Diagnosis and Management of Eosinophilic Esophagitis

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Bröms, G., Forss, A., Eriksson, J., Askling, J., Eriksson, C., Halfvarson, J., Linder, M., Sun, J., Westerlund, E., Ludvigsson, J. F., & Olén, O. (2025). Adult-onset inflammatory bowel disease and the risk of venous thromboembolism – a Swedish nationwide cohort study 2007–2021. Scandinavian Journal of Gastroenterology, 1–10. https://doi.org/10.1080/00365521.2025.2488053
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Shirley, S., Ichise, H., Di Natale, V., Jin, J., Wu, C., Zou, R., Zhang, W., Fang, Y., Zhang, Y., Chen, M., Peng, S., Basu, U., Que, J., & Huang, Y. (2025). A vasculature-resident innate lymphoid cell population in mouse lungs. Nature Communications, 16(1). https://doi.org/10.1038/s41467-025-58982-1
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Dellon, E. S., Katzka, D. A., Mukkada, V. A., Collins, M. H., Falk, G. W., Richmond, C. A., Terreri, B., Thakur, M., Boules, M., Goodwin, B., & Hirano, I. (2025). Long-Term Safety and Efficacy of Budesonide Oral Suspension for Eosinophilic Esophagitis: a 4-Year, Phase 3, Open-Label Study. Clinical Gastroenterology and Hepatology. https://doi.org/10.1016/j.cgh.2024.12.024
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Dellon, E. S., Muir, A. B., Katzka, D. A., Shah, S. C., Sauer, B. G., Aceves, S. S., Furuta, G. T., Gonsalves, N., & Hirano, I. (2025). ACG Clinical Guideline: Diagnosis and Management of Eosinophilic Esophagitis. American Journal of Gastroenterology, 120(1), 31–59. https://doi.org/10.14309/ajg.0000000000003194
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Yanover, C., Magen-Rimon, R., Voss, E. A., Swerdel, J., Sheahan, A., Hall, N., Park, J., Park, R. W., Lee, K. J., Shin, S. J., Seo, S. I., Lee, K.-J., Falconer, T., Haas, L., Nagy, P., Bowring, M. G., Cook, M., Miller, S., El-Hay, T., … Weisshof, R. (2024). Characteristics and Outcomes of Over a Million Patients with Inflammatory Bowel Disease in Seven Countries: Multinational Cohort Study and Open Data Resource. Digestive Diseases and Sciences. https://doi.org/10.1007/s10620-024-08787-x
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Paulrasu, K., Gokulan, R. C., El-Rifai, W., Chen, Z., Que, J., Wang, T. C., Boutaud, O. G., Briegel, K., Dikalov, S. I., Garcia-Buitrago, M. T., & Zaika, A. I. (2024). Chronic gastroesophageal reflux dysregulates proteostasis in esophageal epithelial cells. Cellular and Molecular Gastroenterology and Hepatology, 101434. https://doi.org/10.1016/j.jcmgh.2024.101434
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Hirano, I., Collins, M. H., Katzka, D. A., Mukkada, V. A., Falk, G. W., Terreri, B., Boules, M., Zhang, W., Desai, N. K., & Dellon, E. S. (2024). Effect of Esophageal Dilation History on Efficacy Outcomes in Patients With Eosinophilic Esophagitis Receiving Budesonide Oral Suspension. American Journal of Gastroenterology. https://doi.org/10.14309/ajg.0000000000003197
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D’Antongiovanni, V., Fornai, M., Colucci, R., Nericcio, A., Benvenuti, L., Di Salvo, C., Segnani, C., Pierucci, C., Ippolito, C., Nemeth, Z. H., Haskó, G., Bernardini, N., Antonioli, L., & Pellegrini, C. (2024). Enteric glial NLRP3 inflammasome contributes to gut mucosal barrier alterations in a mouse model of diet‐induced obesity. Acta Physiologica. Portico. https://doi.org/10.1111/apha.14232
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Cadenhead, J. W., Lee, A. R., Nguyen, T. T. T., Lebwohl, B., Green, P. H. R., & Wolf, R. L. (2024). Dietary Adherence to Recommendations among a Cohort of Adults and Teens with Celiac Disease Maintaining a Gluten-Free Diet Compared to a Nationally Representative Sample: A Cross-Sectional Study. Nutrients, 16(18), 3067. https://doi.org/10.3390/nu16183067
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Gold, B. D., Goodwin, B., Davis, K., Sweeney, C., Ziemiecki, R., Jiang, J., Fan, T., Boules, M., Chen, S.-T., & Katzka, D. A. (2024). Satisfaction With and Adherence to Off-Label Corticosteroids in Adolescents and Adults With Eosinophilic Esophagitis. Journal of Clinical Gastroenterology. https://doi.org/10.1097/mcg.0000000000002006
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Schebendach, J. E., Lee, A. R., Gholmie, Y., Wolf, R., Lebwohl, B., & Green, P. H. (2024). Eating disorder symptoms and diagnoses in adults with celiac disease. Japanese Journal of Gastroenterology Research, 4(4). https://doi.org/10.52768/jjgastro/1196
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Eriksson, C., Sun, J., Bryder, M., Bröms, G., Everhov, Å. H., Forss, A., Jernberg, T., Ludvigsson, J. F., & Olén, O. (2024). Impact of inflammatory bowel disease on the risk of acute coronary syndrome: A Swedish Nationwide Cohort Study. Alimentary Pharmacology & Therapeutics, 59(9), 1122–1133. Portico. https://doi.org/10.1111/apt.17932
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Masuda, M. Y., Pyon, G. C., Luo, H., LeSuer, W. E., Putikova, A., Dao, A., Ortiz, D. R., Schulze, A. R., Fritz, N., Kobayashi, T., Iijima, K., Klein-Szanto, A. J., Shimonosono, M., Flashner, S., Morimoto, M., Pai, R. K., Rank, M. A., Nakagawa, H., Kita, H., … Doyle, A. D. (2024). Epithelial overexpression of IL-33 induces eosinophilic esophagitis dependent on IL-13. Journal of Allergy and Clinical Immunology, 153(5), 1355–1368. https://doi.org/10.1016/j.jaci.2024.01.017
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Gold, B. D., Goodwin, B., Davis, K., Sweeney, C., Reynolds, M., Jiang, J., Fan, T., Boules, M., Chen, S.-T., & Katzka, D. A. (2024). Health-Related Quality of Life and Perceived Stigma in Eosinophilic Esophagitis: A Real-World, US, Web-Based Survey. Gastro Hep Advances, 3(8), 1087–1097. https://doi.org/10.1016/j.gastha.2024.07.015
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Mukkada, V. A., Gupta, S. K., Gold, B. D., Dellon, E. S., Collins, M. H., Katzka, D. A., Falk, G. W., Williams, J., Zhang, W., Boules, M., Hirano, I., & Desai, N. K. (2023). Pooled Phase 2 and 3 Efficacy and Safety Data on Budesonide Oral Suspension in Adolescents with Eosinophilic Esophagitis. Journal of Pediatric Gastroenterology & Nutrition, 77(6), 760–768. https://doi.org/10.1097/mpg.0000000000003948
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Clay, S., Alladina, J., Smith, N. P., Visness, C. M., Wood, R. A., O’Connor, G. T., Cohen, R. T., Khurana Hershey, G. K., Kercsmar, C. M., Gruchalla, R. S., Gill, M. A., Liu, A. H., Kim, H., Kattan, M., Bacharier, L. B., Rastogi, D., Rivera-Spoljaric, K., Robison, R. G., Gergen, P. J., … Dapas, M. (2024). Gene-based association study of rare variants in children of diverse ancestries implicates TNFRSF21 in the development of allergic asthma. Journal of Allergy and Clinical Immunology, 153(3), 809–820. https://doi.org/10.1016/j.jaci.2023.10.023
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Sun, J., Roelstraete, B., Svennberg, E., Halfvarson, J., Sundström, J., Forss, A., Olén, O., & Ludvigsson, J. F. (2023). Long-term risk of arrhythmias in patients with inflammatory bowel disease: A population-based, sibling-controlled cohort study. PLOS Medicine, 20(10), e1004305. https://doi.org/10.1371/journal.pmed.1004305
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Balasubramanian, I., Bandyopadhyay, S., Flores, J., Bianchi‐Smak, J., Lin, X., Liu, H., Sun, S., Golovchenko, N. B., Liu, Y., Wang, D., Patel, R., Joseph, I., Suntornsaratoon, P., Vargas, J., Green, P. H., Bhagat, G., Lagana, S. M., Ying, W., Zhang, Y., … Gao, N. (2023). Infection and inflammation stimulate expansion of a CD74+ Paneth cell subset to regulate disease progression. The EMBO Journal, 42(21). Portico. https://doi.org/10.15252/embj.2023113975
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Hirano, I., Dellon, E. S., Gupta, S. K., Katzka, D. A., Collins, M. H., Wojtowicz, A. M., Terreri, B., Zhang, W., Boules, M., Bhatia, S., & Desai, N. K. (2023). Safety of an investigational formulation of budesonide (budesonide oral suspension) for eosinophilic oesophagitis: an integrated safety analysis of six phase 1–3 clinical trials. Alimentary Pharmacology & Therapeutics, 57(10), 1117–1130. Portico. https://doi.org/10.1111/apt.17430
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Mehta, B., Jannat-Khah, D., Glaser, K. K., Luo, Y., Sammaritano, L. R., Branch, D. W., Goodman, S. M., Lockshin, M., Wang, F., Ibrahim, S., & Salmon, J. E. (2023). Fetal and maternal morbidity in pregnant patients with Lupus: a 10-year US nationwide analysis. RMD Open, 9(1), e002752. https://doi.org/10.1136/rmdopen-2022-002752
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Wright, B., Masuda, M., Flashner, S., Gibson, J., Luo, H., Putikova, A., Pyon, G., Rank, M., Nakagawa, H., Kita, H., Cope, E., & Doyle, A. (2023). Oral detergent exposure alters the esophageal microbiome and induces eosinophilic inflammation. Journal of Allergy and Clinical Immunology, 151(2), AB89. https://doi.org/10.1016/j.jaci.2022.12.282
