Engineering Bacteria for Cancer Treatment

Displaying 1 - 24 of 24CSV
Sharma, M. R., Johnson, M. L., Puzanov, I., Sznol, M., Mckean, M., Gainor, J. F., Spira, A., Henick, B., Tolcher, A. W., Chen, C. T., El-Khoueiry, A., Broderick, J., Peng, L., Che, J., Cao, L., Wilson, D., Lathers, D., Horak, C., Feltquate, D., & Luke, J. J. (2024). 758 GLIMMER-01: phase 1/2 trial of a first-in-class bi-sialidase (E-602) in combination with cemiplimab in patients with PD-(L)1-resistant solid tumors. Regular and Young Investigator Award Abstracts, A862–A862. https://doi.org/10.1136/jitc-2024-sitc2024.0758
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Li, F., Yang, Z., Savage, T. M., Vincent, R. L., de los Santos-Alexis, K., Ahn, A., Rouanne, M., Mariuzza, D. L., Danino, T., & Arpaia, N. (2024). Programmable bacteria synergize with PD-1 blockade to overcome cancer cell–intrinsic immune resistance mechanisms. Science Immunology, 9(100). https://doi.org/10.1126/sciimmunol.adn9879
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Redenti, A., Im, J., Redenti, B., Li, F., Rouanne, M., Sheng, Z., Sun, W., Gurbatri, C. R., Huang, S., Komaranchath, M., Jang, Y., Hahn, J., Ballister, E. R., Vincent, R. L., Vardoshivilli, A., Danino, T., & Arpaia, N. (2024). Probiotic neoantigen delivery vectors for precision cancer immunotherapy. Nature, 635(8038), 453–461. https://doi.org/10.1038/s41586-024-08033-4
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Liguori, F., Pellicciotta, N., Milanetti, E., Xi Windemuth, S., Ruocco, G., Di Leonardo, R., & Danino, T. (2024). Dynamic Gene Expression Mitigates Mutational Escape in Lysis-Driven Bacteria Cancer Therapy. BioDesign Research, 6. https://doi.org/10.34133/bdr.0049
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Lee, I. Y., Hanft, S., Schulder, M., Judy, K. D., Wong, E. T., Elder, J. B., Evans, L. T., Zuccarello, M., Wu, J., Aulakh, S., Agarwal, V., Ramakrishna, R., Gill, B. J., Quiñones-Hinojosa, A., Brennan, C., Zacharia, B. E., Silva Correia, C. E., Diwanji, M., Pennock, G. K., … Boockvar, J. A. (2024). Autologous Cell Immunotherapy (IGV-001) with IGF-1R Antisense Oligonucleotide in Newly Diagnosed Glioblastoma Patients. Future Oncology, 20(10), 579–591. https://doi.org/10.2217/fon-2023-0702
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Gurbatri, C. R., Radford, G. A., Vrbanac, L., Im, J., Thomas, E. M., Coker, C., Taylor, S. R., Jang, Y., Sivan, A., Rhee, K., Saleh, A. A., Chien, T., Zandkarimi, F., Lia, I., Lannagan, T. R. M., Wang, T., Wright, J. A., Kobayashi, H., Ng, J. Q., … Danino, T. (2024). Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-44776-4
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Okolo, O., Honzel, E., Britton, W. R., Yu, V. X., Flashner, S., Martin, C., Nakagawa, H., & Parikh, A. S. (2023). Experimental Modeling of Host–Bacterial Interactions in Head and Neck Squamous Cell Carcinoma. Cancers, 15(24), 5810. https://doi.org/10.3390/cancers15245810
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O’Cearbhaill, R. E., Moore, K. N., Yeku, O., Liu, J. F., Bouberhan, S., Hamilton, E. P., Hou, J. Y., Van Nieuwenhuysen, E., Papadimitriou, K., Yoo, S.-Y., Govindraj, S., Brouwer-Visser, J., Peterman, M., Schmidt, T., Barnes, B., Madia, P., Zhu, M., Uldrick, T. S., Miller, E. A., & O’Malley, D. (2023). 754P Ubamatamab (MUC16xCD3 bispecific antibody) with cemiplimab (anti-PD-1 antibody) in recurrent ovarian cancer: Phase I dose-escalation study. Annals of Oncology, 34, S516–S517. https://doi.org/10.1016/j.annonc.2023.09.1933
