell Therapy, 45, S161. https://doi.org/10.1016/j.htct.2023.09.359
Publication Date
Thummalapalli, R., Bernstein, E., Herzberg, B., Li, B. T., Iqbal, A., Preeshagul, I., Santini, F. C., Eng, J., Ladanyi, M., Yang, S.-R., Shen, R., Lito, P., Riely, G. J., Sabari, J. K., & Arbour, K. C. (2023). Clinical and Genomic Features of Response and Toxicity to Sotorasib in a Real-World Cohort of Patients With Advanced KRAS G12C-Mutant Non–Small Cell Lung Cancer. JCO Precision Oncology, 7. https://doi.org/10.1200/po.23.00030
Publication Date
Sivakumar, S., Jin, D. X., Rathod, R., Ross, J., Cantley, L. C., Scaltriti, M., Chen, J. W., Hutchinson, K. E., Wilson, T. R., Sokol, E. S., & Vasan, N. (2023). Genetic Heterogeneity and Tissue-specific Patterns of Tumors with MultiplePIK3CAMutations. Clinical Cancer Research, 29(6), 1125–1136. https://doi.org/10.1158/1078-0432.ccr-22-2270
Publication Date
Li, T., Kikuchi, O., Zhou, J., Wang, Y., Pokharel, B., Bastl, K., Gokhale, P., Knott, A., Zhang, Y., Doench, J. G., Ho, Z. V., Catenacci, D. V. T., & Bass, A. J. (2023). Developing SHP2-based combination therapy for KRAS-amplified cancer. JCI Insight, 8(3). https://doi.org/10.1172/jci.insight.152714
Publication Date
Ilozumba, M. N., Yao, S., Llanos, A. A. M., Omilian, A. R., Zhang, W., Datta, S., Hong, C.-C., Davis, W., Khoury, T., Bandera, E. V., Higgins, M., Ambrosone, C. B., & Cheng, T.-Y. D. (2022). mTOR pathway gene expression in association with race and clinicopathological characteristics in Black and White breast cancer patients. Discover Oncology, 13(1). https://doi.org/10.1007/s12672-022-00497-y
Publication Date
Wang, Y., Spolitu, S., Zadroga, J. A., Sarecha, A. K., & Ozcan, L. (2022). Hepatocyte Rap1a contributes to obesity- and statin-associated hyperglycemia. Cell Reports, 40(8), 111259. https://doi.org/10.1016/j.celrep.2022.111259
Publication Date
Pal, I., Grilo, A. M. S., Gaspary, A., Das Sharma, S., Scotto, L., O’Connor, O. A., Jovanovic, M., Deng, C., & Berchowitz, L. E. (2022). Inhibition of casein kinase 1δ disrupts translation initiation and exerts potent antilymphoma activity. Blood Advances, 6(14), 4157–4161. https://doi.org/10.1182/bloodadvances.2021006833
Publication Date