Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria

Lawong, A., Gahalawat, S., Ray, S., Ho, N., Han, Y., Ward, K. E., Deng, X., Chen, Z., Kumar, A., Xing, C., Hosangadi, V., Fairhurst, K. J., Tashiro, K., Liszczak, G., Shackleford, D. M., Katneni, K., Chen, G., Saunders, J., Crighton, E., … Phillips, M. A. (2024). Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria. Cell Chemical Biology, 31(8), 1503-1517.e19. https://doi.org/10.1016/j.chembiol.2024.07.001
Authors:
Aloysus Lawong
Suraksha Gahalawat
Sneha Ray
Nhi Ho
Yan Han
Kurt E Ward
Xiaoyi Deng
Zhe Chen
Ashwani Kumar
Chao Xing
Varun Hosangadi
Kate J Fairhurst
Kyuto Tashiro
Glen Liszczak
David M Shackleford
Kasiram Katneni
Gong Chen
Jessica Saunders
Elly Crighton
Arturo Casas
Joshua J Robinson
Leah S Imlay
Xiaoyu Zhang
Andrew Lemoff
Zhiyu Zhao
Iñigo Angulo-Barturen
María Belén Jiménez-Díaz
Sergio Wittlin
Simon F Campbell
David A Fidock
Benoît Laleu
Susan A Charman
Joseph M Ready
Margaret A Phillips
Affiliated Authors:
Kurt E Ward
Varun Hosangadi
Kate J Fairhurst
David A Fidock
Columbia Affiliation:
Subjects:
Malaria (OpenAlex Topic)
Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (OpenAlex Topic)
Ubiquitin-Proteasome Proteolytic Pathway (OpenAlex Topic)
Piperidines (MeSH)
Plasmodium falciparum (MeSH)
Antimalarials (MeSH)
Proteasome Inhibitors (MeSH)
Author Keywords:
drug discovery
drug resistance
malaria
plasmodium
proteasome
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Publication Type:
Article
Unique ID:
10.1016/j.chembiol.2024.07.001
PMID:
39084225
DOI:
10.1016/j.chembiol.2024.07.001
Journal:
Cell Chemical Biology
Publication Date:
Data Source:
PubMed
Source Link:
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