Mixed alkyl/aryl phosphonates identify metabolic serine hydrolases as antimalarial targets

Bennett, J. M., Narwal, S. K., Kabeche, S., Abegg, D., Thathy, V., Hackett, F., Yeo, T., Li, V. L., Muir, R., Faucher, F., Lovell, S., Blackman, M. J., Adibekian, A., Yeh, E., Fidock, D. A., & Bogyo, M. (2024). Mixed alkyl/aryl phosphonates identify metabolic serine hydrolases as antimalarial targets. Cell Chemical Biology, 31(9), 1714-1728.e10. https://doi.org/10.1016/j.chembiol.2024.07.006
Authors:
John M Bennett
Sunil K Narwal
Stephanie Kabeche
Daniel Abegg
Vandana Thathy
Fiona Hackett
Tomas Yeo
Veronica L Li
Ryan Muir
Franco Faucher
Scott Lovell
Michael J Blackman
Alexander Adibekian
Ellen Yeh
David A Fidock
Matthew Bogyo
Affiliated Authors:
Sunil K Narwal
Vandana Thathy
Tomas Yeo
David A Fidock
Columbia Affiliation:
Subjects:
Antimalarials (MeSH)
Plasmodium falciparum (MeSH)
Organophosphonates (MeSH)
Author Keywords:
activity-based probes
alky/aryl phosphonates
covalent probes
drug resistance
lipid metabolism
plasmodium falciparum
serine hydrolases
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Publication Type:
Article
Unique ID:
10.1016/j.chembiol.2024.07.006
PMID:
39137783
DOI:
10.1016/j.chembiol.2024.07.006
Journal:
Cell Chemical Biology
Publication Date:
Data Source:
PubMed
Source Link:
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Record Created: