R01MH106629

NIH – National Institute of Mental Health

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Regulation by Presynaptic NMDA Receptors of Non-Linear Postsynaptic Summation of the Cortical Input to CA1 Pyramidal Neurons

Buss, E. W., Jiang, Y.-Q., Santoro, B., Brann, D. H., Nicholson, D. A., Siegelbaum, S. A., & Sun, Q. (2024). Regulation by Presynaptic NMDA Receptors of Non-Linear Postsynaptic Summation of the Cortical Input to CA1 Pyramidal Neurons. Neuroscience. https://doi.org/10.1016/j.neuroscience.2024.06.005
Authors:
Eric W Buss
Yu-Qiu Jiang
Bina Santoro
David H Brann
Daniel A Nicholson
Steven A Siegelbaum
Qian Sun
Affiliated Authors:
Eric W Buss
Bina Santoro
David H Brann
Steven A Siegelbaum
Qian Sun
Columbia Affiliation:
Author Keywords:
ca1
ca2
hippocampus
nmda receptor
postsynaptic
presynaptic
biocytin
dizocilpine
isoflurane
receptors, n-methyl-d-aspartate
graphpad prism 9
imagej fiji
leica em cpc
leica lsm 700
leicalsm700
n methyl dextro aspartic acid receptor
animal experiment
animal model
animal tissue
article
brain cortex
current clamp technique
differential expression analysis
electrophysiological procedures
entorhinal cortex
excitatory postsynaptic potential
female
fluorescence intensity
gene deletion
hippocampal ca1 region
hippocampal ca2 region
immunogold electron microscopy
immunohistochemistry
long term depression
male
membrane steady potential
mouse
nerve cell plasticity
nonhuman
postsynaptic density
postsynaptic potential summation
purkinje cell
pyramidal nerve cell
stereotaxic surgery
stratum lacunosum moleculare
synapse vesicle
synaptic potential
synaptic transmission
temporal summation
voltage clamp technique
whole cell patch clamp
animal
c57bl mouse
cytology
drug effect
genetics
knockout mouse
metabolism
nerve ending
perforant nerve tract
physiology
ultrastructure
animals
ca1 region, hippocampal
excitatory postsynaptic potentials
mice
mice, inbred c57bl
mice, knockout
perforant pathway
presynaptic terminals
pyramidal cells
Grants:
R01MH130367 (NIH – National Institute of Mental Health)
R01MH129294 (NIH – National Institute of Mental Health)
R01MH106629 (NIH – National Institute of Mental Health)
R01MH104602 (NIH – National Institute of Mental Health)
K01MH117444 (NIH – National Institute of Mental Health)
Publication Type:
Article
Unique ID:
10.1016/j.neuroscience.2024.06.005
PMID:
38878815
DOI:
10.1016/j.neuroscience.2024.06.005
Journal:
Neuroscience
Publication Date:
Data Source:
PubMed
Source Link:
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Social odor discrimination and its enhancement by associative learning in the hippocampal CA2 region

Hassan, S. I., Bigler, S., & Siegelbaum, S. A. (2023). Social odor discrimination and its enhancement by associative learning in the hippocampal CA2 region. Neuron, 111(14), 2232-2246.e5. https://doi.org/10.1016/j.neuron.2023.04.026
Authors:
Sami I Hassan
Shivani Bigler
Steven A Siegelbaum
Affiliated Authors:
Sami I Hassan
Shivani Bigler
Steven A Siegelbaum
Columbia Affiliation:
Subjects:
Odorants (MeSH)
CA2 Region, Hippocampal (MeSH)
Author Keywords:
associative learning
ca2
calcium imaging
hippocampus
social discrimination
social odors
social sensory coding
Grants:
R01MH104602 (NIH – National Institute of Mental Health)
R01MH106629 (NIH – National Institute of Mental Health)
F31MH126622 (NIH – National Institute of Mental Health)
Publication Type:
Article
Unique ID:
10.1016/j.neuron.2023.04.026
PMID:
37192623
DOI:
10.1016/j.neuron.2023.04.026
Journal:
Neuron
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View Scopus Record

Record Created:

A direct lateral entorhinal cortex to hippocampal CA2 circuit conveys social information required for social memory

Lopez-Rojas, J., de Solis, C. A., Leroy, F., Kandel, E. R., & Siegelbaum, S. A. (2022). A direct lateral entorhinal cortex to hippocampal CA2 circuit conveys social information required for social memory. Neuron, 110(9), 1559-1572.e4. https://doi.org/10.1016/j.neuron.2022.01.028
Authors:
Jeffrey Lopez-Rojas
Christopher A. de Solis
Felix Leroy
Eric R. Kandel
Steven A. Siegelbaum
Affiliated Authors:
Jeffrey Lopez-Rojas
Christopher A. de Solis
Felix Leroy
Eric R. Kandel
Steven A. Siegelbaum
Columbia Affiliation:
Subjects:
Entorhinal Cortex (MeSH)
Hippocampus (MeSH)
Author Keywords:
ca2
entorhinal cortex
hippocampus
lateral entorhinal cortex
social memory
Grants:
R01MH106629 (NIH – National Institute of Mental Health)
R01MH104602 (NIH – National Institute of Mental Health)
Publication Type:
Article
Unique ID:
10.1016/j.neuron.2022.01.028
PMID:
35180391
DOI:
10.1016/j.neuron.2022.01.028
Journal:
Neuron
Publication Date:
Data Source:
Scopus
Source Link:
View Scopus Record
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Record Created:

Frequency-dependent synaptic dynamics differentially tune CA1 and CA2 pyramidal neuron responses to cortical input

Sun, Q., Buss, E. W., Jiang, Y.-Q., Santoro, B., Brann, D. H., Nicholson, D. A., & Siegelbaum, S. A. (2021). Frequency-Dependent Synaptic Dynamics Differentially Tune CA1 and CA2 Pyramidal Neuron Responses to Cortical Input. The Journal of Neuroscience, 41(39), 8103–8110. https://doi.org/10.1523/jneurosci.0451-20.2021
Authors:
Qian Sun
Eric W. Buss
Yu-Qiu Jiang
Bina Santoro
David H. Brann
Daniel A. Nicholson
Steven A. Siegelbaum
Affiliated Authors:
Qian Sun
Eric W. Buss
Bina Santoro
David H. Brann
Steven A. Siegelbaum
Columbia Affiliation:
Subjects:
CA1 Region, Hippocampal (MeSH)
CA2 Region, Hippocampal (MeSH)
Cerebral Cortex (MeSH)
Excitatory Postsynaptic Potentials (MeSH)
Pyramidal Cells (MeSH)
Synapses (MeSH)
Author Keywords:
ca1
ca2
nmdar
hippocampus
perforant path
synaptic
Grants:
K01MH117444 (NIH – National Institute of Mental Health)
R01MH106629 (NIH – National Institute of Mental Health)
R01MH104602 (NIH – National Institute of Mental Health)
Publication Type:
Article
Unique ID:
10.1523/JNEUROSCI.0451-20.2021
PMID:
34385360
DOI:
10.1523/JNEUROSCI.0451-20.2021
Journal:
Journal of Neuroscience
Publication Date:
Data Source:
Scopus
Source Link:
View Scopus Record
View Web of Science Record
View PubMed Record

Record Created:

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