Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic patch

Gretarsson, K. H., Abini-Agbomson, S., Gloor, S. L., Weinberg, D. N., McCuiston, J. L., Kumary, V. U. S., Hickman, A. R., Sahu, V., Lee, R., Xu, X., Lipieta, N., Flashner, S., Adeleke, O. A., Popova, I. K., Taylor, H. F., Noll, K., Windham, C. L., Maryanski, D. N., Venters, B. J., … Lu, C. (2024). Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic patch. Science Advances, 10(35). https://doi.org/10.1126/sciadv.adp0975
Authors:
Kristjan H. Gretarsson
Stephen Abini-Agbomson
Susan L. Gloor
Daniel N. Weinberg
Jamie L. McCuiston
Udayakumar S. Vishnu
Allison R. Hickman
Varun Sahu
Rachel Lee
Xinjing Xu
Natalie Lipieta
Samuel Flashner
Oluwatobi A. Adeleke
Irina K. Popova
Henry L. Taylor
Kelsey E. Noll
Carolina Lin Windham
Danielle Maryanski
Bryan J. Venters
Hiroshi Nakagawa
Michael‐Christopher Keogh
Karim‐Jean Armache
Chao Lü
Affiliated Authors:
Kristjan H. Gretarsson
Varun Sahu
Xinjing Xu
Natalie Lipieta
Samuel Flashner
Hiroshi Nakagawa
Chao Lü
Columbia Affiliation:
Subjects:
DNA Methylation (MeSH)
DNA Methyltransferase 3A (MeSH)
Nucleosomes (MeSH)
Histones (MeSH)
DNA (Cytosine-5-)-Methyltransferases (MeSH)
Ubiquitination (MeSH)
CpG Islands (MeSH)
Protein Binding (MeSH)
Neoplasms (MeSH)
Epigenetic Modifications and Their Functional Implications (OpenAlex Topic)
RNA Methylation and Modification in Gene Expression (OpenAlex Topic)
Regulation of Chromatin Structure and Function (OpenAlex Topic)
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Publication Type:
Article
Unique ID:
10.1126/sciadv.adp0975
PMID:
39196936
DOI:
10.1126/sciadv.adp0975
Journal:
Science Advances
Publication Date:
Data Source:
OpenAlex
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