Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures

Lish, A. M., Ashour, N., Pearse, R. V., Galle, P. C., Orme, G. A., Heuer, S. E., Benoit, C. R., Alexander, K. D., Grogan, E. F. L., Terzioglu, G., Scarpa, A., Stern, A. M., Seyfried, N., Menon, V., & Young-Pearse, T. L. (2025). Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures. Cell Reports, 44(6), 115777. https://doi.org/10.1016/j.celrep.2025.115777
Authors:
Alexandra M Lish
Nancy Ashour
Richard V Pearse
Paige C Galle
Gwendolyn A Orme
Sarah E Heuer
Courtney R Benoit
Kellianne D Alexander
Elyssa F L Grogan
Gizem Terzioglu
Allegra Scarpa
Andrew M Stern
Nicholas Seyfried
Vilas Menon
Tracy L Young-Pearse
Affiliated Authors:
Vilas Menon
Columbia Affiliation:
Subjects:
Induced Pluripotent Stem Cells (MeSH)
Microglia (MeSH)
Astrocytes (MeSH)
Neurons (MeSH)
Alzheimer Disease (MeSH)
Author Keywords:
alzheimer's disease
apoe
astrocytes
cp: neuroscience
cp: stem cell research
disease-associated microglia
fad
ipscs
microglial states
trem2
triculture
alzheimer’s disease
elink
Publication Type:
Article
Unique ID:
10.1016/j.celrep.2025.115777
PMID:
40471789
DOI:
10.1016/j.celrep.2025.115777
Journal:
Cell Reports
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
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Record Created: