Metabolic Reprogramming in Cancer Biology

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Yarchoan, M., Powderly, J. D., Bastos, B. R., Karasic, T. B., Crysler, O. V., Munster, P. N., McKean, M. A., Emens, L. A., Saenger, Y. M., Ged, Y., Stagg, R., Smith, S., Whiting, C. C., Moon, A., Prasit, P., Jenkins, Y., Standifer, N., Dubensky, T. W., Whiting, S. H., & Ulahannan, S. V. (2024). First-in-human Phase I Trial of TPST-1120, an Inhibitor of PPARα, as Monotherapy or in Combination with Nivolumab, in Patients with Advanced Solid Tumors. Cancer Research Communications, 4(4), 1100–1110. https://doi.org/10.1158/2767-9764.crc-24-0082
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Ross, A. B., Gorhe, D., Kim, J. K., Hodapp, S., DeVine, L., Chan, K. M., Chio, I. I. C., Jovanovic, M., & Ayres Pereira, M. (2024). Systematic analysis of proteome turnover in an organoid model of pancreatic cancer by dSILO. Cell Reports Methods, 4(5), 100760. https://doi.org/10.1016/j.crmeth.2024.100760
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Nguyen, T. T. T., Torrini, C., Shang, E., Shu, C., Mun, J.-Y., Gao, Q., Humala, N., Akman, H. O., Zhang, G., Westhoff, M.-A., Karpel-Massler, G., Bruce, J. N., Canoll, P., & Siegelin, M. D. (2024). OGDH and Bcl-xL loss causes synthetic lethality in glioblastoma. JCI Insight. https://doi.org/10.1172/jci.insight.172565
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Lee, I. Y., Hanft, S., Schulder, M., Judy, K. D., Wong, E. T., Elder, J. B., Evans, L. T., Zuccarello, M., Wu, J., Aulakh, S., Agarwal, V., Ramakrishna, R., Gill, B. J., Quiñones-Hinojosa, A., Brennan, C., Zacharia, B. E., Silva Correia, C. E., Diwanji, M., Pennock, G. K., … Boockvar, J. A. (2024). Autologous Cell Immunotherapy (IGV-001) with IGF-1R Antisense Oligonucleotide in Newly Diagnosed Glioblastoma Patients. Future Oncology, 20(10), 579–591. https://doi.org/10.2217/fon-2023-0702
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Chen, F., Tang, C., Yang, F., Ekpenyong, A., Qin, R., Xie, J., Momen-Heravi, F., Saba, N. F., & Teng, Y. (2024). HSP90 inhibition suppresses tumor glycolytic flux to potentiate the therapeutic efficacy of radiotherapy for head and neck cancer. Science Advances, 10(8). https://doi.org/10.1126/sciadv.adk3663
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Ali, S. R., Nguyen, N. U. N., Menendez-Montes, I., Hsu, C.-C., Elhelaly, W., Lam, N. T., Li, S., Elnwasany, A., Nakada, Y., Thet, S., Foo, R. S. Y., & Sadek, H. A. (2024). Hypoxia-induced stabilization of HIF2A promotes cardiomyocyte proliferation by attenuating DNA damage. The Journal of Cardiovascular Aging, 4(1). https://doi.org/10.20517/jca.2023.43
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Picca, A., Di Stefano, A. L., Savatovsky, J., Ducray, F., Chinot, O., Moyal, E. C.-J., Augereau, P., Le Rhun, E., Schmitt, Y., Rousseaux, N., Yepnang, A. M. M., Estellat, C., Charbonneau, F., Letourneur, Q., Branger, D. F., Meyronet, D., Fardeau, C., Mokhtari, K., Bielle, F., … Sanson, M. (2024). TARGET: A phase I/II open-label multicenter study to assess safety and efficacy of fexagratinib in patients with relapsed/refractory FGFR fusion-positive glioma. Neuro-Oncology Advances, 6(1). https://doi.org/10.1093/noajnl/vdae068
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Columbia Affiliation
Li, A. M., He, B., Karagiannis, D., Li, Y., Jiang, H., Srinivasan, P., Ramirez, Y., Zhou, M.-N., Curtis, C., Gruber, J. J., Lu, C., Rankin, E. B., & Ye, J. (2023). Serine starvation silences estrogen receptor signaling through histone hypoacetylation. Proceedings of the National Academy of Sciences, 120(38). https://doi.org/10.1073/pnas.2302489120