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Kokossis, D., Wei, H.-J., Gallitto, M., Yoh, N., McQuillan, N., Tazhibi, M., Berg, X., Zhang, X., Szalontay, L., Gartrell, R. D., Pavisic, J., Zhang, Z., Molotkov, A., Mintz, A., Konofagou, E. E., & Wu, C.-C. (2023). SURG-06. ENHANCED DELIVERY OF ANTI-PD1 FOR TREATMENT OF DIFFUSE MIDLINE GLIOMA USING FOCUSED ULTRASOUND-MEDIATED BLOOD-BRAIN BARRIER OPENING. Neuro-Oncology, 25(Supplement_1), i73–i73. https://doi.org/10.1093/neuonc/noad073.282
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Wang, Y.-C., Kelso, A. A., Karamafrooz, A., Chen, Y.-H., Chen, W.-K., Cheng, C.-T., Qi, Y., Gu, L., Malkas, L., Taglialatela, A., Kung, H.-J., Moldovan, G.-L., Ciccia, A., Stark, J. M., & Ann, D. K. (2023). Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination. Cell Reports, 42(4), 112296. https://doi.org/10.1016/j.celrep.2023.112296
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Savage, T. M., Vincent, R. L., Rae, S. S., Huang, L. H., Ahn, A., Pu, K., Li, F., de los Santos-Alexis, K., Coker, C., Danino, T., & Arpaia, N. (2023). Chemokines expressed by engineered bacteria recruit and orchestrate antitumor immunity. Science Advances, 9(10). https://doi.org/10.1126/sciadv.adc9436
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Fine, R. L., Mao, Y., Garcia-Carracedo, D., Su, G. H., Qiu, W., Hochfeld, U., Nichols, G., Li, Y.-L., Dinnen, R. D., Raffo, A., & Brandt-Rauf, P. W. (2023). Gene Therapy with p14/tBID Induces Selective and Synergistic Apoptosis in Mutant Ras and Mutant p53 Cancer Cells In Vitro and In Vivo. Biomedicines, 11(2), 258. https://doi.org/10.3390/biomedicines11020258
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Hsu, D. J., Gao, J., Yamaguchi, N., Pinzaru, A., Wu, Q., Mandayam, N., Liberti, M., Heissel, S., Alwaseem, H., Tavazoie, S., & Tavazoie, S. F. (2023). Arginine limitation drives a directed codon-dependent DNA sequence evolution response in colorectal cancer cells. Science Advances, 9(1). https://doi.org/10.1126/sciadv.ade9120
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Deb, D., Wu, Y., Coker, C., Harimoto, T., Huang, R., & Danino, T. (2022). Design of combination therapy for engineered bacterial therapeutics in non-small cell lung cancer. Scientific Reports, 12(1). https://doi.org/10.1038/s41598-022-26105-1
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Wen, P. Y., Reardon, D. A., Forst, D., Lee, E., Daoud, T., Berthoud, T., Soare, C., Diaz-Mitoma, F., Anderson, D. E., Lassman, A., & Iwamoto, F. (2022). CTIM-14. COMPREHENSIVE BIOMARKER ANALYSIS OF RESPONDERS AND NON-RESPONDERS IN A PHASE IIA TRIAL OF A CMV VACCINE IMMUNOTHERAPEUTIC CANDIDATE (VBI-1901). Neuro-Oncology, 24(Supplement_7), vii62–vii62. https://doi.org/10.1093/neuonc/noac209.246
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Sharma, M., Lathers, D., Johnson, M., Luke, J., Puzanov, I., Curti, B., Chen, C., El-Khoueiry, A., Henick, B., Callahan, M., Sznol, M., Patel, S., Wilson, D., Ricker, M., Cao, L., Jayaraman, P., Che, J., Peng, L., Feltquate, D., … Tolcher, A. (2022). 772 A phase 1/2 dose escalation/expansion study evaluating the safety, pharmacokinetics, pharmacodynamics, and antitumor activity of E-602, a bi-sialidase fusion protein, in advanced cancer (GLIMMER-01). Regular and Young Investigator Award Abstracts, A803–A803. https://doi.org/10.1136/jitc-2022-sitc2022.0772