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Lebovits, J., Lee, A. R., Ciaccio, E. J., Wolf, R. L., Davies, R. H., Cerino, C., Lebwohl, B., & Green, P. H. R. (2022). Impact of Celiac Disease on Dating. Digestive Diseases and Sciences, 67(11), 5158–5167. https://doi.org/10.1007/s10620-022-07548-y
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Dellon, E. S., Gonsalves, N., Abonia, J. P., Alexander, J. A., Arva, N. C., Atkins, D., Attwood, S. E., Auth, M. K. H., Bailey, D. D., Biederman, L., Blanchard, C., Bonis, P. A., Bose, P., Bredenoord, A. J., Chang, J. W., Chehade, M., Collins, M. H., Di Lorenzo, C., Dias, J. A., … Aceves, S. S. (2022). International Consensus Recommendations for Eosinophilic Gastrointestinal Disease Nomenclature. Clinical Gastroenterology and Hepatology, 20(11), 2474-2484.e3. https://doi.org/10.1016/j.cgh.2022.02.017
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Nathanson, J. T., Chawla, S., Blackett, J., & Garcia-Carrasquillo, R. J. (2022). S2307 Esophageal Hemorrhage After Transesophageal Echocardiography in a Patient With Undiagnosed Eosinophilic Esophagitis. American Journal of Gastroenterology, 117(10S), e1553–e1553. https://doi.org/10.14309/01.ajg.0000865868.81054.8f
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Tran, P., Gober, L., Garabedian, E. K., Fuleihan, R. L., Puck, J. M., Sullivan, K. E., Spergel, J. M., & Ruffner, M. A. (2022). Eosinophilic gastrointestinal disorders in patients with inborn errors of immunity: Data from the USIDNET registry. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.987895
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Floege, J., Barratt, J., Coppo, R., Lafayette, R., Radhakrishnan, J., Reich, H. N., Rovin, B. H., Selewski, D. T., Vivarelli, M., Pham, C., & Tesař, V. (2022). International Physicians Delphi Survey: Managing Patients With IgA Nephropathy. Kidney International Reports, 7(9), 2076–2080. https://doi.org/10.1016/j.ekir.2022.05.022
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D’Antongiovanni, V., Pellegrini, C., Benvenuti, L., Fornai, M., Di Salvo, C., Natale, G., Ryskalin, L., Bertani, L., Lucarini, E., Di Cesare Mannelli, L., Ghelardini, C., Nemeth, Z. H., Haskó, G., & Antonioli, L. (2022). RETRACTED ARTICLE: Anti-inflammatory Effects of Novel P2X4 Receptor Antagonists, NC-2600 and NP-1815-PX, in a Murine Model of Colitis. Inflammation, 45(4), 1829–1847. https://doi.org/10.1007/s10753-022-01663-8
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Hara, T., Kasagi, Y., Wang, J., Sasaki, M., Aaron, B., Karami, A., Shimonosono, M., Shimonosono, R., Maekawa, H., Dolinsky, L., Wilkins, B., Klein, J., Wei, J., Nunes, K., Lynch, K., Spergel, J. M., Hamilton, K. E., Ruffner, M. A., Karakasheva, T. A., … Muir, A. B. (2022). CD73+ Epithelial Progenitor Cells That Contribute to Homeostasis and Renewal Are Depleted in Eosinophilic Esophagitis. Cellular and Molecular Gastroenterology and Hepatology, 13(5), 1449–1467. https://doi.org/10.1016/j.jcmgh.2022.01.018
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Pannala, R., Krishnan, K., Watson, R. R., Vela, M. F., Abu Dayyeh, B. K., Bhatt, A., Bhutani, M. S., Bucobo, J. C., Chandrasekhara, V., Copland, A. P., Jirapinyo, P., Kumta, N. A., Law, R. J., Maple, J. T., Melson, J., Parsi, M. A., Rahimi, E. F., Saumoy, M., Sethi, A., … Lichtenstein, D. R. (2022). Devices for esophageal function testing. VideoGIE, 7(1), 1–20. https://doi.org/10.1016/j.vgie.2021.08.012
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Yu, K., Faye, A., Wen, T., Guglielminotti, J., Huang, Y., Wright, J. D., D’Alton, M. E., & Friedman, A. M. (2022). Trends in and Outcomes during Delivery Hospitalizations with Inflammatory Bowel Disease. American Journal of Obstetrics and Gynecology, 226(1), S363–S364. https://doi.org/10.1016/j.ajog.2021.11.610
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Teng, F., Tachó-Piñot, R., Sung, B., Farber, D. L., Worgall, S., Hammad, H., Lambrecht, B. N., Hepworth, M. R., & Sonnenberg, G. F. (2021). ILC3s control airway inflammation by limiting T cell responses to allergens and microbes. Cell Reports, 37(8), 110051. https://doi.org/10.1016/j.celrep.2021.110051
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