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Fernandez Garcia, E., Paudel, U., Noji, M. C., Bowman, C. E., Rustgi, A. K., Pitarresi, J. R., Wellen, K. E., Arany, Z., Weissenrieder, J. S., & Foskett, J. K. (2023). The mitochondrial Ca2+ channel MCU is critical for tumor growth by supporting cell cycle progression and proliferation. Frontiers in Cell and Developmental Biology, 11. https://doi.org/10.3389/fcell.2023.1082213
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Boboila, S., Okochi, S., Banerjee, D., Barton, S., Street, C., Zenilman, A. L., Wang, Q., Gartrell, R. D., Saenger, Y. M., Welch, D., Wu, C.-C., Kadenhe-Chiweshe, A., Yamashiro, D. J., & Connolly, E. P. (2023). Combining immunotherapy with high-dose radiation therapy (HDRT) significantly inhibits tumor growth in a syngeneic mouse model of high-risk neuroblastoma. Heliyon, 9(6), e17399. https://doi.org/10.1016/j.heliyon.2023.e17399
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Shang, E., Nguyen, T. T. T., Westhoff, M.-A., Karpel-Massler, G., & Siegelin, M. D. (2023). Targeting cellular respiration as a therapeutic strategy in glioblastoma. Oncotarget, 14(1), 419–425. https://doi.org/10.18632/oncotarget.28424
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Lemmetyinen, T. T., Viitala, E. W., Wartiovaara, L., Kaprio, T., Hagström, J., Haglund, C., Katajisto, P., Wang, T. C., Domènech-Moreno, E., & Ollila, S. (2023). Fibroblast-derived EGF ligand neuregulin 1 induces fetal-like reprogramming of the intestinal epithelium without supporting tumorigenic growth. Disease Models & Mechanisms, 16(4). https://doi.org/10.1242/dmm.049692
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Garcia, J. A., Chen, R., Xu, M., Comerford, S. A., Hammer, R. E., Melton, S. D., & Feagins, L. A. (2023). Acss2/HIF-2 signaling facilitates colon cancer growth and metastasis. PLOS ONE, 18(3), e0282223. https://doi.org/10.1371/journal.pone.0282223
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Tasic, L., Avramović, N., Jadranin, M., Quintero, M., Stanisic, D., Martins, L. G., Costa, T. B. B. C., Novak, E., Odone, V., Rivas, M., Aguiar, T., Carraro, D. M., Werneck da Cunha, I., Lima da Costa, C. M., Maschietto, M., & Krepischi, A. (2022). High-Resolution Magic-Angle-Spinning NMR in Revealing Hepatoblastoma Hallmarks. Biomedicines, 10(12), 3091. https://doi.org/10.3390/biomedicines10123091
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Filippone, M. G., Gaglio, D., Bonfanti, R., Tucci, F. A., Ceccacci, E., Pennisi, R., Bonanomi, M., Jodice, G., Tillhon, M., Montani, F., Bertalot, G., Freddi, S., Vecchi, M., Taglialatela, A., Romanenghi, M., Romeo, F., Bianco, N., Munzone, E., Sanguedolce, F., … Pece, S. (2022). CDK12 promotes tumorigenesis but induces vulnerability to therapies inhibiting folate one-carbon metabolism in breast cancer. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-30375-8
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Baran, N., Lodi, A., Dhungana, Y., Herbrich, S., Collins, M., Sweeney, S., Pandey, R., Skwarska, A., Patel, S., Tremblay, M., Kuruvilla, V. M., Cavazos, A., Kaplan, M., Warmoes, M. O., Veiga, D. T., Furudate, K., Rojas-Sutterin, S., Haman, A., Gareau, Y., … Konopleva, M. (2022). Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-30396-3
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Pan, P., Haggiagi, A., & Iwamoto, F. (2022). BIOM-12. PROLONGED RESPONSE TO THIRD-LINE TREATMENT WITH COMBINATION CCNU/TMZ IN AN MGMT METHYLATED IDH-WILDTYPE GLIOBLASTOMA. Neuro-Oncology, 24(Supplement_7), vii6–vii6. https://doi.org/10.1093/neuonc/noac209.022
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Iwamoto, F., Polley, M.-Y., Shaw, E., Buckner, J., Barger, G., Coons, S., Ricci, P., Gilbert, M., Brown, P., Stelzer, K., Rogers, C. L., Suh, J., Schultz, C., Howard, S., Fisher, B., Kim, M., Huang, J., Haddock, M., Won, M., & Mehta, M. (2022). CTNI-16. NRG-RTOG 9802 OBSERVATION ARM - LONG TERM RESULT. Neuro-Oncology, 24(Supplement_7), vii73–vii73. https://doi.org/10.1093/neuonc/noac209.282