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Park, K. W., Yang, H., Lee, M. G., Ock, S. A., Wi, H., Lee, P., Hwang, I.-S., Yoo, J. G., Park, C.-K., & Lee, B. R. (2022). Establishment of intestinal organoids from small intestine of growing cattle (12 months old). Journal of Animal Science and Technology, 64(6), 1105–1116. https://doi.org/10.5187/jast.2022.e70
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Iwamoto, F., Tanguturi, S., Desai, A., Nayak, L., Uhlmann, E., Wang, T., Lustig, R., Hertan, L., Bagley, S., Hayden, J., Laforest-Roys, C., Muzikansky, A., McCluskey, C., Chukwueke, U., McFaline-Figueroa, J. R., Lee, E., Wen, P. Y., & Reardon, D. (2022). CTIM-18. PHASE 2 STUDY OF PD-1 BLOCKADE WITH PEMBROLIZUMAB PLUS RE-IRRADIATION FOR RECURRENT GLIOBLASTOMA (RGBM) (NCT03661723). Neuro-Oncology, 24(Supplement_7), vii63–vii64. https://doi.org/10.1093/neuonc/noac209.250
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Pan, P., Haggiagi, A., & Iwamoto, F. (2022). BIOM-12. PROLONGED RESPONSE TO THIRD-LINE TREATMENT WITH COMBINATION CCNU/TMZ IN AN MGMT METHYLATED IDH-WILDTYPE GLIOBLASTOMA. Neuro-Oncology, 24(Supplement_7), vii6–vii6. https://doi.org/10.1093/neuonc/noac209.022
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Liau, L. M., Ashkan, K., Brem, S., Campian, J., Trusheim, J., Iwamoto, F., Tran, D., Anstass, G., Cobbs, C., Heth, J., Salacz, M., D’Andre, S., Aiken, R., Moshel, Y., Nam, J., Pillainayagam, C., Wagner, S., Walter, K., Chaudary, R., … Bosch, M. (2022). CTIM-27. AUTOLOGOUS TUMOR LYSATE-LOADED DENDRITIC CELL VACCINATION IMPROVES SURVIVAL IN PATIENTS WITH NEWLY DIAGNOSED AND RECURRENT GLIOBLASTOMA: SURVIVAL RESULTS FROM A PHASE 3 TRIAL. Neuro-Oncology, 24(Supplement_7), vii66–vii66. https://doi.org/10.1093/neuonc/noac209.259
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He, D., Feng, H., Sundberg, B., Yang, J., Powers, J., Christian, A. H., Wilkinson, J. E., Monnin, C., Avizonis, D., Thomas, C. J., Friedman, R. A., Kluger, M. D., Hollingsworth, M. A., Grandgenett, P. M., Klute, K. A., Toste, F. D., Chang, C. J., & Chio, I. I. C. (2022). Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis. Molecular Cell, 82(16), 3045-3060.e11. https://doi.org/10.1016/j.molcel.2022.06.005
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Arrillaga-Romany, I., Kurz, S., Tarapore, R., Lu, G., Sumrall, A., Butowski, N., Harrison, R., DeGroot, J., Chi, A., Shonka, N., Umemura, Y., Odia, Y., Mehta, M., Nghiemphu, P., Cloughesy, T., Taylor, L., Graber, J., Kilburn, L., Dixit, K., … Wen, P. (2022). SYST-14 CLINICAL EFFICACY OF ONC201 IN RECURRENT H3 K27M-MUTANT DIFFUSE MIDLINE GLIOMA (DMG) PATIENTS. Neuro-Oncology Advances, 4(Supplement_1), i24–i24. https://doi.org/10.1093/noajnl/vdac078.093
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Harimoto, T., Hahn, J., Chen, Y.-Y., Im, J., Zhang, J., Hou, N., Li, F., Coker, C., Gray, K., Harr, N., Chowdhury, S., Pu, K., Nimura, C., Arpaia, N., Leong, K. W., & Danino, T. (2022). A programmable encapsulation system improves delivery of therapeutic bacteria in mice. Nature Biotechnology, 40(8), 1259–1269. https://doi.org/10.1038/s41587-022-01244-y
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Yu, X., Gao, S., Wu, D., Li, Z., Mi, Y., Yang, T., Sun, F., Wang, L., Liu, R., He, S., Ge, Q., Lv, Y., Xu, A. (Yuanguang), & Zeng, H. (2022). Bone Tumor Suppression in Rabbits by Hyperthermia below the Clinical Safety Limit Using Aligned Magnetic Bone Cement (Small 3/2022). Small, 18(3). Portico. https://doi.org/10.1002/smll.202270012
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