Synthetic Lethal Mutations

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Nguyen, T. T. T., Torrini, C., Shang, E., Shu, C., Mun, J.-Y., Gao, Q., Humala, N., Akman, H. O., Zhang, G., Westhoff, M.-A., Karpel-Massler, G., Bruce, J. N., Canoll, P., & Siegelin, M. D. (2024). OGDH and Bcl-xL loss causes synthetic lethality in glioblastoma. JCI Insight. https://doi.org/10.1172/jci.insight.172565
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Li, P., Zhen, Y., Kim, C., Liu, Z., Hao, J., Deng, H., Deng, H., Zhou, M., Wang, X.-D., Qin, T., & Yu, Y. (2023). Nimbolide targets RNF114 to induce the trapping of PARP1 and synthetic lethality in BRCA -mutated cancer. Science Advances, 9(43). https://doi.org/10.1126/sciadv.adg7752
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