Role of Retinoic Acid in Biological Processes

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Mannowetz, N., Chung, S. S. W., Maitra, S., Noman, M. A. A., Wong, H. L., Cheryala, N., Bakshi, A., Wolgemuth, D. J., & Georg, G. I. (2025). Targeting the retinoid signaling pathway with YCT-529 for effective and reversible oral contraception in mice and primates. Communications Medicine, 5(1). https://doi.org/10.1038/s43856-025-00752-7
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Hong, J., Sui, P., Li, Y., Xu, K. Y., Lee, J.-H., Wang, J., Chen, S., Zhang, P., Wingate, N., Noor, A., Yuan, Y., Hromas, R., Zhou, H., Hamamoto, K., Su, R., Yin, C. C., Ye, F., Quesada, A. E., Chen, J., … Xu, M. (2025). PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1. Cell Stem Cell. https://doi.org/10.1016/j.stem.2025.01.010
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Ramkumar, S., Jastrzebska, B., Montenegro, D., Sparrow, J. R., & von Lintig, J. (2024). Unraveling the mystery of ocular retinoid turnover: Insights from albino mice and the role of STRA6. Journal of Biological Chemistry, 300(3), 105781. https://doi.org/10.1016/j.jbc.2024.105781
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Kim, H. J., Zhao, J., Walewski, J. L., & Sparrow, J. R. (2023). A high fat diet fosters elevated bisretinoids. Journal of Biological Chemistry, 299(6), 104784. https://doi.org/10.1016/j.jbc.2023.104784
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de Botton, S., Cluzeau, T., Vigil, C., Cook, R. J., Rousselot, P., Rizzieri, D. A., Liesveld, J. L., Fenaux, P., Braun, T., Banos, A., Jurcic, J. G., Sekeres, M. A., Savona, M. R., Roboz, G. J., Bixby, D., Madigan, K., Volkert, A., Stephens, K., Kang-Fortner, Q., … Stein, E. M. (2023). Targeting RARA overexpression with tamibarotene, a potent and selective RARα agonist, is a novel approach in AML. Blood Advances, 7(9), 1858–1870. https://doi.org/10.1182/bloodadvances.2022008806
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Montenegro, D., Zhao, J., Kim, H. J., Shmarakov, I. O., Blaner, W. S., & Sparrow, J. R. (2022). Products of the visual cycle are detected in mice lacking retinol binding protein 4, the only known vitamin A carrier in plasma. Journal of Biological Chemistry, 298(12), 102722. https://doi.org/10.1016/j.jbc.2022.102722
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Kim, H. J., Zhao, J., & Sparrow, J. R. (2022). Vitamin A aldehyde-taurine adducts function in photoreceptor cells. Redox Biology, 54, 102386. https://doi.org/10.1016/j.redox.2022.102386
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