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Arrillaga-Romany, I., Lassman, A., McGovern, S., Mueller, S., Nabors, L. B., van den Bent, M., Vogelbaum, M., Allen, J. E., Melemed, A., Tarapore, R., Yang, D., Wen, P. Y., & Cloughesy, T. (2022). RTID-01. ONC108: A RANDOMIZED PHASE 3 STUDY OF ONC201 IN PATIENTS WITH NEWLY DIAGNOSED H3 K27M-MUTANT DIFFUSE GLIOMA. Neuro-Oncology, 24(Supplement_7), vii249–vii249. https://doi.org/10.1093/neuonc/noac209.961
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Oh, M., Hasanain, M., Migliozzi, S., Garofano, L., D’Angelo, F., Stefano, A. L. D., Lerond, J., Sarkaria, J., Ceccarelli, M., Sanson, M., Lasorella, A., & Iavarone, A. (2022). EXTH-21. DEVELOPMENT OF THERAPEUTIC STRATEGIES BY PATHWAY-BASED MULTI-OMICS APPROACH AND MASTER KINASE ANALYSIS IN GLIOBLASTOMA MULTIFORME. Neuro-Oncology, 24(Supplement_7), vii214–vii214. https://doi.org/10.1093/neuonc/noac209.820
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He, D., Feng, H., Sundberg, B., Yang, J., Powers, J., Christian, A. H., Wilkinson, J. E., Monnin, C., Avizonis, D., Thomas, C. J., Friedman, R. A., Kluger, M. D., Hollingsworth, M. A., Grandgenett, P. M., Klute, K. A., Toste, F. D., Chang, C. J., & Chio, I. I. C. (2022). Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis. Molecular Cell, 82(16), 3045-3060.e11. https://doi.org/10.1016/j.molcel.2022.06.005
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Arrillaga-Romany, I., Kurz, S., Tarapore, R., Lu, G., Sumrall, A., Butowski, N., Harrison, R., DeGroot, J., Chi, A., Shonka, N., Umemura, Y., Odia, Y., Mehta, M., Nghiemphu, P., Cloughesy, T., Taylor, L., Graber, J., Kilburn, L., Dixit, K., … Wen, P. (2022). SYST-14 CLINICAL EFFICACY OF ONC201 IN RECURRENT H3 K27M-MUTANT DIFFUSE MIDLINE GLIOMA (DMG) PATIENTS. Neuro-Oncology Advances, 4(Supplement_1), i24–i24. https://doi.org/10.1093/noajnl/vdac078.093
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Torrini, C., Nguyen, T. T. T., Shu, C., Mela, A., Humala, N., Mahajan, A., Seeley, E. H., Zhang, G., Westhoff, M.-A., Karpel-Massler, G., Bruce, J. N., Canoll, P., & Siegelin, M. D. (2022). Lactate is an epigenetic metabolite that drives survival in model systems of glioblastoma. Molecular Cell, 82(16), 3061-3076.e6. https://doi.org/10.1016/j.molcel.2022.06.030
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Trudeau, T., Prince, E., Chatain, O., Chee, K., Jackson, E., Limbrick, D., Naftel, R., Feldstein, N., Grant, G., Ginn, K., Niazi, T., Smith, A., Kilburn, L., Chern, J., Drapeau, A., Lam, S., Johnston, J., Dudley, R., Staulcup, S., & Hankinson, T. (2022). RARE-24. The use of novelin vitro models to study adamantinomatous craniopharyngioma disease biology and drug response. Neuro-Oncology, 24(Supplement_1), i15–i15. https://doi.org/10.1093/neuonc/noac079.049
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Nguyen, T. T. T., Shang, E., Schiffgens, S., Torrini, C., Shu, C., Akman, H. O., Prabhu, V. V., Allen, J. E., Westhoff, M.-A., Karpel-Massler, G., & Siegelin, M. D. (2022). Induction of Synthetic Lethality by Activation of Mitochondrial ClpP and Inhibition of HDAC1/2 in Glioblastoma. Clinical Cancer Research, 28(9), 1881–1895. https://doi.org/10.1158/1078-0432.ccr-21-2857
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Lu, H., Gomaa, A., Wang-Bishop, L., Ballout, F., Hu, T., McDonald, O., Washington, M. K., Livingstone, A. S., Wang, T. C., Peng, D., El-Rifai, W., & Chen, Z. (2022). Unfolded Protein Response Is Activated by Aurora Kinase A in Esophageal Adenocarcinoma. Cancers, 14(6), 1401. https://doi.org/10.3390/cancers14061401
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