PD-1 blockade increases the self-renewal of stem-like CD8 T cells to compensate for their accelerated differentiation into effectors

Gill, A. L., Wang, P. H., Lee, J., Hudson, W. H., Ando, S., Araki, K., Hu, Y., Wieland, A., Im, S., Gavora, A., Medina, C. B., Freeman, G. J., Hashimoto, M., Reiner, S. L., & Ahmed, R. (2023). PD-1 blockade increases the self-renewal of stem-like CD8 T cells to compensate for their accelerated differentiation into effectors. Science Immunology, 8(86). https://doi.org/10.1126/sciimmunol.adg0539

Authors:

Amanda L Gill

Peter H Wang

Judong Lee

William H Hudson

Satomi Ando

Koichi Araki

Yinghong Hu

Andreas Wieland

Sejin Im

Autumn Gavora

Christopher B Medina